Caffeine and ergotamine oral/rectal

Generic name: Caffeine And Ergotamine (oral/rectal)
Drug class: Antimigraine agents

Usage of Caffeine and ergotamine oral/rectal

Caffeine is a stimulant that causes narrowing of blood vessels (vasoconstriction). Ergotamine is an ergot alkaloid (ER-got AL-ka-loid) that works by narrowing blood vessels around the brain.

Caffeine and ergotamine is a combination medicine used to treat or prevent a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Caffeine and ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Caffeine and ergotamine may also be used for purposes not listed in this medication guide.

Caffeine and ergotamine oral/rectal side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Caffeine and ergotamine may cause serious side effects. Stop using caffeine and ergotamine and call your doctor at once if you have:

severe pain in your stomach or back;

bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

cramps in your hips or legs, leg pain or swelling;

weak pulses in your arms and legs, numbness and tingling or pain in your hands or feet, blue-colored fingers or toes;

muscle pain or weakness in your arms or legs;

fast or slow heart rate;

severe headache, blurred vision, pounding in your neck or ears;

sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or

painful sores on your rectum after using the rectal suppositories.

Serious side effects are more likely with overuse of caffeine and ergotamine. caffeine and ergotamine is not for daily use.

Common side effects of caffeine and ergotamine may include:

numbness, tingling, burning pain;

dizziness, spinning sensation;

weakness;

itching or swelling;

nausea, vomiting; or

(with suppository use) a rectal sore or ulcer.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Caffeine and ergotamine oral/rectal

You should not use caffeine and ergotamine if you are allergic to caffeine or ergotamine, or if you have:

coronary heart disease;

high blood pressure;

blood circulation problems;

sepsis (a severe reaction to an infection);

liver disease;

kidney disease; or

if you are pregnant or could become pregnant.

Many drugs can cause a dangerous decrease in blood flow when used with caffeine and ergotamine. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects. Some drugs should not be used together with caffeine and ergotamine. Your doctor may change your treatment plan if you also use:

zileuton;

an antidepressant--fluoxetine, fluvoxamine, Nefazodone;

an antibiotic--clarithromycin, erythromycin, metronidazole, Telithromycin;

antifungal medicine--clotrimazole, fluconazole, itraconazole, ketoconazole; or

antiviral medicine to treat HIV/AIDS--Indinavir, Nelfinavir, ritonavir, Saquinavir.

Do not use caffeine and ergotamine if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and tell your doctor if you become pregnant.

You should not breastfeed while using this medicine.

Relate drugs

How to use Caffeine and ergotamine oral/rectal

Usual Adult Dose for Migraine:

Oral: Ergotamine 1 mg-caffeine 100 mg per tablet: Initial dose: 2 tablets orally at first sign of an attack; 1 additional tablet every half-hour as needed not to exceed maximum doses Maximum doses: 6 tablets per attack; 10 tablets per 7-day periodRectal: Ergotamine 2 mg-caffeine 100 mg per suppository: Initial dose: 1 suppository rectally at first sign of a migraine attack; 1 additional suppository may be administered after 1 hour if needed for full reliefMaximum dose: 2 suppositories per attack; 5 suppositories per 7-day periodComments:-Early administration at onset provides maximum effectiveness. -This drug should not be used for chronic daily administration. Use: To abort or prevent vascular headaches, such as a migraine, migraine variants, or "histaminic cephalalgia".

Warnings

Some medicines can cause a dangerous decrease in blood flow when used with caffeine and ergotamine. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects.

You should not use this medicine if you have coronary heart disease, high blood pressure, circulation problems, liver or kidney disease, or sepsis.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Do not use if you are pregnant or could become pregnant.

What other drugs will affect Caffeine and ergotamine oral/rectal

Tell your doctor about all your current medicines. Many drugs can affect caffeine and ergotamine, especially:

nicotine gum or skin patch;

an antibiotic or antifungal medicine;

diet pills, stimulants, or medicine to treat attention deficit hyperactivity disorder (ADHD);

heart or blood pressure medicine; or

medicines to treat asthma, colds or allergies.

This list is not complete and many other drugs may affect caffeine and ergotamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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