Cefiderocol

Generic name: Cefiderocol
Brand names: Fetroja
Dosage form: intravenous powder for injection (1 g)
Drug class: Other cephalosporins

Usage of Cefiderocol

Cefiderocol is a cephalosporin (SEF-a-lo-SPOR-in) antibiotic that is used to treat serious bladder or kidney infections in adults.

Cefiderocol is also used to treat adults who have developed pneumonia while being in a hospital or using a ventilator.

Cefiderocol may also be used for purposes not listed in this medication guide.

Cefiderocol side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Cefiderocol may cause serious side effects. Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

tremor, rigid muscles, or a seizure;

white patches or sores inside your mouth or on your lips; or

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects of cefiderocol may include:

nausea, vomiting, diarrhea, constipation;

mouth sores;

cough;

abnormal liver function tests;

headache;

rash; or

pain, redness, itching, bruising, or swelling around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Cefiderocol

Cefiderocol can cause serious or life-threatening allergic reactions. You should not use cefiderocol if you have ever had a severe allergic reaction to an antibiotic, such as:

cefadroxil, cefdinir, Cefoxitin, Cefprozil, Ceftriaxone, Cefuroxime, Cephalexin, Keflex, Omnicef, and others;

avibactam, relebactam, sulbactam, tazobactam, vaborbactam, and others; or

amoxicillin (Amoxil, Augmentin, Moxatag), ampicillin, dicloxacillin, oxacillin, penicillin, and others.

Tell your doctor if you have ever had:

an allergy to any drug (especially penicillin);

kidney disease (or if you are on dialysis);

a seizure;

liver disease; or

intestinal problems, such as colitis.

Tell your doctor if you are pregnant or breastfeeding.

Relate drugs

How to use Cefiderocol

Usual Adult Dose for Pyelonephritis:

2 g IV every 8 hours for 7 to 14 daysComments:-Recommended for patients with CrCl 60 to 119 mL/minUse: Treatment of complicated urinary tract infections (including pyelonephritis) due to susceptible EscheriChia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex

Usual Adult Dose for Urinary Tract Infection:

2 g IV every 8 hours for 7 to 14 daysComments:-Recommended for patients with CrCl 60 to 119 mL/minUse: Treatment of complicated urinary tract infections (including pyelonephritis) due to susceptible Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex

Usual Adult Dose for Nosocomial Pneumonia:

2 g IV every 8 hours for 7 to 14 daysComments:-Recommended for patients with CrCl 60 to 119 mL/minUses: For the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia due to susceptible Acinetobacter baumannii complex, E coli, E cloacae complex, K pneumoniae, P aeruginosa, and Serratia marcescens

Warnings

Cefiderocol can cause serious or life-threatening allergic reactions. Tell your doctor if you have an allergy to an antibiotic, especially penicillin.

What other drugs will affect Cefiderocol

Other drugs may affect cefiderocol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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