Avandaryl
Generic name: Glimepiride And Rosiglitazone
Drug class:
Antidiabetic combinations
Usage of Avandaryl
Avandaryl contains a combination of glimepiride and rosiglitazone, two oral diabetes medicines that help control blood sugar levels.
Avandaryl is for people with type 2 diabetes. This medication is not for treating type 1 diabetes.
Avandaryl is not recommended for use with insulin. Taking Avandaryl while you are using insulin may increase your risk of serious heart problems.
Avandaryl side effects
Get emergency medical help if you have signs of an allergic reaction to Avandaryl: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common Avandaryl side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Avandaryl
You should not use Avandaryl if you are allergic to glimepiride or rosiglitazone, or:
To make sure Avandaryl is safe for you, tell your doctor if you have:
Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking Avandaryl. Talk with your doctor if you are concerned about this possibility.
Do not use Avandaryl if you are pregnant. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant.
Some women using Avandaryl have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.
It is not known whether glimepiride and rosiglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Avandaryl.
Relate drugs
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- Avandaryl
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- Duetact
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- Empagliflozin and metformin
- Empagliflozin, linagliptin, and metformin
- Ertugliflozin and metformin
- Ertugliflozin and sitagliptin
- Glimepiride and pioglitazone
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- Glucovance
- Glyburide and metformin
- Glyxambi
- Insulin degludec and liraglutide
- Insulin glargine and lixisenatide
- Invokamet
- Invokamet XR
- Janumet
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- Jentadueto
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- Kazano
- Kombiglyze XR
- Linagliptin and metformin
- Metaglip
- Metformin and pioglitazone
- Metformin and saxagliptin
- Metformin and sitagliptin
- Oseni
- Pioglitazone and glimepiride
- Pioglitazone and metformin
- PrandiMet
- Qtern
- Repaglinide and metformin
- Rosiglitazone and glimepiride
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- Saxagliptin and dapagliflozin
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- Segluromet
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- Soliqua
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- Steglujan
- Synjardy
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- Trijardy XR
- Xigduo XR
- Xultophy
How to use Avandaryl
Usual Adult Dose of Avandaryl for Diabetes Type 2:
Individualize dose based on safety, efficacy, and prior therapy; asses the risk versus benefit of initiating with combination therapy versus monotherapy Initial dose: rosiglitazone 4 mg/glimepiride 1 mg orally once a day -Patients receiving a sulfonylurea or rosiglitazone: May consider a starting dose of rosiglitazone 4 mg/glimepiride 2 mg orally once a day -Patients receiving rosiglitazone and glimepiride as individual components: Initial dose is the combination product containing the same dose of each component Dose Titration: Individualize based on glycemic response and safety concerns for each component. -Patients switching from rosiglitazone: Titrate glimepiride after 1 to 2 weeks in increments of no more than 2 mg; following increase, rosiglitazone may be titrated after 1 to 2 weeks -Patients switching from sulfonylurea: Titrate rosiglitazone after 8 to 12 weeks; allow 2 to 3 months to see full effect of increase before further titration Maximum dose: rosiglitazone 8 mg/glimepiride 4 mg Comments: Take with first meal of the day. -Monitor closely for fluid related adverse events, particularly with rosiglitazone initiation and titration. -If hypoglycemia occurs, dose reduction of the glimepiride component may be necessary. Use: To improve glycemic control in adult patients with type 2 diabetes mellitus as an adjunct to diet and exercise.
Warnings
You should not use Avandaryl if you have severe or uncontrolled heart failure, or if you are allergic to sulfa drugs. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Avandaryl can cause or worsen congestive heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.
What other drugs will affect Avandaryl
Tell your doctor if you use insulin. Taking Avandaryl while you are using insulin may increase your risk of serious heart problems.
Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Many other medicines can increase or decrease the effects of Avandaryl on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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