Brenzavvy

Generic name: Bexagliflozin
Dosage form: tablets
Drug class: SGLT-2 inhibitors

Usage of Brenzavvy

Brenzavvy is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

Brenzavvy belongs to the class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by reducing renal reabsorption of filtered glucose and lowering the renal threshold for glucose, thereby increasing urinary glucose excretion.

Brenzavvy side effects

Brenzavvy may cause serious side effects, including:

See Important information.

serious urinary tract infections. Serious urinary tract infections that may lead to hospitalization have happened in people who are taking Brenzavvy. Tell your healthcare provider if you have signs or symptoms of a urinary tract infection such as a burning feeling when passing urine, a need to urinate often, the need to urinate right away, pain in the lower part of your stomach (pelvis), or blood in the urine. Sometimes people also may have a fever, back pain, nausea or vomiting.

low blood sugar (hypoglycemia). If you take Brenzavvy with another medicine that can cause low blood sugar such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered while you take Brenzavvy. Signs or symptoms of low blood sugar may include:

headache

drowsiness

hunger

irritability

dizziness

confusion

sweating

feeling jittery or shaky

weakness

fast heartbeat

a rare but serious bacterial infection that causes damage to the tissue under the skin (necrotizing fasciitis) in the area between and around the anus and genitals (perineum). Necrotizing fasciitis of the perineum has happened in people who take Brenzavvy. Necrotizing fasciitis of the perineum may lead to hospitalization, may require multiple surgeries, and may lead to death. Seek medical attention immediately if you have fever or you are feeling very weak, tired or uncomfortable (malaise) and you develop any of the following symptoms in the area between and around your anus and genitals:

pain or tenderness

swelling

redness of the skin (erythema)

The most common side effects include:

vaginal yeast infections

urinary tract infections

changes in urination, including urgent need to urinate more often, in larger amounts, or at night.

These are not all the possible side effect. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Brenzavvy

You should not take Brenzavvy if you:

are allergic to bexagliflozin or any of the other ingredients. See the end of this page for a list of ingredients. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing.

are on kidney dialysis.

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How to use Brenzavvy

Usual Adult Dose for Type 2 Diabetes

20 mg once daily, taken in the morning.

Use: adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Warnings

Brenzavvy can cause serious side effects, including:

Ketoacidosis (increased ketones in your blood or urine). Ketoacidosis has happened in people with type 1 diabetes treated with medicines like Brenzavvy or in people with type 2 diabetes during treatment with Brenzavvy. Ketoacidosis has also happened in people with diabetes who were sick or who had surgery during treatment with medicines like Brenzavvy. Ketoacidosis is a serious condition, which needs to be treated in a hospital. Ketoacidosis may lead to death. Ketoacidosis can happen with Brenzavvy even if your blood sugar is less than 250 mg/dL. Stop taking treatment and call your healthcare provider right away or go to the nearest hospital emergency room if you have any of the following symptoms:

nausea

vomiting

stomach-area (abdominal) pain

tiredness

trouble breathing

If you get any of these symptoms during treatment, if possible, check for ketones in your urine, even if your blood sugar is less than 250 mg/dL.

Amputations. Brenzavvy may increase your risk of lower limb amputations. Amputations mainly involve removal of the toe or part of the foot, however, amputations involving the leg, below and above the knee, have also occurred. Some people had more than one amputation. You may be at a higher risk of lower limb amputation if you:

have a history of amputation

have heart disease or are at risk for heart disease

have had blocked or narrowed blood vessels, usually in your leg

have damage to the nerves (neuropathy) in your leg

have had diabetic foot ulcers or sores

Call your healthcare provider right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your healthcare provider may decide to stop your treatment for a while if you have these signs or symptoms. Talk to your healthcare provider about proper foot care.

Dehydration. Brenzavvy can cause some people to become dehydrated (the loss of body water and salt). Dehydration can make you feel dizzy, faint, light-headed, or weak, especially when you stand up (orthostatic hypotension). There have been reports of sudden worsening of kidney function in people who are taking Brenzavvy. You may be at higher risk of dehydration if you:

have low blood pressure

take medicines that lower your blood pressure, including diuretics (water pills)

are on a low sodium (salt) diet

have kidney problems

are 65 years of age or older

Talk to your healthcare provider about what you can do to prevent dehydration including how much fluid you should drink on a daily basis. Talk to your healthcare provider right away if you reduce the amount of food or liquid you drink, for example if you are sick or cannot eat, or start to lose liquids from your body, for example from vomiting or diarrhea.

Vaginal yeast infection. Women who take Brenzavvy may get vaginal yeast infections. Yeast infections can be a serious but common side effect of taking Brenzavvy. Symptoms of a vaginal yeast infection include:

vaginal odor

white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese)

vaginal itching

Yeast infection of the penis (balanitis or balanoposthitis). Men who take Brenzavvy may get a yeast infection of the skin around the penis. Men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of the penis. Other symptoms of yeast infection of the penis include:

redness, itching, or swelling of the penis

rash of the penis

foul smelling discharge from the penis

pain in the skin around penis

Talk to your healthcare provider about what to do if you get symptoms of a yeast infection of the vagina or penis. Your healthcare provider may suggest you use an over-the-counter antifungal medicine. Talk to your healthcare provider as soon as possible if you use an over-the counter antifungal medication and your symptoms do not go away.

What other drugs will affect Brenzavvy

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Brenzavvy may affect the way other medicines work, and other medicines may affect how Brenzavvy works.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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