Beta Glucans

Brand names: Beta-1,3-glucan, Beta-1,6-glucan, Beta-glucans

Usage of Beta Glucans

Reviews provide an overview of the beta-glucans(Chen 2007, Chen 2008, Mantovani 2008, Novak 2008, Novak 2009, Volman 2008) as well as meta-analyses of studies using cereal beta-glucan in the modification of lipids and lentinan in gastric cancer.(Haggård 2013, Kelly 2007, Oba 2009, Talati 2009) Clinical trials and meta-analyses of randomized controlled trials have assessed the effects of beta-glucan extract on glycemic control and insulin sensitivity,(He 2016) as well as beta-glucan's antimicrobial, wound healing, and immunomodulatory activities.(Garcia 2014, Koray 2009, Yenidogan 2014) Beta-glucan supplementation as an adjuvant to chemotherapy in patients with a variety of advanced malignancies has been well tolerated and may have beneficial effects; further studies are needed.(Weitberg 2008)

Note: When the source of the beta-glucan extract used was not clearly defined for a study, data were included in this monograph. For more detailed, source-specific study information, see the individual monographs for the beta-glucan sources (Brewer's Yeast, Lentinan [shiitake], Maitake [grifola], Seaweed, Oats, and Barley).

Antimicrobial activity

Clinical data

In a 27-year-old man, beta-glucan 5 mg/week as an adjuvant to itraconazole 200 mg/day was effective in treating paracoccidioidomycosis cutaneous lesions initially unresponsive to itraconazole monotherapy.(Garcia 2014)

GI effects

The American College of Gastroenterology (ACG) clinical guideline for the management of irritable bowel syndrome (IBS) (2021) suggests that soluble, but not insoluble, fiber be used to treat global IBS symptoms (Strong; moderate).(Lacy 2021)

Immunomodulation/Wound healing

Clinical data

A randomized, placebo-controlled trial demonstrated improved ulcer severity scores and lymphocyte proliferation in 31 patients with recurrent aphthous stomatitis (RAS) given beta-glucan 10 mg twice daily for 20 days. Lymphocyte proliferation, which was lower at baseline in the 31 RAS patients compared with 42 healthy controls, significantly increased in RAS patients receiving beta-glucan treatment compared with baseline (P=0) and compared with RAS patients who received placebo (P=0.03). Likewise, ulcer severity scores decreased in the beta-glucan group compared with baseline (P=0).(Koray 2009) A double-blind, randomized, placebo-controlled trial conducted in 130 females undergoing modified radical mastectomy investigated the effect of beta-glucan capsules (10 mg twice daily orally for 10 days postsurgery) on postoperative seroma drain fluid. Compared with placebo, beta-glucan improved drainage volume (P=0.002) and mean time to drain removal (mean, 7.16 days vs 8.59 days with placebo; P=0.001) as well as interleukin-6 and tumor necrosis factor-alpha levels.(Yenidogan 2014)

Topical use of beta-glucan gel was investigated for its effects on wound healing in a trial of 39 patients, with 26 patients completing the minimum 4-week study period required for evaluation. During the 12-week evaluation period, 7 wounds were fully healed, 8 had a more than 50% reduction in size, 5 demonstrated moderate healing progression, and 6 did not respond to treatment.(King 2017)

Beta Glucans side effects

A single-blind, randomized, controlled-exposure, crossover study conducted in 50 healthy adults identified an acute negative effect on blood pressure (ie, increases) with inhalation of beta-1,3-D-glucan particulate matter. In contrast to endotoxin, no effect on pulse pressure was observed with beta-glucan particulate matter.Zhong 2015

See individual monographs for adverse events related to the specific beta-glucan sources.

Before taking Beta Glucans

Information regarding safety and efficacy in pregnancy and lactation is lacking. See individual monographs for information related to the specific beta-glucan sources.

How to use Beta Glucans

See individual monographs for dosing recommendations for the specific beta-glucan sources.

Warnings

See individual monographs for toxicology information related to the specific beta-glucan sources.

What other drugs will affect Beta Glucans

See individual monographs for interactions related to the specific beta-glucan sources.

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