Camzyos
Generic name: Mavacamten
Dosage form: capsules (2.5mg, 5mg, 10mg, 15mg)
Drug class:
Miscellaneous cardiovascular agents
Usage of Camzyos
Camzyos (mavacamten) is used for obstructive hypertrophic cardiomyopathy (HCM) to improve shortness of breath and the ability to be active. Camzyos works by allowing your heart muscle to relax, which reduces the obstruction and improves overall heart function. Obstructive hypertrophic cardiomyopathy (HCM) occurs when the walls of the heart become excessively thickened, leading to an obstruction in the outflow of the left ventricle which reduces the heart's ability to pump blood effectively.
Camzyos is an allosteric and reversible inhibitor selective for cardiac myosin. Myosin is a protein in the heart muscle that is involved in making the heart muscle contract and relax. When Camzyos binds to myosin, the heart muscle relaxes more, so the heart fills with blood and is able to pump more effectively.
Camzyos became an FDA-approved medicine on April 28, 2022, for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms.
Camzyos side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Camzyos may cause serious side effects. Call your doctor at once if you have:
Common side effects of Camzyos may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Camzyos
Some drugs should not be used with Camzyos. Your treatment plan may change if you also use:
Tell your doctor if you have ever had:
Pregnancy
Camzyos may harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant for using this medicine. Use effective birth control while using this medicine and for at least 4 months after your last dose. Tell your doctor if you become pregnant.
Camzyos can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.
Breastfeeding
Ask a doctor if it is safe to breastfeed while using Camzyos.
Relate drugs
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- Orvaten
- Phenoxybenzamine
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How to use Camzyos
Usual Adult Dosage for Hypertrophic Cardiomyopathy
Starting dose: 5 mg orally once a day
Allowable subsequent doses with titration: 2.5, 5, 10, or 15 mg orally once a day
Comments
Available Strengths
Warnings
Camzyos may cause serious side effects, including:
Heart failure:
Heart failure is a condition where the heart cannot pump with enough force. Heart failure is a serious condition that can lead to death. You must have echocardiograms before you take the first dose and also during your treatment with this medicine. This is important to help your healthcare provider understand how your heart is responding to this medicine. People who develop a serious infection or irregular heartbeat have a greater risk of heart failure during treatment. Call your doctor at once if you have shortness of breath, chest pain, tiredness, swelling in your legs, rapid weight gain, or racing or pounding heartbeats.
The risk of heart failure is also increased when Camzyos is taken with certain other medicines. Tell your healthcare provider about the medicines you take, both prescribed and obtained over-the-counter, before and during treatment.
Because of the serious risk of heart failure, this medicine is only available through a restricted program called the Camzyos Risk Evaluation and Mitigation Strategy (REMS) Program.
See Camzyos side effects for information about side effects.
What other drugs will affect Camzyos
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect Camzyos, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Click on the link below to check for interactions with Camzyos.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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