Blenrep

Generic name: Belantamab Mafodotin
Drug class: Miscellaneous antineoplastics

Usage of Blenrep

Blenrep is an antibody targeting B-cell maturation antigens (BCMA).

Blenrep is used to treat multiple myeloma in adults. This medicine is given after at least 4 other treatments did not work or have stopped working.

Blenrep was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Blenrep is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

Blenrep side effects

Get emergency medical help if you have signs of an allergic reaction to Blenrep: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection (infusion reaction). Tell your caregiver if you feel dizzy, tired, nauseated, light-headed, itchy, feverish, chilled, sweaty, short of breath, or have racing heartbeats, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

  • sudden vision loss;
  • easy bruising, unusual bleeding; or
  • signs of bleeding in the brain - weakness, dizziness, confusion, numbness or tingling on one side of the body, loss of movement in your face.
  • Tell your eye doctor if you have any eye problems, changes in your vision, dry eyes, or vision loss.

    Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

    Common Blenrep side effects may include:

  • vision changes;
  • eye changes found during an eye exam;
  • infusion reaction;
  • abnormal lab tests;
  • fever, tiredness; or
  • nausea.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Blenrep

    To make sure Blenrep is safe for you, tell your doctor if you have ever had::

  • problems with your eyes;
  • vision problems; or
  • bleeding problems.
  • You may need to have a negative pregnancy test before starting this treatment.

    Belantamab mafodotin can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, do not use Blenrep if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 6 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Blenrep.
  • This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because belantamab mafodotin can harm an unborn baby.

    Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

    Relate drugs

    How to use Blenrep

    Usual Adult Dose for Multiple Myeloma:

    2.5 mg/kg (of actual body weight) IV over 30 minutes once every 3 weeks until disease progression or unacceptable toxicity Use: For treatment of adult patients with relapsed or refractory multiple myeloma who have received at least 4 prior therapies including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent

    Warnings

    An eye doctor will need to examine your eyes before each dose of this medicine. Blenrep can cause changes to the surface of your eye that can lead to dry eyes, blurred vision, worsening vision, severe vision loss, and an ulcer on the surface of your eye. Tell your healthcare provider if you have any vision changes or eye problems during your treatment.

    Even if your vision seems fine, it is important that you get your eyes checked during treatment with Blenrep because some changes can happen without symptoms and may only be seen on an eye exam.

    You should use preservative-free lubricant eye drops at least 4 times per day during treatment with Blenrep as instructed by your healthcare provider. You should use caution when driving or operating machinery as this medicine may affect your vision.

    Avoid wearing contact lenses during treatment with Blenrep unless directed by your eye specialist.

    What other drugs will affect Blenrep

    Other drugs may interact with belantamab mafodotin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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