Cantharidin (Topical)
Brand names: Ycanth
Drug class:
Antineoplastic Agents
Usage of Cantharidin (Topical)
Cantharidin has the following uses:
Cantharidin topical solution is indicated for the treatment of molluscum contagiosum in adult and pediatric patients 2 years of age and older.
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How to use Cantharidin (Topical)
General
Cantharidin is available in the following dosage form(s) and strength(s):
Topical solution containing 0.7% cantharidin; supplied in a glass ampule contained within a single-use applicator.
Dosage
It is essential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
All healthcare professionals should receive instruction and training prior to preparation and administration of cantharidin.
Use nitrile or vinyl gloves and eye protection during preparation and administration.
For topical use only. Not for oral, mucosal, or ophthalmic use.
Pediatric Patients
Adults
Dosage and AdministrationWarnings
Contraindications
None
Warnings/Precautions
Toxicities Associated with Inappropriate Administration
Cantharidin is for topical use only. Cantharidin is not for oral, mucosal, or ophthalmic use.
Life threatening or fatal toxicities can occur if cantharidin is administered orally. Adverse reactions to oral ingestion of cantharidin have included renal failure, blistering and severe damage to the gastrointestinal tract, coagulopathy, seizures, and flaccid paralysis. Advise patients and/or caregivers to avoid oral contact and to avoid touching lesions after cantharidin treatment and to seek medical attention immediately if cantharidin is accidently ingested.
Ocular toxicity can occur if cantharidin comes in contact with the eyes. Adverse reactions from contact of cantharidin with the eyes can include corneal necrosis, ocular perforation, and deep ocular injuries. Do not apply cantharidin near or to the eyes. If cantharidin comes in contact with the eyes, flush eyes with water for at least 15 minutes and seek medical attention immediately.
Local Skin Reactions
Cantharidin is a vesicant. Local skin reactions at the application site were observed in 97% of subjects treated with cantharidin during clinical trials. Local skin reactions included vesiculation, pruritus, pain, discoloration, and erythema.
Avoid application near the eyes and mucosal tissues, and to adjacent healthy skin. If cantharidin contacts any unintended surface, including healthy skin, immediately remove by wiping with a cotton swab or gauze.
Avoid other topical products (e.g., creams, lotions, or sunscreen) on treated areas until 24 hours after cantharidin treatment or until washing. Application of other topical products could spread cantharidin and cause blistering or other adverse reactions to healthy skin.
If severe blistering, severe pain or other severe adverse reactions occur, remove cantharidin prior to the recommended 24 hours after administration by washing with soap and water.
Flammability
Cantharidin is a flammable liquid, even after drying. Avoid fire, flame or smoking near lesion(s) during treatment and after application until removed.
Specific Populations
PregnancyThere are no available data with use of cantharidin in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. Animal reproduction studies were not conducted with cantharidin. Given that systemic exposure to cantharidin following topical administration is low, maternal use is not expected to result in fetal exposure to the drug.
The background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.
LactationAvoid application of cantharidin topical solution to areas with increased risk for potential ingestion by or ocular exposure to the breastfeeding child. There are no data on the presence of cantharidin in either human or animal milk, or the effects on the breastfed infant or on milk production. Breastfeeding is not expected to result in exposure of the child to the drug due to the low systemic absorption of cantharidin following topical administration. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for cantharidin topical solution and any potential adverse effects on the breastfeeding child from cantharidin topical solution or from the underlying maternal condition.
Pediatric UseThe safety and effectiveness of cantharidin for the treatment of molluscum contagiosum have been established in pediatric patients 2 years of age and older. The use of cantharidin in pediatric patients is supported by results from adequate and well-controlled trials in patients 2 years of age and older; although the safety and efficacy of drug use for longer than 12 weeks has not been established.
The safety and efficacy in pediatric patients below the age of 2 years have not been established.
Geriatric UseCantharidin has not been studied in geriatric patients.
Common Adverse Effects
Most common (incidence ≥1%) adverse reactions include the following local skin reactions at the application site: vesiculation, pain, pruritus, scabbing, erythema, discoloration, application site dryness, edema, and erosion.
What other drugs will affect Cantharidin (Topical)
Specific Drugs
It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:
Please see product labeling for drug interaction information.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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