Cefuroxime
Drug class: Antineoplastic Agents
Usage of Cefuroxime
Acute Otitis Media (AOM)
Treatment of AOM caused by Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or S. pyogenes.
When anti-infectives indicated, AAP recommends high-dose amoxicillin or amoxicillin and clavulanate as drugs of choice for initial treatment of AOM; certain cephalosporins (cefdinir, cefpodoxime, cefuroxime, ceftriaxone) recommended as alternatives for initial treatment in penicillin-allergic patients without a history of severe and/or recent penicillin-allergic reactions.
Pharyngitis and Tonsillitis
Treatment of pharyngitis and tonsillitis caused by S. pyogenes (group A β-hemolytic streptococci). Generally effective in eradicating S. pyogenes from nasopharynx; efficacy in prevention of subsequent rheumatic fever not established.
AAP, IDSA, AHA, and others recommend a penicillin regimen (10 days of oral penicillin V or oral amoxicillin or single dose of IM penicillin G benzathine) as treatments of choice for S. pyogenes pharyngitis and tonsillitis; other anti-infectives (oral cephalosporins, oral macrolides, oral clindamycin) recommended as alternatives in penicillin-allergic patients.
If an oral cephalosporin used, 10 day regimen of first generation cephalosporin (cefadroxil, Cephalexin) preferred instead of other cephalosporins with broader spectrums of activity (e.g., cefaclor, cefdinir, cefixime, cefpodoxime, cefuroxime).
Bone and Joint Infections
Parenteral treatment of bone and joint infections caused by susceptible Staphylococcus aureus (including penicillinase-producing strains).
Meningitis
Parenteral treatment of meningitis caused by susceptible S. pneumoniae, H. influenzae (including ampicillin-resistant strains), Neisseria meningitidis, or S. aureus (including penicillinase-producing strains).
Not a drug of choice for meningitis; treatment failures have been reported, especially in meningitis caused by H. influenzae. In addition, bacteriologic response to cefuroxime appears to be slower than that reported with ceftriaxone, which may increase the risk for hearing loss and neurologic sequelae. When a cephalosporin is indicated for the treatment of bacterial meningitis, a parenteral third generation cephalosporin (usually ceftriaxone or cefotaxime) generally recommended.
Respiratory Tract Infections
Treatment of acute maxillary sinusitis caused by susceptible S. pneumoniae or H. influenzae (non-β-lactamase-producing strains only). Data insufficient to date to establish efficacy for treatment of acute maxillary sinusitis known or suspected to be caused by β-lactamase-producing strains of H. influenzae or M. catarrhalis. Because of variable activity against S. pneumoniae and H. influenzae, IDSA no longer recommends second or third generation oral cephalosporins for empiric monotherapy of acute bacterial sinusitis. Oral amoxicillin or amoxicillin and clavulanate usually recommended for empiric treatment. If an oral cephalosporin used as an alternative in children (e.g., in penicillin-allergic individuals), combination regimen that includes a third generation cephalosporin (cefixime or cefpodoxime) and clindamycin (or linezolid) recommended.
Treatment of secondary bacterial infections of acute bronchitis caused by susceptible S. pneumoniae, H. influenzae (non-β-lactamase-producing strains only), or H. parainfluenzae (non-β-lactamase-producing strains only).
Treatment of acute exacerbations of chronic bronchitis caused by susceptible S. pneumoniae, H. influenzae (non-β-lactamase-producing strains only), or H. parainfluenzae (non-β-lactamase-producing strains only).
Parenteral treatment of lower respiratory tract infections (including pneumonia) caused by susceptible S. pneumoniae, S. aureus (including penicillinase-producing strains), S. pyogenes (group A β-hemolytic streptococci), H. influenzae (including ampicillin-resistant strains), EscheriChia coli, or Klebsiella.
Treatment of community-acquired pneumonia (CAP). Recommended by ATS and IDSA as an alternative for treatment of CAP caused by penicillin-susceptible S. pneumoniae. Also recommended as an alternative in certain combination regimens used for empiric treatment of CAP. Select regimen for empiric treatment of CAP based on most likely pathogens and local susceptibility patterns; after pathogen is identified, modify to provide more specific therapy (pathogen-directed therapy).
For empiric outpatient treatment of CAP when risk factors for drug-resistant S. pneumoniae are present (e.g., comorbidities such as chronic heart, lung, liver, or renal disease, diabetes, alcoholism, malignancies, asplenia, immunosuppression; use of anti-infectives within the last 3 months), ATS and IDSA recommend monotherapy with a fluoroquinolone active against S. pneumoniae (moxifloxacin, gemifloxacin, levofloxacin) or, alternatively, a combination regimen that includes a β-lactam active against S. pneumoniae (high-dose amoxicillin or fixed combination of amoxicillin and clavulanic acid or, alternatively, ceftriaxone, cefpodoxime, or cefuroxime) given in conjunction with a macrolide (azithromycin, clarithromycin, erythromycin) or doxycycline. Cefuroxime and cefpodoxime may be less active against S. pneumoniae than amoxicillin or ceftriaxone.
If a parenteral cephalosporin is used as an alternative to penicillin G or amoxicillin for treatment of CAP caused by penicillin-susceptible S. pneumoniae, ATS and IDSA recommend ceftriaxone, cefotaxime or cefuroxime; if an oral cephalosporin is used for treatment of these infections, ATS and IDSA recommend cefpodoxime, cefprozil, cefuroxime, cefdinir, or cefditoren.
Septicemia
Parenteral treatment of septicemia caused by susceptible S. aureus (including penicillinase-producing strains), S. pneumoniae, E. coli, H. influenzae (including ampicillin-resistant strains), or Klebsiella.
In the treatment of known or suspected sepsis or the treatment of other serious infections when the causative organism is unknown, concomitant therapy with an aminoglycoside may be indicated pending results of in vitro susceptibility tests.
Skin and Skin Structure Infections
Oral treatment of uncomplicated skin and skin structure infections caused by susceptible S. aureus (including β-lactamase-producing strains) or S. pyogenes.
Parenteral treatment of skin and skin structure infections caused by susceptible S. aureus (including β-lactamase-producing strains), S. pyogenes, E. coli, Klebsiella, or Enterobacter.
Urinary Tract Infections (UTIs)
Oral treatment of uncomplicated UTIs caused by susceptible E. coli or K. pneumoniae.
Parenteral treatment of UTIs caused by susceptible E. coli or K. pneumoniae.
Gonorrhea and Associated Infections
Has been used orally or parenterally for treatment of uncomplicated urethral, endocervical, or rectal gonorrhea caused by susceptible Neisseria gonorrhoeae.
Has been used parenterally for treatment of disseminated gonococcal infections caused by susceptible N. gonorrhoeae.
Not included in current CDC recommendations for gonococcal infections.
Because of concerns related to recent reports of N. gonorrhoeae with reduced susceptibility to cephalosporins, CDC states that oral cephalosporins no longer recommended as first-line treatment for uncomplicated gonorrhea. For treatment of uncomplicated urogenital, anorectal, or pharyngeal gonorrhea, CDC recommends a combination regimen that includes a single dose of IM ceftriaxone and either a single dose of oral azithromycin or 7-day regimen of oral doxycycline.
Lyme Disease
Treatment of early Lyme disease manifested as erythema migrans. IDSA, AAP, and other clinicians recommend oral doxycycline, oral amoxicillin, or oral cefuroxime axetil as first-line therapy for treatment of early localized or early disseminated Lyme disease associated with erythema migrans, in the absence of specific neurologic involvement or advanced atrioventricular (AV) heart block.
Treatment of early neurologic Lyme disease† [off-label] in patients with cranial nerve palsy alone without evidence of meningitis (i.e., those with normal CSF examinations or those for whom CSF examination is deemed unnecessary because there are no clinical signs of meningitis). Parenteral anti-infectives (IV ceftriaxone, IV penicillin G sodium, or IV cefotaxime) recommended for treatment of early Lyme disease when there are acute neurologic manifestations such as meningitis or radiculopathy.
Treatment of Lyme carditis† [off-label]. IDSA and others state that patients with AV heart block and/or myopericarditis associated with early Lyme disease may be treated with an oral regimen (doxycycline, amoxicillin, or cefuroxime axetil) or a parenteral regimen (IV ceftriaxone or, alternatively, IV cefotaxime or IV penicillin G sodium). A parenteral regimen usually recommended for initial treatment of hospitalized patients; an oral regimen can be used to complete therapy and for the treatment of outpatients.
Treatment of borrelial lymphocytoma† [off-label]. Although experience is limited, IDSA states that available data indicate that borrelial lymphocytoma may be treated with an oral regimen (doxycycline, amoxicillin, or cefuroxime axetil).
Treatment of uncomplicated Lyme arthritis† [off-label] without clinical evidence of neurologic disease. An oral regimen (doxycycline, amoxicillin, or cefuroxime axetil) can be used, but a parenteral regimen (IV ceftriaxone or, alternatively, IV cefotaxime or IV penicillin G sodium) should be used in those with Lyme arthritis and concomitant neurologic disease. Patients with persistent or recurrent joint swelling after a recommended oral regimen should receive retreatment with the oral regimen or a switch to a parenteral regimen. Some clinicians prefer retreatment with an oral regimen for those whose arthritis substantively improved but did not completely resolve; these clinicians reserve parenteral regimens for those patients whose arthritis failed to improve or worsened. Allow several months for joint inflammation to resolve after initial treatment before an additional course of anti-infectives is given.
Perioperative Prophylaxis
Perioperative prophylaxis in patients undergoing cardiac surgery; a drug of choice for cardiac procedures (e.g., coronary artery bypass, pacemaker or other cardiac device insertion, ventricular assist devices).
Perioperative prophylaxis in patients undergoing clean head and neck surgery involving placement of prosthesis (excluding tympanostomy); perioperative prophylaxis in conjunction with metronidazole in patients undergoing clean-contaminated cancer surgery of the head and neck or other clean-contaminated head and neck procedures (excluding tonsillectomy and functional endoscopic sinus procedures). A drug of choice.
Has been used for perioperative prophylaxis in patients undergoing noncardiac thoracic surgery, GI or biliary tract surgery, gynecologic or obstetric surgery (e.g., vaginal hysterectomy), orthopedic procedures, or heart transplantation. Other anti-infectives (e.g., cefazolin) usually preferred.
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How to use Cefuroxime
Administration
Administer cefuroxime axetil orally. Administer cefuroxime sodium by IV injection or infusion or deep IM injection.
IV route preferred in patients with septicemia or other severe or life-threatening infections or in patients with lowered resistance, particularly if shock is present.
Cefuroxime ADD-Vantage (TwistVial) vials, Duplex drug delivery system containing cefuroxime and Dextrose injection in separate chambers, and the commercially available premixed cefuroxime injection (frozen) should be used only for IV infusion.
Oral Administration
Oral suspension must be administered with food.
Tablets may be given orally without regard to meals, but administration with food maximizes bioavailability.
Children 3 months to 12 years of age unable to swallow tablets should receive the oral suspension. Although the tablets have been crushed and mixed with food (e.g., applesauce, ice cream), the crushed tablets have a strong, persistent taste and the manufacturers state that the drug should not be administered in this manner.
ReconstitutionReconstitute powder for oral suspension at the time of dispensing by adding the amount of water specified on the bottle to provide a suspension containing 125 or 250 mg of cefuroxime per 5 mL of suspension.
Tap the bottle to thoroughly loosen the powder; add the water in a single portion and shake vigorously. Shake suspension well just prior to each use and replace the cap securely after each opening.
IV Injection
ReconstitutionReconstitute vials containing 750 mg or 1.5 g of cefuroxime with 8 or 16 mL of sterile water for injection, respectively, to provide solutions containing approximately 90 mg/mL.
Rate of AdministrationInject appropriate dose of reconstituted solution directly into a vein over a period of 3–5 minutes or slowly into the tubing of a freely flowing compatible IV solution.
IV Infusion
Other IV solutions flowing through a common administration tubing or site should be discontinued while cefuroxime is being infused unless the solutions are known to be compatible and the flow rate is adequately controlled. If an aminoglycoside is administered concomitantly with cefuroxime, the drugs should be administered at separate sites.
Reconstitution and DilutionReconstitute 7.5-g pharmacy bulk vial according to the manufacturer’s directions and then further dilute in a compatible IV infusion solution.
Reconstitute ADD-Vantage (TwistVial) vials containing 750 mg or 1.5 g according to the manufacturer’s directions.
Reconstitute (activate) commercially available Duplex drug delivery system containing 750 mg or 1.5 g of crystalline cefuroxime and 50 mL of dextrose injection in separate chambers according to the manufacturer’s directions.
Thaw the commercially available premixed cefuroxime injection (frozen) at room temperature (25°C) or in a refrigerator (5°C); do not force thaw by immersion in a water bath or by exposure to microwave radiation. A precipitate may have formed in the frozen injection, but should dissolve with little or no agitation after reaching room temperature. Discard thawed injection if an insoluble precipitate is present or if container seals or outlet ports are not intact or leaks are found. Do not use in series connections with other plastic containers; such use could result in air embolism from residual air being drawn from the primary container before administration of fluid from the secondary container is complete.
Rate of AdministrationIntermittent IV infusions generally infused over 15–60 minutes.
IM Injection
Administer IM injections deeply into a large muscle mass such as the gluteus or lateral aspect of the thigh. Use aspiration to ensure needle is not in a blood vessel.
ReconstitutionPrepare IM injections by reconstituting vial containing 750 mg of cefuroxime with 3 mL of sterile water for injection to provide a suspension containing approximately 220 mg/mL.
Shake IM suspension gently prior to administration.
Dosage
Available as cefuroxime axetil or cefuroxime sodium ; dosage expressed in terms of cefuroxime.
Tablets and oral suspension are not bioequivalent and are not substitutable on a mg/mg basis.
Pediatric Patients
General Pediatric Dosage Neonates IV or IMNeonates ≤7 days of age: 50 mg/kg every 12 hours, regardless of weight.
Neonates 8–28 days of age: 50 mg/kg every 8–12 hours for those weighing ≤2 kg or 50 mg/kg every 8 hours for those weighing >2 kg.
Mild to Moderate Infections OralChildren beyond neonatal period: AAP recommends 20–30 mg/kg daily given in 2 divided doses.
IV or IMChildren beyond neonatal period: AAP recommends 75–100 mg/kg daily given in 3 divided doses.
Children ≥3 months of age: Manufacturer states 50–100 mg/kg daily given in 3 or 4 equally divided doses has been effective for most infections in children .
Severe Infections OralOral route inappropriate for severe infections per AAP.
IV or IMChildren beyond neonatal period: AAP recommends 100–200 mg/kg daily given in 3 or 4 divided doses.
Children ≥3 months of age: Manufacturer recommends 100 mg/kg daily given in 3 or 4 equally divided doses.
Acute Otitis Media (AOM) Children 3 Months to 12 Years of Age OralTablets (for children able to swallow tablets whole): 250 mg twice daily for 10 days.
Oral suspension: 30 mg/kg daily (maximum 1 g daily) given in 2 divided doses for 10 days.
Has been given in a 5-day regimen† [off-label]. AAP does not recommend oral anti-infective regimens of <10 days’ duration in children <2 years of age or in patients with severe symptoms.
Pharyngitis and Tonsillitis Children 3 Months to 12 Years of Age OralOral suspension: 20 mg/kg daily (maximum 500 mg daily) in 2 divided doses for 10 days.
Adolescents ≥13 Years of Age OralTablets: 250 mg twice daily for 10 days.
Bone and Joint Infections Children 3 Months to 12 Years of Age IV or IM150 mg/kg daily given in equally divided doses every 8 hours.
Meningitis Children 3 Months to 12 Years of Age IV or IM200–240 mg/kg daily given in equally divided doses every 6–8 hours.
Respiratory Tract Infections Acute Sinusitis in Children 3 Months to 12 Years of Age OralTablets (for children able to swallow tablets whole): 250 mg twice daily for 10 days.
Oral suspension: 30 mg/kg daily (maximum 1 g daily) given in 2 divided doses for 10 days.
Acute Sinusitis in Adolescents ≥13 Years of Age OralTablets: 250 mg twice daily for 10 days.
Secondary Bacterial Infections of Acute Bronchitis in Adolescents ≥13 Years of Age OralTablets: 250 or 500 mg twice daily for 5–10 days.
Acute Exacerbations of Chronic Bronchitis in Adolescents ≥13 Years of Age OralTablets: 250 or 500 mg twice daily for 10 days. Efficacy of regimens <10 days has not been established.
Skin and Skin Structure Infections Impetigo in Children 3 Months to 12 Years of Age OralOral suspension: 30 mg/kg daily (maximum 1 g daily) in 2 divided doses for 10 days.
Uncomplicated Infections in Adolescents ≥13 Years of Age OralTablets: 250 or 500 mg twice daily for 10 days.
Urinary Tract Infections (UTIs) Uncomplicated Infections in Adolescents ≥13 Years of Age OralTablets: 250 mg twice daily for 7–10 days.
Gonorrhea and Associated Infections Uncomplicated Urethral, Cervical, or Rectal Gonorrhea In Adolescents ≥13 Years of Age OralTablets: 1 g as a single dose recommended by manufacturer.
Not recommended by CDC as first-line treatment. (See Gonorrhea and Associated Infections under Uses.)
Lyme Disease Early Localized or Early Disseminated Lyme Disease Manifested as Erythema Migrans OralTablets: 500 mg twice daily for 20 days in adolescents ≥13 years of age.
AAP, IDSA, and others recommend 30 mg/kg (maximum 500 mg) administered in 2 divided doses for 14 days (range 14–21 days) in children without specific neurologic involvement or advanced AV heart block.
Early Neurologic Lyme Disease† Oral30 mg/kg daily in 2 equally divided doses (up to 500 mg per dose) for 14 days (range 14–21 days) recommended by IDSA for children with cranial nerve palsy alone without clinical evidence of meningitis.
Lyme Carditis† Oral30 mg/kg daily in 2 equally divided doses (up to 500 mg per dose) for 14 days (range 14–21 days) recommended by IDSA.
Borrelial Lymphocytoma† Oral30 mg/kg daily in 2 equally divided doses (up to 500 mg per dose) for 14 days (range 14–21 days) recommended by IDSA.
Lyme Arthritis† Oral30 mg/kg daily in 2 equally divided doses (up to 500 mg per dose) for 28 days recommended by IDSA for children with uncomplicated Lyme arthritis without clinical evidence of neurologic disease.
Perioperative Prophylaxis Cardiac, Cardiothoracic, or Noncardiac Thoracic Surgery IV50 mg/kg given within 1 hour prior to incision. If procedure is prolonged (>4 hours) or if major blood loss occurs, additional 50-mg/kg doses may be given. No evidence of benefit beyond 48 hours and no evidence to support continuing prophylaxis until all drains and indwelling catheters are removed.
Adults
General Adult Dosage IV or IM750–1.5 g every 8 hours for 5–10 days.
Life-threatening Infections or Those Caused by Less Susceptible Organisms IV or IM1.5 g every 6 hours.
Pharyngitis and Tonsillitis OralTablets: 250 mg twice daily for 10 days.
Bone and Joint Infections IV or IM1.5 g every 8 hours.
Meningitis IV or IMUp to 3 g every 8 hours.
Respiratory Tract Infections Acute Sinusitis OralTablets: 250 mg twice daily for 10 days.
Secondary Bacterial Infections of Acute Bronchitis OralTablets: 250 or 500 mg twice daily for 5–10 days.
Acute Exacerbations of Chronic Bronchitis OralTablets: 250 or 500 mg twice daily for 10 days. Efficacy of regimens <10 days has not been established.
Pneumonia Oral500 mg twice daily recommended by ATS and IDSA for empiric treatment of community-acquired pneumonia† (CAP). Must be used in conjunction with other anti-infectives for empiric treatment of CAP. (See Respiratory Tract Infections under Uses.)
IV or IM750 mg every 8 hours. For severe or complicated infections, 1.5 g every 8 hours.
Skin and Skin Structure Infections Uncomplicated Infections OralTablets: 250 or 500 mg twice daily for 10 days.
IV or IM750 mg every 8 hours.
Severe or Complicated Infections IV or IM1.5 g every 8 hours.
Urinary Tract Infections (UTIs) Uncomplicated Infections OralTablets: 250 mg twice daily for 7–10 days.
IV or IM750 mg every 8 hours.
Severe or Complicated Infections IV or IM1.5 g every 8 hours.
Gonorrhea and Associated Infections Uncomplicated Urethral, Cervical, or Rectal Gonorrhea OralTablets: 1 g as a single dose has been used.
Not recommended by CDC as first-line treatment. (See Gonorrhea and Associated Infections under Uses.)
IM1.5 g as a single dose recommended by manufacturer; divide the dose, give at 2 different sites. Given in conjunction with 1 g of oral probenecid.
Not included in CDC recommendations. (See Uncomplicated Gonorrhea under Uses: Gonorrhea and Associated Infections.)
Disseminated Gonococcal Infections IV or IM750 mg every 8 hours recommended by manufacturer.
Not included in CDC recommendations. (See Gonorrhea and Associated Infections under Uses.)
Lyme Disease Early Localized or Early Disseminated Lyme Disease Manifested as Erythema Migrans OralTablets: 500 mg twice daily for 20 days.
IDSA and others recommend 500 mg twice daily for 14 days (range 14–21 days) in adults without specific neurologic involvement or advanced AV heart block.
Early Neurologic Lyme Disease† Oral500 mg twice daily for 14 days (range 14–21 days) recommended by IDSA for adults with cranial nerve palsy alone without clinical evidence of meningitis.
Lyme Carditis† Oral500 mg twice daily for 14 days (range 14–21 days) recommended by IDSA.
Borrelial Lymphocytoma† Oral500 mg twice daily for 14 days (range 14–21 days) recommended by IDSA.
Lyme Arthritis† Oral500 mg twice daily for 28 days recommended by IDSA for adults with uncomplicated Lyme arthritis without clinical evidence of neurologic disease.
Perioperative Prophylaxis Cardiac Surgery IVFor open-heart surgery, manufacturers recommend 1.5 g given at the time of induction of anesthesia and 1.5 g every 12 hours thereafter for a total dosage of 6 g.
For cardiac procedures, some experts recommend 1.5 g given within 1 hour prior to surgical incision and additional 1.5-g doses every 4 hours during prolonged procedures (>4 hours) or if major blood loss occurs.
Various data support a duration of perioperative prophylaxis ranging from a single preoperative dose to continuation for 24 hours postoperatively; no evidence of benefit beyond 48 hours and no evidence to support continuing prophylaxis until all drains and indwelling catheters are removed.
Other Surgery IV or IMManufacturer recommends 1.5 g given IV just prior to surgery (approximately 0.5–1 hour prior to initial incision) and, in lengthy operations, 750 mg given IV or IM every 8 hours. Postoperative doses usually unnecessary and may increase risk of bacterial resistance.
Some experts recommend 1.5 g given within 1 hour prior to surgical incision and additional 1.5-g doses every 4 hours during prolonged procedures (>4 hours) or if major blood loss occurs.
Special Populations
Renal Impairment
Dosage adjustments of parenteral cefuroxime necessary in patients with Clcr ≤20 mL/minute.
Adults with impaired renal function: 750 mg IM or IV every 12 hours in those with Clcr 10–20 mL/minute or 750 mg IM or IV every 24 hours in those with Clcr <10 mL/minute.
Patients undergoing hemodialysis: Give a supplemental dose of parenteral cefuroxime after each dialysis period.
Children with impaired renal function: Make adjustments to dosing frequency for IM or IV cefuroxime similar to those recommended for adults with renal impairment.
Safety and efficacy of oral cefuroxime in patients with renal impairment not established.
Geriatric Patients
Cautious dosage selection because of age-related decreases in renal function. (See Renal Impairment under Dosage and Administration.)
Warnings
Contraindications
Warnings/Precautions
Warnings
Superinfection/Clostridium difficile-associated Diarrhea and Colitis (CDAD)Possible emergence and overgrowth of nonsusceptible organisms with prolonged therapy. Careful observation of the patient is essential. Institute appropriate therapy if superinfection occurs.
Treatment with anti-infectives alters normal colon flora and may permit overgrowth of Clostridium difficile. C. difficile infection (CDI) and C. difficile-associated diarrhea and colitis (CDAD; also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) reported with nearly all anti-infectives, including cefuroxime, and may range in severity from mild diarrhea to fatal colitis. C. difficile produces toxins A and B which contribute to development of CDAD; hypertoxin-producing strains of C. difficile are associated with increased morbidity and mortality since they may be refractory to anti-infectives and colectomy may be required.
Consider CDAD if diarrhea develops during or after therapy and manage accordingly. Obtain careful medical history since CDAD may occur as late as 2 months or longer after anti-infective therapy is discontinued.
If CDAD is suspected or confirmed, discontinue anti-infectives not directed against C. difficile whenever possible. Initiate appropriate supportive therapy (e.g., fluid and electrolyte management, protein supplementation), anti-infective therapy directed against C. difficile (e.g., metronidazole, vancomycin), and surgical evaluation as clinically indicated.
Sensitivity Reactions
Hypersensitivity ReactionsPossible hypersensitivity reactions, including rash (maculopapular or erythematous), pruritus, fever, eosinophilia, urticaria, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
If an allergic reaction occurs, discontinue and institute appropriate therapy as indicated (e.g., epinephrine, corticosteroids, maintenance of an adequate airway and oxygen).
Cross-hypersensitivityPartial cross-sensitivity among cephalosporins and other β-lactam antibiotics, including penicillins and cephamycins.
Prior to initiation of therapy, make careful inquiry concerning previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs. Cautious use recommended in individuals hypersensitive to penicillins: avoid use in those who have had an immediate-type (anaphylactic) hypersensitivity reaction and administer with caution in those who have had a delayed-type (e.g., rash, fever, eosinophilia) reaction.
General Precautions
History of GI DiseaseUsed with caution in patients with a history of GI disease, particularly colitis. (See Superinfection/Clostridium difficile-associated Diarrhea and Colitis under Cautions.)
Prolonged PTProlonged PT reported with some cephalosporins.
Monitor PT in patients at risk, including those with renal or hepatic impairment, poor nutritional state, receiving prolonged therapy, or stabilized on anticoagulant therapy. Administer vitamin K when indicated.
Renal EffectsPeriodically evaluate renal status during therapy, especially in seriously ill patients receiving maximum dosage.
Caution if used concomitantly with nephrotoxic drugs (e.g., aminoglycosides, potent diuretics). (See Interactions.)
Selection and Use of Anti-infectivesTo reduce development of drug-resistant bacteria and maintain effectiveness of cefuroxime and other antibacterials, use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria.
When selecting or modifying anti-infective therapy, use results of culture and in vitro susceptibility testing. In the absence of such data, consider local epidemiology and susceptibility patterns when selecting anti-infectives for empiric therapy.
Patients with MeningitisMild to moderate hearing loss reported rarely in pediatric patients who received cefuroxime for treatment of meningitis.
Persistence of positive CSF cultures at 18–36 hours reported; clinical importance unknown.
PhenylketonuriaCeftin oral suspensions containing 125 or 250 mg of cefuroxime/5 mL contain aspartame (NutraSweet), which is metabolized in the GI tract to provide 11.8 or 25.2 mg of phenylalanine/5 mL, respectively.
Sodium ContentCefuroxime sodium contains approximately 54.2 mg (2.4 mEq) of sodium per g of cefuroxime.
Specific Populations
PregnancyCategory B.
LactationDistributed into milk; use with caution.
Pediatric UseSafety and efficacy of oral or parenteral cefuroxime not established in children <3 months of age. Other cephalosporins accumulate in neonates resulting in prolonged serum half-life.
Safety and efficacy of oral cefuroxime for treatment of acute bacterial maxillary sinusitis in pediatric patients 3 months to 12 years of age have been established based on safety and efficacy of the drug in adults. In addition, use of oral cefuroxime in pediatric patients is supported by pharmacokinetic and safety data in adult and pediatric patients, clinical and microbiologic data from adequate and well-controlled studies of the treatment of acute bacterial maxillary sinusitis in adults and acute otitis media with effusion in pediatric patients, and postmarketing surveillance of adverse effects.
Tablets should not be crushed for pediatric administration since the drug has a strong, persistent, bitter taste; vomiting was induced aversively in some children who received crushed tablets. The oral suspension should be used in children who cannot swallow tablets whole.
To avoid overdosage, the commercially available Duplex drug delivery system containing 750 mg or 1.5 g of cefuroxime and 50 mL of dextrose injection in separate chambers should not be used in pediatric patients unless the entire 750-mg or 1.5-g dose is required.
Geriatric UseNo overall differences in safety and efficacy in those ≥65 years of age compared with younger adults, but the possibility of increased sensitivity in some geriatric individuals cannot be ruled out.
Substantially eliminated by kidneys; risk of toxicity may be greater in those with impaired renal function. Select dosage with caution; renal function monitoring may be useful because of age-related decreases in renal function. (See Renal Impairment under Dosage and Administration.)
Renal ImpairmentPossible decreased clearance and increased serum half-life.
Dosage adjustments of parenteral cefuroxime necessary in patients with Clcr ≤20 mL/minute. (See Renal Impairment under Dosage and Administration.)
Safety and efficacy of oral cefuroxime in patients with renal impairment not established.
Common Adverse Effects
GI effects (nausea, vomiting, diarrhea/loose stools), hypersensitivity reactions, local reactions at IV injection sites.
What other drugs will affect Cefuroxime
Specific Drugs and Laboratory Tests
Drug or Test
Interaction
Comments
Aminoglycosides
Nephrotoxicity reported with concomitant use of some cephalosporins and aminoglycosides
In vitro evidence of additive or synergistic antibacterial activity against some Enterobacteriaceae
Administer separately; do not admix
Diuretics
Possible increased risk of nephrotoxicity if used concomitantly with potent diuretics
Use concomitantly with caution
Estrogens or progestins
May affect gut flora, leading to decreased estrogen reabsorption and reduced efficacy of oral contraceptives containing estrogen and progestin
Probenecid
Decreased clearance and increased serum concentrations and half-life of cefuroxime
Tests for glucose
Possible false-positive reactions in urine glucose tests using Clinitest, Benedict’s solution, or Fehling’s solution
Use glucose tests based on enzymatic glucose oxidase reactions (e.g., Clinistix, Tes-Tape)
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