Betaxolol (EENT)
Brand names: Betoptic S
Drug class:
Antineoplastic Agents
Usage of Betaxolol (EENT)
Ocular Hypertension and Glaucoma
Reduction of elevated IOP in patients with chronic open-angle glaucoma or ocular hypertension.
As effective as timolol in reducing IOP in patients with chronic open-angle glaucoma but, unlike timolol, is associated with minimal adverse pulmonary or cardiovascular effects.
Has been used safely in selected patients with reactive airway disease (e.g., asthma, chronic bronchitis, COPD). (See Respiratory Disease under Cautions.)
When selecting an initial ocular hypotensive agent, consider extent of the required IOP reduction, coexisting medical conditions, and drug characteristics (e.g., dosing frequency, adverse effects, cost). With single-agent regimens, the reduction in IOP is approximately 25–33% with topical prostaglandin analogs; 20–25% with topical β-adrenergic blocking agents, α-adrenergic agonists, or miotic (parasympathomimetic) agents; 20–30% with oral carbonic anhydrase inhibitors; 18% with topical rho kinase inhibitors; and 15–20% with topical carbonic anhydrase inhibitors.
A prostaglandin analog frequently is considered for initial therapy in the absence of other considerations (e.g., contraindications, cost considerations, intolerance, adverse effects, patient refusal) because of relatively greater activity, once-daily administration, and low frequency of systemic adverse effects; however, ocular adverse effects can occur.
Goal is to maintain an IOP at which visual field loss is unlikely to substantially reduce quality of life during the patient's lifetime.
Reduction of pretreatment IOP by ≥25% shown to slow progression of primary open-angle glaucoma. Set an initial target IOP (based on extent of optic nerve damage and/or visual field loss, baseline IOP at which damage occurred, rate of progression, life expectancy, and other considerations) and reduce IOP toward this goal. Adjust target IOP up or down as needed over course of disease.
Combination therapy with drugs from different therapeutic classes often required to control IOP.
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How to use Betaxolol (EENT)
General
Administration
Ophthalmic Administration
Apply topically to the eye as an ophthalmic solution or suspension.
Avoid contamination of the solution or suspension container. (See Bacterial Keratitis under Cautions.)
Shake suspension well prior to use.
Administer any concomitant topical ophthalmic drugs ≥10 minutes before administering the suspension.
Remove contact lenses before administering each Betaxolol dose; may reinsert lenses 15 minutes after the dose. (See Contact Lenses under Cautions.)
Dosage
Available as betaxolol hydrochloride; dosage expressed in terms of betaxolol.
Betaxolol 0.25% ophthalmic suspension is therapeutically equivalent (in terms of magnitude and duration of hypotensive effect) to the 0.5% solution.
Pediatric Patients
Ocular Hypertension and Glaucoma OphthalmicBetaxolol 0.25% ophthalmic suspension: 1 drop in the affected eye(s) twice daily.
Adults
Ocular Hypertension and Glaucoma OphthalmicBetaxolol 0.5% ophthalmic solution: 1 or 2 drops in the affected eye(s) twice daily.
Betaxolol 0.25% ophthalmic suspension: 1 drop in the affected eye(s) twice daily.
If target IOP not achieved, may initiate additional or alternative ocular hypotensive agents. (See Ocular Hypertension and Glaucoma under Uses.)
Warnings
Contraindications
Warnings/Precautions
Sensitivity Reactions
History of Atopy or Anaphylactic ReactionsPatients with a history of atopy or severe anaphylactic reaction to a variety of allergens may be more reactive to repeated accidental, diagnostic, or therapeutic challenges with such allergens while taking β-adrenergic blocking agents; such patients may be unresponsive to usual doses of epinephrine used to treat anaphylactic reactions.
Systemic Effects
May be absorbed systemically following topical application to the eye; consider the usual precautions associated with systemic use of β-adrenergic blocking agents when using topical betaxolol.
Cardiovascular Effects
Severe cardiac reactions, including death associated with cardiac failure, reported in patients receiving topical (ocular) β-adrenergic blocking agents.
Minor effects on BP and heart rate reported with topical betaxolol.
Contraindicated in patients with AV block greater than first degree, cardiogenic shock, or overt cardiac failure that is not adequately compensated (e.g., treated with cardiac glycosides and/or diuretics). Use with caution in patients with a history of cardiac failure or heart block. Discontinue therapy at the first sign or symptom of cardiac failure.
Diabetes Mellitus
β-Adrenergic blocking agents may mask signs and symptoms of acute hypoglycemia; administer with caution in patients subject to hypoglycemia and in diabetic patients (especially those with labile diabetes) who are receiving hypoglycemic agents.
Thyrotoxicosis
β-Adrenergic blocking agents may mask signs of hyperthyroidism (e.g., tachycardia).
Possible thyroid storm if β-adrenergic blocking agent is abruptly withdrawn; carefully monitor patients having or suspected of developing thyrotoxicosis.
Muscle Weakness
β-Adrenergic blocking agents reported to potentiate muscle weakness consistent with certain myasthenic manifestations (e.g., diplopia, ptosis, generalized weakness).
Major Surgery
Possible increased risks associated with general anesthesia (e.g., severe, protracted hypotension; difficulty restarting or maintaining heart beat) due to decreased ability of the heart to respond to reflex β-adrenergic stimuli.
Need for withdrawal of β-adrenergic blocking agents prior to major surgery is controversial; consider gradual withdrawal of β-adrenergic blocking agents prior to elective surgery.
If necessary during surgery, may reverse effects of β-adrenergic blocking agents by administering sufficient doses of adrenergic agonists.
Respiratory Disease
Severe respiratory reactions, including death resulting from bronchospasm, reported in patients with asthma receiving topical (ocular) β-adrenergic blocking agents.
Topical betaxolol has been used safely in selected patients with reactive airway disease; however, increased airway resistance and pulmonary distress (i.e., dyspnea, bronchospasm, thickened bronChial secretions, asthma, respiratory failure) also reported with the drug. Use caution in patients with evidence of reactive airway disease on pulmonary function testing or excessive restriction of pulmonary function.
Angle-closure Glaucoma
Betaxolol has little to no effect on pupil size. Do not use alone in patients with angle-closure glaucoma; use only in combination with a miotic in these patients.
Vascular Insufficiency
Caution advised in patients with vascular insufficiency due to the potential effects of β-adrenergic blocking agents on BP and pulse.
Consider alternative therapy if signs or symptoms of Raynaud phenomenon or reduced cerebral blood flow occur.
Bacterial Keratitis
Bacterial keratitis reported with use of multiple-dose containers of topical ophthalmic solutions. Containers were inadvertently contaminated by patients, most of whom had concurrent corneal disease or disruption of the ocular epithelial surface.
Improper handling of ophthalmic preparations can result in contamination of the preparations by common bacteria known to cause ocular infections. Serious damage to the eye and subsequent loss of vision may result from using contaminated ophthalmic preparations. (See Advice to Patients.)
Choroidal Detachment
Choroidal detachment after filtration procedures reported with the administration of aqueous suppressant therapy.
Contact Lenses
Betaxolol ophthalmic solution and suspension contain benzalkonium chloride, which may be absorbed by soft contact lenses. Remove contact lenses before administering each betaxolol dose; may reinsert lenses 15 minutes after the dose.
Specific Populations
PregnancyCategory C.
Use only if potential benefits justify possible risk to fetus.
LactationDistributed into milk. Caution advised if used in nursing women.
Pediatric UseBetaxolol 0.25% suspension: Safety and efficacy in pediatric patients established in a 3-month, active-controlled clinical trial; adverse effects comparable to those observed in adults.
Betaxolol 0.5% solution: Manufacturer states that safety and efficacy not established in pediatric patients.
Geriatric UseNo overall differences in safety and efficacy relative to younger adults.
Common Adverse Effects
Ocular stinging and discomfort on instillation. May be more common with solution than with suspension.
What other drugs will affect Betaxolol (EENT)
Specific Drugs
Drug
Interaction
Comments
Adrenergic psychotropic agents
Possible antagonism of psychotropic agent
Use concomitantly with caution
β-Adrenergic blocking agents, systemic
Possible additive effects on IOP and/or systemic β-adrenergic blockade
Antiarrhythmic agents (e.g., amiodarone)
Possible additive effects (e.g., hypotension, marked bradycardia)
Calcium-channel blocking agents
Possible additive effects (e.g., hypotension, marked bradycardia)
Cardiac glycosides
Possible additive effects (e.g., hypotension, marked bradycardia)
Catecholamine-depleting drugs (e.g., reserpine)
Possible additive effects (e.g., hypotension, marked bradycardia); may be manifested as vertigo, syncope, or postural hypotension
Observe closely
Epinephrine
Atopic individuals and those with a history of severe anaphylactic reactions may not respond to usual doses of epinephrine used in the treatment of anaphylactic reactions
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Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
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