Cetirizine (EENT)
Brand names: Zerviate
Drug class:
Antineoplastic Agents
Usage of Cetirizine (EENT)
Cetirizine hydrochloride has the following uses:
Cetirizine hydrochloride ophthalmic solution (cetirizine 0.24%) is indicated for treatment of ocular itching associated with allergic conjunctivitis.
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How to use Cetirizine (EENT)
General
Cetirizine hydrochloride is available in the following dosage form(s) and strength(s):
Sterile ophthalmic solution: 2.4 mg of cetirizine per mL (0.24%).
Dosage
It is essential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Pediatric Patients
The recommended dosage of cetirizine hydrochloride ophthalmic solution (cetirizine 0.24%) is one drop instilled in each affected eye twice daily (approximately 8 hours apart).
Adults
The recommended dosage of cetirizine hydrochloride ophthalmic solution (cetirizine 0.24%) is one drop instilled in each affected eye twice daily (approximately 8 hours apart).
Warnings
Contraindications
None.
Warnings/Precautions
Contamination of Tip and Solution
As with any eye drop, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle to prevent contaminating the tip and solution. Keep the bottle closed when not in use.
Contact Lens Wear
Patients should be advised not to wear a contact lens if their eye is red.
Cetirizine hydrochloride should not be instilled while wearing contact lenses. Remove contact lenses prior to instillation of cetirizine hydrochloride. The preservative in cetirizine hydrochloride, benzalkonium chloride, may be absorbed by soft contact lenses. Lenses may be reinserted after 10 minutes following administration of cetirizine hydrochloride.
Specific Populations
PregnancyRisk Summary: There were no adequate or well-controlled studies with cetirizine hydrochloride ophthalmic solution (cetirizine 0.24%) in pregnant women. Cetirizine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Animal Data: Cetirizine was not teratogenic in mice, rats, or rabbits at oral doses up to 96, 225, and 135 mg/kg, respectively (approximately 1300, 4930, and 7400 times the maximum recommended human ophthalmic dose, on a mg/m 2 basis).
LactationCetirizine has been reported to be excreted in human breast milk following oral administration. Multiple doses of oral cetirizine (10 mg tablets once daily for 10 days) resulted in systemic levels (mean C max= 311 ng/mL) that were 100 times higher than the observed human exposure (mean C max= 3.1 ng/mL) following twice-daily administration of Cetirizine ophthalmic solution 0.24% to both eyes for one week. Comparable bioavailability has been found between the tablet and syrup dosage forms. However, it is not known whether the systemic absorption resulting from topical ocular administration of cetirizine hydrochloride could produce detectable quantities in human breast milk.
There is no adequate information regarding the effects of cetirizine on breastfed infants, or the effects on milk production to inform risk of cetirizine hydrochloride to an infant during lactation. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for cetirizine hydrochloride and any potential adverse effects on the breastfed child from cetirizine hydrochloride.
Pediatric UseThe safety and effectiveness of cetirizine hydrochloride has been established in pediatric patients two years of age and older. Use of cetirizine hydrochloride in these pediatric patients is supported by evidence from adequate and well-controlled studies of cetirizine hydrochloride in pediatric and adult patients.
Geriatric UseNo overall differences in safety or effectiveness have been observed between elderly and younger patients.
Common Adverse Effects
The most common adverse reactions (1–7%) were ocular hyperemia, instillation site pain, and visual acuity reduced.
What other drugs will affect Cetirizine (EENT)
Specific Drugs
It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:
Please see product labeling for drug interaction information.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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