Cedazuridine and decitabine

Generic name: Cedazuridine And Decitabine
Brand names: Inqovi
Dosage form: oral tablet (100 mg-35 mg)
Drug class: Antineoplastic combinations

Usage of Cedazuridine and decitabine

Cedazuridine and decitabine is a combination medicine that is used to treat myelodysplastic syndromes (certain types of blood or bone marrow disorders).

Cedazuridine and decitabine may also be used for purposes not listed in this medication guide.

Cedazuridine and decitabine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cedazuridine and decitabine may cause serious side effects. Call your doctor at once if you have:

easy bruising, unusual bleeding, purple or red spots under your skin;

low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or

signs of a lung infection--fever, chills, cough with mucus, chest pain, feeling short of breath.

Your treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of cedazuridine and decitabine may include:

fever, low blood cell counts;

bruising or bleeding;

abnormal liver function tests;

headache, dizziness, feeling tired;

swelling in your arms or legs;

muscle or joint pain;

painful mouth sores;

shortness of breath, lung infection;

nausea, loss of appetite;

diarrhea, constipation;

rash; or

cold symptoms such as stuffy nose, sneezing, cough, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Cedazuridine and decitabine

Tell your doctor if you have ever had:

kidney disease; or

liver disease.

You may need to have a negative pregnancy test before starting this treatment.

Cedazuridine and decitabine can harm an unborn baby or cause birth defects if the mother or the father is using cedazuridine and decitabine.

If you are a woman, do not use cedazuridine and decitabine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

Cedazuridine and decitabine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while using cedazuridine and decitabine and for at least 2 weeks after your last dose.

Cedazuridine and decitabine is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Cedazuridine and decitabine

Usual Adult Dose for Myelodysplastic Syndrome:

1 tablet (containing 100 mg cedazuridine and 35 mg decitabine) orally once daily on Days 1 through 5 of each 28-day cycle for a minimum of 4 cycles until disease progression or unacceptable toxicity; a complete or partial response may take longer than 4 cyclesComments:-Consider administering antiemetics prior to each dose to minimize nausea and vomiting.Use: For myelodysplastic syndromes (MDS), including previously treated and untreated, de novo and secondary MDS with the following French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and chronic myelomonocytic leukemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups

Warnings

Cedazuridine and decitabine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.

What other drugs will affect Cedazuridine and decitabine

Other drugs may affect cedazuridine and decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.