Canakinumab
Generic name: Canakinumab
Brand names: Ilaris
Dosage form: subcutaneous solution (150 mg/mL)
Drug class:
Interleukin inhibitors
Usage of Canakinumab
Canakinumab is a monoclonal antibody that blocks certain proteins in the body that can affect inflammation and other immune responses. Canakinumab is used to treat certain types of periodic fever syndromes, sometimes called auto-inflammatory syndromes.
Periodic fever syndromes are rare and often inherited conditions caused by mUTAtions in certain genes; usually genes that are involved in producing a certain protein or enzyme in the body. People with a periodic fever syndrome have episodes of fever and inflammation without other causes such as infection or virus.
Canakinumab is used to treat the following periodic fever syndromes in adults and children who are at least 4 years old:
Canakinumab is also used to treat Still's disease including Adult-Onset Still's Disease and Systemic Juvenile Idiopathic Arthritis in children who are at least 2 years old.
Canakinumab may also be used for purposes not listed in this medication guide.
Canakinumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; nausea, trouble swallowing; dizziness, fast or pounding heartbeats, difficult breathing; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur during treatment with canakinumab. Call your doctor right away if you have signs of infection such as:
Common side effects of canakinumab may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Canakinumab
You should not use canakinumab if you are allergic to canakinumab.
Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.
Tell your doctor if you have ever had:
Make sure you are current on all vaccines before you begin treatment with canakinumab.
Treatment with canakinumab may increase your risk of developing cancer. Talk to your doctor about your individual risk.
Tell your doctor if you are pregnant or plan to become pregnant.
If you use canakinumab while you are pregnant, make sure any doctor caring for your new baby knows that you used the medicine during pregnancy. Being exposed to canakinumab in the womb could affect your baby's vaccination schedule during the first 12 months of life.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Relate drugs
- Actemra
- Actemra ACTPen
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- Arcalyst
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- Basiliximab
- Benralizumab
- Brodalumab
- Canakinumab
- Cinqair
- Daclizumab
- Dupilumab
- Dupixent
- Dupixent Pre-filled Pen
- Dupixent Pre-filled Syringe
- Enspryng
- Fasenra
- Fasenra Pen
- Fasenra Prefilled Syringe
- Guselkumab
- Ilaris
- Ilumya
- Ixekizumab
- Mepolizumab
- Nucala
- Reslizumab
- Rilonacept
- Risankizumab
- Risankizumab-rzaa
- Satralizumab
- Satralizumab-mwge
- secukinumab
- Siliq
- Siltuximab
- Simulect
- Skyrizi
- Skyrizi Pen
- Spesolimab
- Spesolimab-sbzo
- Spevigo
- Stelara
- Sylvant
- Taltz
- Tildrakizumab
- Tildrakizumab-asmn
- Tocilizumab
- Tralokinumab
- Tralokinumab-ldrm
- Tremfya
- Ustekinumab
- Zinbryta
How to use Canakinumab
Before you start treatment with canakinumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Canakinumab is injected under the skin. A healthcare provider will give you this injection.
Canakinumab is usually given once every 4 to 8 weeks Depending on the condition being treated. Follow your doctor's instructions.
Tell your doctor if you have any changes in weight. Canakinumab doses are based on weight (especially in children and teenagers), and any changes may affect the dose.
Canakinumab can weaken your immune system. Your blood may need to be tested often.
Warnings
Serious and sometimes fatal infections may occur during treatment with canakinumab. Call your doctor right away if you have signs of infection such as: fever, chills, sweating, tiredness, cough, shortness of breath, skin sores, warm or painful areas on your body, diarrhea, stomach pain, or weight loss.
What other drugs will affect Canakinumab
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect canakinumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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