Carbamide Peroxide
Drug class: Antineoplastic Agents , Antineoplastic Agents
Usage of Carbamide Peroxide
Cerumen Removal
Occasional aid to soften, loosen, and remove excessive cerumen (earwax) from external ear canal.
Oral Irritation and Inflammation
Oral debriding agent and oral wound cleanser for topical treatment of canker sores (aphthous ulcers) and minor wounds or gum inflammation resulting from minor dental procedures, dentures, orthodontic appliances, accidental injury, or other irritations of the mouth and gums.
Aid in removal of phlegm, mucus, or other secretions associated with occasional sore mouth.
Adjunct to oral hygiene when normal cleansing measures are inadequate or impossible (e.g., total-care geriatric patients) or adjunct to oral hygiene after regular brushing.
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How to use Carbamide Peroxide
Administration
Otic Administration
Instill into external ear canal as a 6.5% otic solution.
For topical otic use only.
Avoid contact with eyes. If contact with eyes occurs, flush eyes with water and consult clinician.
Remove hearing aids before administering the otic solution.
Tilt head sideways and instill 5–10 drops of otic solution into ear; do not insert applicator tip into ear canal.
Keep solution in ear canal for several minutes by maintaining tilted head or placing cotton or an ear plug in the ear.
Foaming may occur in ear canal and crackling sound may be heard when otic solution contacts earwax and oxygen is released.
Recap otic solution container after each use.
Any earwax remaining after treatment may be removed by gently flushing ear canal with warm water using soft rubber bulb ear syringe.
Oral, Topical Use Only
Apply 10% oral topical solution to mouth only; do not swallow the oral topical solution.
Avoid contact with eyes.
Do not dilute.
Apply oral topical solution directly from bottle onto affected mouth area(s); expectorate after 2–3 minutes.
Alternatively, use oral topical solution as a mouth rinse by placing 10–20 drops onto tongue, mixing the solution with saliva by swishing it around in mouth over affected area(s) for at least 1 minute, and expectorating.
Dosage
Pediatric Patients
Cerumen Removal OticChildren ≥12 years of age: Instill 5–10 drops of 6.5% otic solution into external ear canal twice daily for up to 4 days or as directed by clinician. (See Otic Administration under Dosage and Administration.)
Oral Irritation and Inflammation Oral TopicalChildren ≥2 years of age: For direct application, apply several drops of 10% oral topical solution to affected mouth area(s) up to 4 times daily, after meals and at bedtime, or as directed by clinician (dentist or physician). (See Oral, Topical Use Only under Dosage and Administration.)
Children ≥2 years of age: As an oral rinse, apply 10–20 drops of 10% oral topical solution onto tongue up to 4 times daily, after meals and at bedtime, or as directed by clinician. (See Oral, Topical Use Only under Dosage and Administration.)
Adults
Cerumen Removal OticInstill 5–10 drops of 6.5% otic solution into external ear canal twice daily for up to 4 days or as directed by clinician. (See Otic Administration under Dosage and Administration.)
Oral Irritation and Inflammation Oral TopicalDirect application: Apply several drops of 10% oral topical solution to affected mouth area(s) up to 4 times daily, after meals and at bedtime, or as directed by clinician (dentist or physician). (See Oral, Topical Use Only under Dosage and Administration.)
Oral rinse: Apply 10–20 drops of 10% oral topical solution onto tongue up to 4 times daily, after meals and at bedtime, or as directed by clinician. (See Oral, Topical Use Only under Dosage and Administration.)
Prescribing Limits
Pediatric Patients
Cerumen Removal OticChildren ≥12 years of age (6.5% otic solution): Maximum 4 consecutive days for self-medication.
Oral Irritation and Inflammation Oral TopicalChildren ≥2 years of age (10% oral topical solution): Maximum 7 days for self-medication.
Adults
Cerumen Removal Otic6.5% otic solution: Maximum 4 consecutive days for self-medication.
Oral Irritation and Inflammation Oral Topical10% oral topical solution: Maximum 7 days for self-medication.
Special Populations
No special population dosage recommendations.
Warnings
Warnings/Precautions
Otic Use
Do not use otic solution in patients allergic to the preparation.
Not for self-medication if patient has ear drainage or discharge, ear pain, irritation or rash in ear, dizziness, ear injury, eardrum perforation, or has had ear surgery.
Self-medication: Do not use for >4 consecutive days, unless otherwise directed by clinician.
Discontinue use and contact clinician if excessive earwax remains after using otic solution for 4 consecutive days.
Oral Topical Use
Discontinue use and contact clinician (dentist or physician) if swelling, rash, or fever develops or if irritation, pain, or redness in mouth persists or worsens.
Self-medication: Do not use for >7 days, unless otherwise directed by clinician. Discontinue use and contact clinician if sore mouth symptoms do not improve after 7 days of treatment.
Specific Populations
PregnancyOtic solution: At least one manufacturer states that pregnant women should consult clinician before using for self-medication.
LactationOtic solution: At least one manufacturer states that women who are breast-feeding should consult clinician before using for self-medication.
Pediatric UseOtic solution: Do not use in children <12 years of age, unless otherwise directed by clinician.
Oral topical solution: Do not use in children <2 years of age, unless otherwise directed by clinician. Use in children 2–12 years of age only if supervised by an adult.
Common Adverse Effects
Otic solution: Ear pruritus.
What other drugs will affect Carbamide Peroxide
No formal drug interaction studies.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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