Brigatinib
Generic name: Brigatinib
Brand names: Alunbrig
Dosage form: oral tablet (180 mg; 30 mg; 90 mg; 90 mg-180 mg)
Drug class:
Multikinase inhibitors
Usage of Brigatinib
Brigatinib is used to treat non-small cell lung cancer that has spread to other parts of the body (metastatic) after other treatments have failed.
Brigatinib is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene). Your doctor will test you for this gene.
Brigatinib may also be used for purposes not listed in this medication guide.
Brigatinib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Brigatinib may cause serious side effects. Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of brigatinib may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Brigatinib
You should not use brigatinib if you are allergic to it.
Tell your doctor if you have ever had:
You may need to have a negative pregnancy test before starting this treatment.
Brigatinib can harm an unborn baby if the mother or the father is using brigatinib.
This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because brigatinib can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
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How to use Brigatinib
Usual Adult Dose for Non-Small Cell Lung Cancer:
Initial dose: 90 mg orally once a day for the first 7 daysMaintenance dose: 180 mg orally once a dayComments:-Patients should be selected for the treatment of metastatic NSCLC based on the presence of ALK positivity in tumor specimens.-FDA-approved test for the detection of ALK rearrangements in NSCLC is available at http://www.fda.gov/CompanionDiagnostic-Treatment should be continued until disease progression or unacceptable toxicity.Use: For treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test
Warnings
Brigatinib can cause serious side effects such as lung problems, vision problems, high blood pressure, high blood sugar, very slow heartbeats, muscle damage, or pancreatitis.
Call your doctor at once if you have side effects, such as: severe headache, confusion, feeling light-headed, blurred vision, seeing flashes of light or "floaters" in your vision, increased thirst or urination, hunger, nausea, upper stomach pain spreading to your back, unexplained muscle pain or weakness, fever, cough, chest pain, trouble breathing, very slow heartbeats, or feeling like you might pass out.
What other drugs will affect Brigatinib
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect brigatinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Popular FAQ
Yes, Alunbrig is the brand name product for brigatinib, a medicine used to treat non-small cell lung cancer that has spread in the body. Alunbrig, from Takeda Pharmaceuticals, was first approved in April 2017. There is no generic alternative for Alunbrig at this time.
Yes, Alunbrig is the brand name product for brigatinib, a medicine used to treat non-small cell lung cancer that has spread in the body. Alunbrig, from Takeda Pharmaceuticals, was first approved in April 2017. There is no generic alternative for Alunbrig at this time.
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