Binimetinib
Generic name: Binimetinib
Brand names: Mektovi
Dosage form: oral tablet (15 mg)
Drug class:
Multikinase inhibitors
Usage of Binimetinib
Binimetinib is used in combination with another medicine called encorafenib (Braftovi) to treat melanoma (skin cancer) in people who have a "BRAF" gene mutation. These medicines are for use in treating melanoma that cannot be treated with surgery or has spread to other parts of the body.
Binimetinib may also be used for purposes not listed in this medication guide.
Binimetinib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects are more likely to occur if you take binimetinib and encorafenib together. Call your doctor at once if you have:
Common side effects of binimetinib may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Binimetinib
You should not use binimetinib if you are allergic to it.
Tell your doctor if you have ever had:
Do not use binimetinib if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using binimetinib and for at least 30 days after your last dose.
Tell your doctor if you think you may be pregnant. You may need to have a negative pregnancy test before starting this treatment.
You should not breastfeed while using this medicine, and for at least 3 days after your last dose.
Relate drugs
- Afatinib
- Alecensa
- Alectinib
- Alunbrig
- Avapritinib
- Ayvakit
- Cobimetinib
- Cotellic
- Crizotinib
- Balversa
- Binimetinib
- Braftovi
- Brigatinib
- Capmatinib
- Ceritinib
- Dabrafenib
- Deucravacitinib
- Encorafenib
- Entrectinib
- Erdafitinib
- Fedratinib
- Futibatinib
- Gavreto
- Gilotrif
- Gilteritinib
- Infigratinib
- Inrebic
- Jakafi
- Koselugo
- Larotrectinib
- Litfulo
- Lorbrena
- Lorlatinib
- Lytgobi
- Mekinist
- Mektovi
- Midostaurin
- Momelotinib
- Nintedanib
- Ofev
- Ojjaara
- Pacritinib
- Pemazyre
- Pemigatinib
- Pexidartinib
- Pralsetinib
- Qinlock
- Retevmo
- Ripretinib
- Ritlecitinib
- Rozlytrek
- Ruxolitinib
- Ruxolitinib (Oral)
- Rydapt
- Selpercatinib
- Selumetinib
- Sotyktu
- Tabrecta
- Tafinlar
- Tepmetko
- Tepotinib
- Trametinib
- Truseltiq
- Turalio
- Ukoniq
- Umbralisib
- Vemurafenib
- Vitrakvi
- Vonjo
- Xalkori
- Xospata
- Zelboraf
- Zykadia
How to use Binimetinib
Usual Adult Dose for Melanoma -- Metastatic:
45 mg orally every 12 hours in combination with encorafenib until disease progression or unacceptable toxicityComments:-Refer to the encorafenib prescribing information for encorafenib dosing information.-This drug may be taken with or without food.-Do not take a missed dose within 6 hours of the next dose.-Do not take an additional dose if vomiting occurs after administration but continue with the next scheduled dose.Use: In combination with encorafenib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test
Warnings
Binimetinib can cause birth defects. Do not use if you are pregnant. Avoid getting pregnant while using binimetinib and for at least 30 days after your last dose.
What other drugs will affect Binimetinib
Other drugs may affect binimetinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Popular FAQ
Mektovi is used in combination with another medicine called encorafenib (Braftovi) to treat advanced forms of melanoma (skin cancer) and non-small cell lung cancer with certain BRAF gene mutations. Continue reading
Mektovi is used in combination with another medicine called encorafenib (Braftovi) to treat advanced forms of melanoma (skin cancer) and non-small cell lung cancer with certain BRAF gene mutations. Continue reading
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