Centruroides Immune F(ab′)2
Brand names: Anascorp
Drug class:
Antineoplastic Agents
Usage of Centruroides Immune F(ab′)2
Scorpion Envenomation
Treatment of clinical signs of scorpion envenomation; designated an orphan drug by FDA for this use.
May shorten time to resolution of envenomation symptoms, possibly eliminating need for treatment in an intensive care unit.
In the US, Centruroides sculpturatus (commonly known as the bark scorpion) is the only scorpion considered potentially dangerous to humans; found mainly in Arizona, but may be found in parts of California, New Mexico, Texas, Nevada, and northern Mexico.
Consider consultation with experts experienced in treating Centruroides envenomation (e.g., Arizona Poison and Drug Information Center in Tucson, Banner Good Samaritan Poison and Drug Information Center in Phoenix).
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How to use Centruroides Immune F(ab′)2
General
Administration
IV Administration
Administer by IV infusion.
Reconstitution and DilutionReconstitute each vial of lyophilized Centruroides (scorpion) immune F(ab′)2 (equine) with 5 mL of 0.9% sodium chloride; mix using continuous gentle swirling. When multiple vials are indicated (e.g., for initial dose), combine required number of reconstituted vials immediately following reconstitution.
Prior to infusion, dilute total dose (total combined reconstituted vials) to a total volume of 50 mL using 0.9% sodium chloride.
Rate of AdministrationAdminister by IV infusion over 10 minutes.
Dosage
Dosage expressed in terms of number of vials.
Pediatric Patients
Scorpion Envenomation IVInitially, 3 vials.
Give additional 1-vial doses every 30–60 minutes as needed.
Adults
Scorpion Envenomation IVInitially, 3 vials.
Give additional 1-vial doses every 30–60 minutes as needed.
Special Populations
No special population dosage recommendations.
Warnings
Contraindications
Warnings/Precautions
Sensitivity Reactions
Hypersensitivity Reactions.Severe hypersensitivity reactions, including anaphylaxis, may occur.
Patients with known allergies to equine protein are at increased risk for anaphylactic reactions. Patients who previously received Centruroides (scorpion) immune F(ab′)2 (equine) or another equine antivenom or antitoxin may be at increased risk for severe hypersensitivity reactions.
Monitor closely for hypersensitivity during antivenom infusion; IV epinephrine, corticosteroids, and diphenhydramine should be readily available.
If anaphylactic reaction occurs, immediately discontinue antivenom infusion and initiate appropriate emergency medical care.
Delayed Hypersensitivity or Serum Sickness Reactions.Delayed hypersensitivity or serum sickness reactions may occur. Mild symptoms may include pruritus, nausea, urticaria, low-grade fever, and malaise; severe manifestations include persistent urticaria, vomiting, arthralgia, myalgia, syncope, and angioedema.
Monitor for manifestations of delayed allergic reactions or serum sickness (e.g., rash, fever, myalgia, arthralgia) at follow-up visits. Treat such reactions as necessary; treatment is generally symptomatic (e.g., antihistamines, analgesics, antipyretics, corticosteroids).
Risk of Transmissible Infectious Agents
Prepared from equine plasma; potentially may transmit infectious agents, including viruses. Several steps in manufacturing process (e.g., pepsin digestion, ammonium sulfate precipitation/heat treatment, nanofiltration) reduce risk of transmission of viruses.
Cresol Content
Contains trace amounts of cresol (<0.41 mg per vial) from manufacturing process. Cresol used as an injectable excipient has resulted in localized reactions and generalized myalgia.
Specific Populations
PregnancyCategory C.
LactationNot known whether distributed into milk. Use with caution in nursing women.
Pediatric UseEfficacy and safety in pediatric patients comparable to that in adults. Has been used in children ranging from younger than 1 month to 18 years of age.
Geriatric UseEfficacy and safety in geriatric patients not studied specifically; considered comparable to that in overall patient population.
Common Adverse Effects
Vomiting, pyrexia, rash, nausea, pruritus.
What other drugs will affect Centruroides Immune F(ab′)2
No formal drug interaction studies to date.
Disclaimer
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