Capecitabine

Generic name: Capecitabine
Brand names: Xeloda
Dosage form: oral tablet (150 mg; 500 mg)
Drug class: Antimetabolites

Usage of Capecitabine

Capecitabine is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Capecitabine is sometimes used when cancer has spread to other parts of the body (metastatic).

Capecitabine may also be used for purposes not listed in this medication guide.

Capecitabine side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Diarrhea may occur and could be severe. Stop taking capecitabine and tell your doctor right away if the number of bowel movements you usually have per day increases by 4 or more, or if you have bowel movements at night.

Capecitabine may cause serious side effects. Stop using capecitabine and call your doctor at once if you have:

  • severe diarrhea;
  • bloody diarrhea with severe stomach pain and fever;
  • severe nausea or loss of appetite that causes you to eat much less than usual;
  • vomiting (more than once in 24 hours);
  • fever above 100.5 degrees;
  • sores or ulcers in your mouth, redness or swelling of your mouth or tongue, trouble eating or swallowing;
  • jaundice (yellowing of the skin or eyes);
  • dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • "hand and foot syndrome"--pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet;
  • heart problems--chest pain, irregular heartbeats, swelling in your lower legs, rapid weight gain, feeling lightheaded or short of breath; or
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

    • Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

    Common side effects of capecitabine may include:

  • nausea, vomiting, diarrhea, stomach pain;
  • feeling weak or tired;
  • hand and foot syndrome; or
  • jaundice.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Capecitabine

    You should not take capecitabine if you are allergic to capecitabine or fluorouracil, or if you have:

  • severe kidney disease.

    • Tell your doctor if you have ever had:

  • a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency;
  • liver or kidney disease;
  • heart problems; or
  • if you use a blood thinner and you have routine "INR" or prothrombin time tests.

    • Capecitabine can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose.
  • If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs.

    • Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

    Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

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    How to use Capecitabine

    Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

    Capecitabine is usually taken twice per day, and may be only part of a treatment program that may also include other medications taken on different schedules. Follow your doctor's dosing instructions very carefully.

    Take with food or within 30 minutes after eating a meal.

    Swallow the tablet whole with water and do not crush, chew, or break it. Tell your doctor if you have trouble swallowing the tablet.

    Capecitabine is given in a 3-week treatment cycle, and you may only need to take the medicine only on certain days of this cycle.

    You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea.

    You may need frequent medical tests and your cancer treatments may be delayed based on the results. Capecitabine can have long lasting effects on your body. You may also need medical tests for a short time after your last dose.

    Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

    Warnings

    Taking a blood thinner (warfarin, Coumadin, Jantoven) can increase your risk of severe bleeding during and shortly after treatment with capecitabine. This risk is higher in adults older than 60.

    What other drugs will affect Capecitabine

    Taking a blood thinner (warfarin, Coumadin, Jantoven) can increase your risk of severe bleeding during and shortly after treatment with capecitabine. This risk is higher in adults older than 60.

    Tell your doctor if you also take allopurinol.

    Other drugs may affect capecitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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