Bosutinib

Generic name: Bosutinib
Brand names: Bosulif
Dosage form: oral tablet (100 mg; 400 mg; 500 mg)
Drug class: BCR-ABL tyrosine kinase inhibitors

Usage of Bosutinib

Bosutinib is used in adults to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia (CML).

Bosutinib is usually given after other treatments have failed.

Bosutinib may also be used for purposes not listed in this medication guide.

Bosutinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching; dizziness; back pain, joint pain; difficult breathing; swelling of your face, lips, tongue, or throat.

Bosutinib may cause serious side effects. Stop using bosutinib and call your doctor at once if you have:

severe or ongoing nausea, vomiting, stomach pain, or diarrhea;

blood in your stools;

urinating more or less than usual;

feeling light-headed or short of breath;

heart problems--swelling, rapid weight gain, feeling short of breath;

low blood cell counts--fever, chills, tiredness, flu-like symptoms, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet;

liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

swelling or fluid build-up in the lungs--anxiety, sweating, pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of bosutinib may include:

headache, feeling tired;

nausea, vomiting, diarrhea, stomach pain;

fever, cough;

abnormal liver function tests;

swelling;

rash; or

low blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Bosutinib

You should not use bosutinib if you are allergic to it.

Tell your doctor if you have ever had:

heart disease;

liver disease; or

kidney disease.

You may need to have a negative pregnancy test before starting this treatment.

Bosutinib may harm an unborn baby. Use effective birth control while you are using bosutinib, and for at least 2 weeks after your last dose. Tell your doctor right away if you become pregnant.

You should not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Relate drugs

How to use Bosutinib

Usual Adult Dose for Chronic Myelogenous Leukemia:

Newly-diagnosed:400 mg orally once daily Duration of therapy: Until disease progression or patient intoleranceChronic/accelerated/blast phase:500 mg orally once daily Duration of therapy: Until disease progression or patient intoleranceComments: -Take this drug with food.-If a dose is missed beyond 12 hours, the patient should skip the dose and take the usual prescribed dose on the following day.Uses:-For newly-diagnosed chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML)-For chronic phase, accelerated phase (AP), or blast phase (BP) Ph+ CML with resistance or intolerance to prior therapy

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Bosutinib

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Some medicines can make bosutinib much less effective when taken at the same time. If you take an antacid or stomach acid reducer (Zantac, Prilosec, and others), take your bosutinib dose 2 hours before or 2 hours after you take the other medicine.

Many drugs can affect bosutinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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