Bepotastine

Brand names: Bepreve
Drug class: Antineoplastic Agents

Usage of Bepotastine

Allergic Conjunctivitis

Symptomatic treatment of ocular itching associated with allergic conjunctivitis.

Relate drugs

How to use Bepotastine

Administration

Ophthalmic Administration

Apply topically to the eye as an ophthalmic solution.

Remove soft contact lenses prior to administration of each dose (since benzalkonium chloride may be absorbed by the lenses); may reinsert lenses after 10 minutes following administration if eyes are not red.

Avoid contamination of the solution container.

Dosage

Available as Bepotastine besilate; dosage expressed in terms of the salt.

Pediatric Patients

Allergic Conjunctivitis Ophthalmic

Children ≥2 years of age: 1 drop of a 1.5% solution in the affected eye(s) twice daily.

Adults

Allergic Conjunctivitis Ophthalmic

1 drop of a 1.5% solution in the affected eye(s) twice daily.

Warnings

Contraindications

  • Manufacturer states none known.

    • Warnings/Precautions

    Administration

    For topical ophthalmic use only.

    Proper Handling to Avoid Contamination

    To avoid contamination of the dropper tip and solution, do not to touch the eyelids or surrounding areas with the dropper tip.

    Close container tightly when not in use.

    Contact Lenses

    Remove contact lenses prior to administration of each dose, since benzalkonium chloride preservative may be absorbed by soft contact lenses; lenses may be reinserted after 10 minutes following administration if eyes are not red; patient should not wear contact lenses if eyes are red. Not indicated for contact lens-related ocular irritation.

    Specific Populations

    Pregnancy

    Category C.

    Lactation

    Distributed into milk in rats following oral administration.

    Not known whether bepotastine besilate distributes into human milk following topical application to the eye. Use caution.

    Pediatric Use

    Safety and efficacy not established in pediatric patients <2 years of age. Efficacy in pediatric patients <10 years of age was extrapolated from clinical trials conducted in pediatric patients >10 years of age and adults.

    Geriatric Use

    No overall differences in efficacy or safety observed between geriatric and younger patients.

    Common Adverse Effects

    Mild taste following instillation, ocular irritation, headache, nasopharyngitis.

    What other drugs will affect Bepotastine

    Minimally metabolized by CYP isoenzymes.

    Drugs Metabolized by Hepatic Microsomal Enzymes

    Low potential for drug interactions via inhibition of CYP isoenzymes 3A4, 2C9, and 2C19.

    Effect on metabolism of substrates of CYP isoenzymes 1A2, 2C8, and 2D6 not established.

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