Carboprost
Generic name: Carboprost
Brand names: Hemabate
Dosage form: injectable solution (250 mcg/mL)
Drug class:
Uterotonic agents
Usage of Carboprost
Carboprost is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions.
Carboprost is used to treat severe bleeding after childbirth (postpartum).
Carboprost is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons. Carboprost is often used when another method of abortion has not completely emptied the uterus, or when a complication of pregnancy would cause the baby to be born too early to survive.
Carboprost may also be used for purposes not listed in this medication guide.
Carboprost side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Carboprost may cause serious side effects. Call your doctor at once if you have:
Common side effects of carboprost may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Carboprost
You should not receive carboprost if you are allergic to it, or if you have:
To make sure carboprost is safe for you, tell your doctor if you have:
It is not known whether carboprost passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Relate drugs
- Carboprost
- Cervidil
- Dinoprostone
- Dinoprostone topical
- Hemabate
- Methergine (Methylergonovine Injection)
- Methergine (Methylergonovine Oral)
- Methergine oral and injection
- Methylergonovine (Injection)
- Methylergonovine (Oral)
- Methylergonovine oral and injection
- Oxytocin
- Pitocin
- Prepidil
- Prostin E2
How to use Carboprost
Usual Adult Dose for Abortion:
Initial dose: 250 mcg (1 mL) once by deep IM injection, with a tuberculin syringeSubsequent doses of 250 mcg (1 mL) may be administered at 1.5 to 3.5 hour intervals Depending on uterine response.An optional test dose of 100 mcg (0.4 mL) may be administered initially. The dose may be increased to 500 mcg (2 mL) if uterine contractility is judged to be inadequate after several doses of 250 mcg (1 mL).Maximum total dose: 12 mgDuration of therapy: No more than 2 continuous daysUses:-Aborting pregnancy between the 13 th and 20 th weeks of gestation (calculated from the first day of the last normal menstrual period)-Failure of expulsion of the fetus during the course of treatment by another method-Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity-Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus-Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion
Usual Adult Dose for Postpartum Bleeding:
Initial dose: 250 mcg (1 mL) once by deep IM injectionAdditional doses can be administered at intervals of 15 to 90 minutes, if necessary.Maximum total dose: 2 mg (8 doses)Comments: The need for additional injections and the administration interval should be determined by the attending physician as dictated by the course of clinical events.Uses: Refractory postpartum hemorrhage due to uterine atony that has not responded to conventional methods of management.
Warnings
You should not receive carboprost if you have active pelvic inflammatory disease, a breathing disorder, heart disease, liver disease, or kidney disease.
This medicine in given in a hospital or clinic setting to quickly treat any serious side effects that occur.
What other drugs will affect Carboprost
Other drugs may interact with carboprost, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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