Bydureon

Generic name: Exenatide
Dosage form: Auto-injector
Drug class: Incretin mimetics

Usage of Bydureon

BCise" href="/drugs/bydureon-bcise-2242/">BYDUREON BCise is an extended release injectable diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin more efficiently.

Bydureon BCise is used together with diet and exercise to improve blood sugar control in people with type 2 diabetes mellitus. Bydureon BCise is for use in adults and children at least 10 years old.

Bydureon BCise is not for treating type 1 diabetes.

This medication guide provides information about Bydureon, the long acting form of exenatide. Byetta is another brand of exenatide that is not covered in this medication guide.

Bydureon Pen was discontinued in March 2021. Bydureon BCise Pen is still available. The Bydureon BCise product is an auto-injector that does not need to be mixed. It has a pre-attached hidden needle and contains the same active ingredient as Bydureon pen.

Bydureon side effects

Get emergency medical help if you have signs of an allergic reaction to Bydureon: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some people using exenatide have had serious or fatal bleeding caused by low levels of platelets (blood cells that help your blood to clot). Stop using Bydureon and call your doctor right away if you have unusual bleeding or bruising.

Stop using Bydureon BCise and call your doctor at once if you have:

  • severe ongoing nausea and vomiting;
  • pain, warmth, swelling, an open wound or scab, or other skin changes where the injection was given;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • signs of a thyroid tumor - swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath;
  • pancreas or gallbladder problems - pain in your upper stomach spreading to your back, nausea and vomiting, fever, fast heart rate, yellowing of your skin or eyes;
  • low blood sugar - headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or
  • kidney problems - swelling, urinating less, feeling tired or short of breath.

    • Common Bydureon side effects may include:

  • indigestion, nausea, vomiting, diarrhea, constipation;
  • headache; or
  • itching or a small bump where an injection was given.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Bydureon

    You should not use Bydureon if you are allergic to exenatide, or if you have:

  • multiple endocrine neoplasia type 2 (tumors in your glands);
  • a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or
  • a history of low levels of platelets (blood cells that help your blood to clot) while using exenatide.

    • To make sure Bydureon BCise is safe for you, tell your doctor if you have::

  • kidney disease, or a kidney transplant;
  • a stomach disorder that causes slow digestion;
  • pancreatitis; or
  • gallbladder disease.

    • Bydureon has caused thyroid tumors in animal studies. It is not known if this could occur in humans. Ask your doctor about the risk.

    Follow your doctor's instructions about using Bydureon BCise if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

    Ask a doctor if it is safe to breastfeed while using this medicine.

    Bydureon is not approved for use by anyone younger than 10 years old.

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    How to use Bydureon

    Usual Adult Dose of Bydureon BCisefor Diabetes Type 2:

    Extended-release: Initial dose - 2 mg subcutaneously once every 7 days (weekly) -May administer any time of day, with or without meals; see dose adjustments for information on missed doses and changing administration day -Prior treatment with immediate-release product is not required; for patients who do switch, discontinue immediate-release at initiation of extended-release; transient blood glucose elevations may occur for approximately 2 to 4 weeks after switch -Switching extended-release products may be done at next regularly scheduled dose Comments: -This drug has not been studied in patients with a history of pancreatitis and therefore, other therapies should be considered in these patients. -Extended-release exenatide is not recommended as first-line therapy because of the uncertainty of the risk of thyroid C-cell tumors. -Patients may experience transient (approximately 2 to 4 weeks) elevation in blood sugar when switching from immediate-release exenatide to extended-release.

    Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

    Usual Pediatric Dose for Diabetes Type 2:

    10 years and older: Extended-release: 2 mg subcutaneously once every 7 days (weekly) -May administer any time of day, with or without meals; see dose adjustments for information on missed doses and changing administration day Comments: -Extended-release exenatide is not recommended as first-line therapy because of the uncertainty of the risk of thyroid C-cell tumors. -This drug is not indicated for use in patients with type 1 diabetes. -This drug has not been studied in patients with a history of pancreatitis and therefore, other therapies should be considered in these patients. Use: As an adjunct to diet and exercise to improve glycemic control in pediatric patients 10 years and older with type 2 diabetes mellitus.

    Warnings

    You should not use Bydureon BCise if you have a personal or family history of thyroid cancer, if you have multiple endocrine neoplasia type 2 (MEN 2, a cancer that can affect the thyroid, parathyroid, and adrenal glands), or if you have ever had low platelets while using exenatide.

    Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath.

    You should not use Bydureon BCise if exenatide has ever caused you to have low platelet levels in your blood.

    Stop using Bydureon BCise and call your doctor at once if you have severe pain in your upper stomach spreading to your back, with nausea, vomiting, and a fast heart rate. These could be symptoms of pancreatitis.

    Do not use this medicine to treat type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

    Bydureon BCise is an extended-release form of exenatide administered as an injection once every seven days. The dose can be administered at any time of day, with or without meals. Follow your doctor's instructions.

    What other drugs will affect Bydureon

    Tell your doctor if you use insulin.

    Exenatide can make it harder for your body to absorb other medicines you take by mouth. Tell your doctor about all your other medicines, especially:

  • oral diabetes medicine;
  • blood pressure medicine;
  • warfarin (Coumadin, Jantoven);
  • diuretic or "water pill"; or
  • a pain medicine.

    • This list is not complete. Other drugs may interact with exenatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Popular FAQ

    The Bydureon pen was discontinued in March 2021 and has been replaced by Bydureon Bcise Autoinjector. The Bydureon BCise autoinjector is easy to use and can be self-injected at home once a week. If you have trouble injecting it yourself, you could ask a family member, friend, caregiver, or your health provider to do it for you. Bydureon BCise is injected subcutaneously (this means just under the skin) and there are 3 main areas where it can be injected: The stomach area (your belly) except for a 2-inch circle around your navel (belly button) The top and outer part of your thighs, but not your inner thighs or anywhere close to your knee The outer back of your upper arm where there is a pocket of fatty tissue (this is usually easier if somebody else is giving you the injection). Continue reading

    Bydureon Bcise starts working as soon as you inject the first dose but it may take two or more weeks before it has a noticeable effect on your blood sugar, and longer before it decreases your HbA1c levels. Bydureon Bcise builds up gradually in your body with each weekly dose and reaches its optimal level after 10 weeks of dosing. The extended-release delivery system keeps a consistent level of medicine in your body. Continue reading

    Bydureon can be left unrefrigerated at room temperature for up to 4 weeks (28 days) as long as the temperature in the room does not exceed 86°F (30°C). This will allow you to take your weekly dose with you, especially if you are traveling. Never leave your Bydureon pen in the sun or a hot place, like your car's jockey box, because it will become too hot. And do not put it back in the refrigerator if it has been out of the refrigerator for longer than an hour. Continue reading

    Bydureon works by mimicking the effects of a naturally occurring human incretin, called GLP-1. Incretins are gut-derived hormones, similar to glucagon, that are released in response to food ingestion, mainly when we eat glucose or fat. When GLP-1 binds to the GLP-1 receptor it causes an increase in our body’s production of insulin in response to food. When Bydureon is given by injection into the upper thigh once a week, it binds to the GLP-1 receptor, stimulating insulin release from the beta cells of the pancreas whenever we eat. Continue reading

    The Bydureon Bcise Autoinjector has been designed to be easy to use. There is no need to attach a needle (the hidden needle is already attached) or turn a dial. Always store your Bydureon Bcise autoinjector flat in the refrigerator. Continue reading

    The Bydureon pen was discontinued in March 2021 and has been replaced by Bydureon Bcise Autoinjector. The Bydureon Bcise Autoinjector has been designed to be easy to use. There is no need to attach a needle (the hidden needle is already attached) or turn a dial. Always store your Bydureon Bcise autoinjector flat in the refrigerator. It can be self-injected at home once a week and it is easy to learn how to administer it yourself. If you have difficulty injecting it, a family member, friend, caregiver, or healthcare provider may be able to do it for you. Instructions for injecting the Bydureon Bcise autoinjector are given below. Continue reading

    The Bydureon pen was discontinued in March 2021 and has been replaced by Bydureon Bcise Autoinjector. The Bydureon BCise autoinjector is easy to use and can be self-injected at home once a week. If you have trouble injecting it yourself, you could ask a family member, friend, caregiver, or your health provider to do it for you. Bydureon BCise is injected subcutaneously (this means just under the skin) and there are 3 main areas where it can be injected: The stomach area (your belly) except for a 2-inch circle around your navel (belly button) The top and outer part of your thighs, but not your inner thighs or anywhere close to your knee The outer back of your upper arm where there is a pocket of fatty tissue (this is usually easier if somebody else is giving you the injection). Continue reading

    Bydureon Bcise starts working as soon as you inject the first dose but it may take two or more weeks before it has a noticeable effect on your blood sugar, and longer before it decreases your HbA1c levels. Bydureon Bcise builds up gradually in your body with each weekly dose and reaches its optimal level after 10 weeks of dosing. The extended-release delivery system keeps a consistent level of medicine in your body. Continue reading

    Bydureon can be left unrefrigerated at room temperature for up to 4 weeks (28 days) as long as the temperature in the room does not exceed 86°F (30°C). This will allow you to take your weekly dose with you, especially if you are traveling. Never leave your Bydureon pen in the sun or a hot place, like your car's jockey box, because it will become too hot. And do not put it back in the refrigerator if it has been out of the refrigerator for longer than an hour. Continue reading

    Bydureon works by mimicking the effects of a naturally occurring human incretin, called GLP-1. Incretins are gut-derived hormones, similar to glucagon, that are released in response to food ingestion, mainly when we eat glucose or fat. When GLP-1 binds to the GLP-1 receptor it causes an increase in our body’s production of insulin in response to food. When Bydureon is given by injection into the upper thigh once a week, it binds to the GLP-1 receptor, stimulating insulin release from the beta cells of the pancreas whenever we eat. Continue reading

    The Bydureon Bcise Autoinjector has been designed to be easy to use. There is no need to attach a needle (the hidden needle is already attached) or turn a dial. Always store your Bydureon Bcise autoinjector flat in the refrigerator. Continue reading

    The Bydureon pen was discontinued in March 2021 and has been replaced by Bydureon Bcise Autoinjector. The Bydureon Bcise Autoinjector has been designed to be easy to use. There is no need to attach a needle (the hidden needle is already attached) or turn a dial. Always store your Bydureon Bcise autoinjector flat in the refrigerator. It can be self-injected at home once a week and it is easy to learn how to administer it yourself. If you have difficulty injecting it, a family member, friend, caregiver, or healthcare provider may be able to do it for you. Instructions for injecting the Bydureon Bcise autoinjector are given below. Continue reading

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