Bupropion and naltrexone
Generic name: Bupropion And Naltrexone
Brand names: Contrave
Dosage form: oral tablet, extended release (90 mg-8 mg)
Drug class:
Anorexiants
Usage of Bupropion and naltrexone
Bupropion is an antidepressant medicine that can also decrease appetite. Naltrexone is usually given to block the effects of opioids or alcohol in people with addiction problems. Naltrexone may also curb hunger and food cravings.
Bupropion and naltrexone is a combination medicine used to help manage weight in obese or overweight adults with weight-related medical problems. bupropion and naltrexone is used together with diet and exercise.
Bupropion and naltrexone will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol.
Contrave is not approved to treat depression or other psychiatric conditions, or to help you quit smoking.
Bupropion and naltrexone may also be used for purposes not listed in this medication guide.
Bupropion and naltrexone side effects
Get emergency medical help if you have signs of an allergic reaction: fever, swollen glands, mouth sores, muscle or joint pain; hives, rash or itching; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.
A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, severe drowsiness, or if you are hard to wake up.
Stop taking this medicine and call your doctor right away if you have:
Older adults may be more likely to have certain side effects.
Common side effects of bupropion and naltrexone may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Bupropion and naltrexone
Do not use this medicine if you are pregnant. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Tell your doctor right away if you become pregnant.
You should not use this medicine if you are allergic to bupropion or naltrexone, or if you have:
Do not use opioid medication for a minimum of 7 to 10 days before starting bupropion and naltrexone.
Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion and naltrexone. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Tell your doctor if you have ever had:
Some young people have thoughts about suicide when first taking bupropion. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
You should not breastfeed while using this medicine.
This medicine is not approved for use by anyone younger than 18 years old.
Relate drugs
- Contrave
- Belviq
- Belviq XR
- Bupropion and naltrexone
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- Lorcaserin
- Meridia
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- Phentermine and topiramate
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How to use Bupropion and naltrexone
Usual Adult Dose for Weight Loss:
Each extended-release tablet contains naltrexone 8 mg/bupropion 90 mg: Initial dose: -Week 1: One tablet orally once a day in the morning -Week 2: One tablet orally 2 times a day (morning and evening) -Week 3: Two tablets orally in the morning and 1 tablet orally in the evening -Week 4: Two tablets orally 2 times a day (morning and evening) Maintenance dose: 2 tablets orally 2 times a day (morning and evening) Maximum dose: 4 tablets/day (naltrexone 32 mg/bupropion 360 mg) Comments:-Therapy should be discontinued if a patient has not lost at least 5% of baseline body weight after 12 weeks at maintenance dose as it is unlikely that clinically meaningful weight loss will occur with continued treatment.-The effect of this drug on cardiovascular morbidity and mortality has not been established.-The safety and effectiveness of this drug in combination with other products intended for weight loss, including prescription drugs, over-the-counter drugs, and herbal preparations, have not been established.Uses: As an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia).
Warnings
You should not use bupropion and naltrexone if you have uncontrolled high blood pressure, seizures, an eating disorder, opioid addiction, if you are pregnant, if you take opioid medicine or other forms of bupropion, or if you have suddenly stopped using alcohol, seizure medication, or a sedative.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with bupropion and naltrexone, and some drugs should not be used together.
Some young people have thoughts about suicide when first taking bupropion. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
What other drugs will affect Bupropion and naltrexone
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
When you start or stop taking bupropion and naltrexone, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
Many drugs can affect bupropion and naltrexone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Popular FAQ
Weight gain is not a common side effect with oral naltrexone treatment. When used in combination with bupropion, naltrexone is approved to help promote weight loss. Naltrexone is known to frequently cause stomach side effects like nausea and vomiting, stomach pain or cramping, and loss of appetite which could contribute to weight loss. Weight gain and increased appetite have been reported as a possible side effect, but is not common. Continue reading
Weight gain is not a common side effect with oral naltrexone treatment. When used in combination with bupropion, naltrexone is approved to help promote weight loss. Naltrexone is known to frequently cause stomach side effects like nausea and vomiting, stomach pain or cramping, and loss of appetite which could contribute to weight loss. Weight gain and increased appetite have been reported as a possible side effect, but is not common. Continue reading
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