Canasa
Generic name: Mesalamine
Dosage form: rectal suppository
Drug class:
5-aminosalicylates
Usage of Canasa
Canasa (mesalamine) is a suppository used to treat a type of inflammatory bowel disease called ulcerative proctitis. Ulcerative proctitis causes inflammation, redness and ulcers to develop in the lining of the rectum, which is at the end of your large intestine. Ulcerative proctitis may also affect nearby parts of the colon.
Canasa contains the medication mesalamine, which is also known as mesalazine or 5-aminosalicylic acid (5-ASA). It is contained inside a base of hard fat. Canasa is used topically and is inserted into the rectum. As the warmth of your body melts the hard fat base, the drug is released into the area where it needs to work.
Canasa belongs to a class of drugs called aminosalicylates. Canasa is thought to work by reducing inflammation in the epithelial cells that line the colon. Its anti-inflammatory action may result from its ability to block the enzyme cyclooxygenase (COX) and inhibit prostaglandin production in the colon. COX and prostaglandins (a group of lipids) are both involved in generating an inflammatory response.
Medications containing mesalamine have been available for many years, however, Canasa was first approved by the US Food and Drug Administration (FDA) in 2001.
When Canasa was first approved it was available as a 500 mg strength suppository that needed to be used twice a day. This has been replaced by a 1000 mg strength suppository that only needs to be used at night. Generic versions of Canasa are also available.
Canasa side effects
Canasa may cause serious side effects, including:
The most common side effects of Canasa include:
These are not all of the possible side effects of Canasa.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Canasa
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Canasa can harm your unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed. Canasa can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you use Canasa.
Relate drugs
- Balsalazide
- Canasa
- Canasa Pac rectal
- Delzicol
- Dipentum
- Giazo
- Lialda
- Mesalamine
- Mesalamine (Oral)
- Mesalamine rectal
- Olsalazine
- Pentasa
- Rowasa
- SfRowasa
- SfRowasa rectal
How to use Canasa
The recommended dose of Canasa for adults is 1000 mg administered rectally once daily at bedtime for 3 to 6 weeks. Safety and effectiveness beyond 6 weeks have not been established.
See full prescribing information for more information about Canasa dosing.
Warnings
Canasa is for rectal use only. Do not take Canasa by mouth.
What other drugs will affect Canasa
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
Using Canasa with certain other medicines may affect each other. Using Canasa with other medicines can cause serious side effects.
Especially tell your doctor if you take nonsteroidal anti-inflammatory drugs (NSAIDS), or medicines that contain azathioprine or 6-Mercaptopurine. Taking Canasa with NSAIDS may cause kidney problems. Taking Canasa with azathioprine or 6-mercaptopurine may cause blood problems. Ask your doctor if you are not sure if you are taking one of these medicines.
Your doctor may do certain tests during treatment with Canasa.
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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