Avatrombopag

Generic name: Avatrombopag
Dosage form: oral tablet (20 mg)
Drug class: Platelet-stimulating agents

Usage of Avatrombopag

Avatrombopag is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

Avatrombopag is also used to treat chronic immune thrombocytopenia when other treatments have failed.

Avatrombopag is not a cure for thrombocytopenia and it will not make your platelet counts normal.

Avatrombopag may also be used for purposes not listed in this medication guide.

Avatrombopag side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot while using avatrombopag. Call your doctor or get emergency medical help if you have:

chest pain, shortness of breath;

fast heartbeats;

pain, swelling, or redness in one or both legs;

stomach pain or tenderness;

sudden fever or chills, yellowing of your skin or eyes; or

bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects of avatrombopag may include:

fever;

easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin;

feeling tired;

headache, joint pain;

cold symptoms such as runny or stuffy nose, sneezing, sore throat;

nausea, stomach pain; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Avatrombopag

You should not use avatrombopag if you are allergic to it.

Tell your doctor if you have ever had:

a blood clot; or

a bleeding or blood clotting disorder other than thrombocytopenia.

Your doctor will measure your platelet levels with a blood test before you start taking avatrombopag.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using avatrombopag, and for at least 2 weeks after your last dose.

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How to use Avatrombopag

Usual Adult Dose for Thrombocytopenia:

Chronic Liver Disease:Platelet count less than 40 x 10(9)/L: 60 mg orally once a day starting 10 to 13 days prior to the scheduled procedurePlatelet count 40 to less than 50 x 10(9)/L: 40 mg orally once a day starting 10 to 13 days prior to the scheduled procedureDuration of therapy: 5 daysComments:-Patients should undergo their procedure 5 to 8 days after the last dose of this drug.-Do not use this drug to normalize platelet counts.Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.Chronic Immune Thrombocytopenia:Initial dose: 20 mg orally once a day with foodMaximum dose: 40 mg/dayComments:-Use the lowest dose needed to achieve and maintain a platelet count greater than or equal to 50 x 10(9)/L as necessary to reduce the risk for bleeding.-Do not use this drug to normalize platelet counts.Use: Treatment of thrombocytopenia in patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Avatrombopag

Other drugs may affect avatrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Doptelet (avatrombopag) is used to increase the level of platelets in the blood, in patients that have low platelets levels (thrombocytopenia) with chronic liver disease (CLD) and are scheduled to undergo a procedure or chronic immune thrombocytopenia (ITP) and have not had a good response from another treatment. Continue reading

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