Calanolide A

Generic name: Calophyllum Lanigerum Var. Austrocoriaceum
Brand names: Calanolide A

Usage of Calanolide A

Antimicrobial activity

In vitro data

An in vitro study investigated the activity of modified Calanolides against Mycobacterium tuberculosis.(Liu 2015)

Antiviral activity

Early interest persists in using Calophyllum extracts in the management of HIV infections,(Matthée 1999, Newman 1998) particularly for clinically relevant mUTAnt HIV strains.(Usach 2013) Calanolide A and related compounds from the genus Calophyllum have demonstrated antiviral activity, including nonnucleoside reverse transcriptase inhibition(Matthée 1999, Newman 1998) and activity against influenza H3N1 and H1N1 viruses.(Rajasekaran 2013)

Animal and in vitro data

Calanolide A has demonstrated synergistic effects with other anti-HIV drugs in cell and animal models.(Nahar 2020)

Clinical data

Published clinical research on C. lanigerum is lacking. Calanolide A has been investigated in phase 1 clinical trials to evaluate safety, tolerability, and pharmacokinetics.(Creagh 2001, Usach 2013) In 2016, Craun Research announced that phase 1 trials with calanolide A had been completed.(Nahar 2020)

Cancer

Calanolide A is being investigated as an antitumor agent.(Defant 2015, Nahar 2020)

Calanolide A side effects

Because calanolide A is a relatively new product, data are limited regarding potential adverse Reactions. An early phase 1 single-dose safety and pharmacokinetic clinical trial in healthy subjects demonstrated a favorable safety profile.(Creagh 2001, Usach 2013)

Before taking Calanolide A

Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.

How to use Calanolide A

Clinical data are lacking to provide dosing recommendations for C. lanigerum or its extracts.

Calanolide A is an investigational anti-HIV drug that has been evaluated in early phase 1 single-dose safety and pharmacokinetic clinical trials in healthy subjects (oral dose range, 200 to 800 mg); however, safety and efficacy remain to be defined, and calanolide A is not available for use.(Creagh 2001, Nahar 2020)

Calanolides are associated with high safety margins and favorable pharmacokinetic profiles; while several analogues of the naturally occurring calanolides have been synthesized, further research is required to commercially bring any of the calanolide candidates, natural or synthetic, to the anti-HIV drug market.(Nahar 2020)

Warnings

Information is limited. Animal studies demonstrated that oral calanolide A is generally well tolerated in doses of up to 150 mg/kg in rats and 100 mg/kg in dogs. In a study of healthy patients without HIV, there were no serious or toxic effects with calanolide A use.(Nahar 2020)

What other drugs will affect Calanolide A

None well documented.

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