Bumetanide (Oral)

Generic name: Bumetanide
Drug class: Loop diuretics

Usage of Bumetanide (Oral)

Bumetanide belongs to a group of medicines called loop diuretics or "water pills." Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

This medicine is available only with your doctor's prescription .

Bumetanide (Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal pain

blurred vision

confusion

decreased urine output

dizziness

drowsiness

dry mouth

fast or irregular heartbeat

flushed, dry skin

fruit-like breath odor

headache

increased hunger

increased thirst

increased urination

irritability

joint pain, stiffness, or swelling

loss of appetite

loss of mental alertness

lower back, side, or stomach pain

mood or mental changes

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

shortness of breath

sweating

swelling of face, hands, feet, ankles, or lower legs

troubled breathing

unexplained weight loss

unusual tiredness or weakness

weak pulse

Rare

Agitation

back pain

black, tarry stools

bleeding gums

blood in the urine or stools

chest pain

convulsions (seizures)

deep or fast breathing with dizziness

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

fever

hallucinations

hives

increase in heart rate

increased blood pressure

numbness of feet, hands, and around the mouth

pinpoint red spots on the skin

rapid breathing

stiff neck

sunken eyes

trembling, jerking of hands

unusual bleeding or bruising

weight gain

wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Difficulty breathing

pain in chest, groin, or legs, especially the calves

severe, sudden headache

slurred speech

sudden loss of coordination

sudden, severe weakness or numbness in the arm or leg

sudden, unexplained shortness of breath

unusual drowsiness, dullness, or feeling of sluggishness

vision changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Decreased interest in sexual intercourse

diarrhea

difficulty with moving

ear discomfort

feeling of constant movement of self or surroundings

inability to have or keep an erection

itching skin

loss in sexual ability, desire, drive, or performance

muscle or bone pain

muscle stiffness

nipple tenderness

pain, swelling, or redness in joints

rash

sensation of spinning

shorter than usual time to ejaculation of semen

trouble with hearing

upset stomach

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Bumetanide (Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bumetanide in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of bumetanide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving bumetanide .

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Desmopressin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Albuterol

Amtolmetin Guacil

Arsenic Trioxide

Aspirin

Bepridil

Bromfenac

Bufexamac

Buprenorphine

Celecoxib

Choline Salicylate

Clonixin

Codeine

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Digitoxin

Dipyrone

Dofetilide

Droperidol

Droxicam

Etodolac

Etofenamate

Etoricoxib

Felbinac

Fenoprofen

Fepradinol

Feprazone

Floctafenine

Flufenamic Acid

Flurbiprofen

Formoterol

Foscarnet

Ibuprofen

Indomethacin

Ketanserin

Ketoprofen

Ketorolac

Levomethadyl

Lithium

Lornoxicam

Loxoprofen

Lumiracoxib

Meclofenamate

Mefenamic Acid

Meloxicam

Methotrexate

Metolazone

Morniflumate

Nabumetone

Naproxen

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Oxaprozin

Oxyphenbutazone

Parecoxib

Phenylbutazone

Piketoprofen

Piroxicam

Proglumetacin

Propyphenazone

Proquazone

Rofecoxib

Salicylic Acid

Salsalate

Sodium Salicylate

Sotalol

Sulindac

Tapentadol

Tenoxicam

Tiaprofenic Acid

Tolfenamic Acid

Tolmetin

Valdecoxib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Benazepril

Captopril

Cilazapril

Dibekacin

Enalapril

Enalaprilat

Fosinopril

Germanium

Ginseng

Gossypol

Kanamycin

Licorice

Lisinopril

Moexipril

Neomycin

Perindopril

Quinapril

Ramipril

Spirapril

Streptomycin

Trandolapril

Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

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How to use Bumetanide (Oral)

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For edema:

Adults—0.5 to 2 milligrams (mg) once a day. Your doctor may adjust your dose if needed.

Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects .

This medicine may cause you to lose more potassium from your body than normal. Your doctor will monitor the potassium in your blood while you are taking this medicine. To prevent the loss of too much water and potassium, tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea. Check with your doctor right away if you have one or more of these symptoms: dry mouth; increased thirst; muscle cramps; or nausea or vomiting .

Bumetanide can lower the number of platelets in your blood. Platelets are necessary for proper blood clotting. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin .

This medicine may cause changes in your blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .

Disclaimer

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