Avalide

Generic name: Hydrochlorothiazide And Irbesartan
Drug class: Angiotensin II inhibitors with thiazides

Usage of Avalide

Avalide tablets contain a combination of hydrochlorothiazide and irbesartan. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Irbesartan is an angiotensin II receptor antagonist. Irbesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Avalide is used to treat high blood pressure (hypertension).

Avalide may also be used for purposes not listed in this medication guide.

Avalide side effects

Get emergency medical help if you have signs of an allergic reaction to Avalide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Avalide can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

eye pain, vision problems;

a light-headed feeling, like you might pass out;

little or no urinating;

jaundice (yellowing of the skin or eyes);

easy bruising, unusual bleeding; or

signs of an electrolyte imbalance - increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling.

Common Avalide side effects may include:

dizziness;

muscle or joint pain; or

feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Avalide

You should not use Avalide if you are allergic to irbesartan or hydrochlorothiazide, or:

if you are unable to urinate; or

if you are allergic to sulfa drugs.

If you have diabetes, do not use Avalide together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

You may also need to avoid taking Avalide with aliskiren if you have kidney disease.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver disease;

congestive heart failure;

glaucoma;

low or high levels of potassium in your blood;

asthma or allergies;

high cholesterol or triglyceride levels;

gout;

lupus;

diabetes; or

an allergy to penicillin.

Do not use if Avalide you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Irbesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using this medicine.

Relate drugs

How to use Avalide

Usual Adult Dose for Hypertension:

Initial therapy: Hydrochlorothiazide 12.5 mg-Irbesartan 150 mg orally once a day; may increase after 1 to 2 weeks. Add-on/Replacement therapy: Hydrochlorothiazide 12.5 to 25 mg-Irbesartan 150 to 300 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Irbesartan 300 mg orally once a day Comments: -The recommended doses in order of increasing mean effect are (hydrochlorothiazide-irbesartan): 12.5 mg-150 mg, 12.5 mg-300 mg, 25 mg-300 mg; the largest incremental effect will likely be from monotherapy to 12.5 mg-150 mg. -Maximum antihypertensive effect is attained within 2 to 4 weeks after a change in dose.

Warnings

Do not use Avalide if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs.

If you have diabetes, do not use Avalide together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

In rare cases, Avalide can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.

What other drugs will affect Avalide

If you also take cholestyramine or colestipol, take your Avalide dose 4 hours before or 4 hours after you take the other medicine.

Tell your doctor about all your current medicines and any you start or stop using, especially:

carbamazepine;

insulin or oral diabetes medicine;

lithium; or

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with hydrochlorothiazide and irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed in this medication guide.

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