Chlorpheniramine, ibuprofen, and phenylephrine

Generic name: Chlorpheniramine, Ibuprofen, And Phenylephrine
Drug class: Upper respiratory combinations

Usage of Chlorpheniramine, ibuprofen, and phenylephrine

Chlorpheniramine, ibuprofen, and phenylephrine combination is used to relieve symptoms of allergies and cold, including fever, headache, itching of the nose and throat, itchy, watery eyes, minor aches and pains, sneezing, or runny or stuffy nose. It also helps reduce swelling of the nasal passages and restores easier breathing through the nose.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain.

This medicine is available as an over-the-counter (OTC) product.

Chlorpheniramine, ibuprofen, and phenylephrine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Bloody or black, tarry stools

chest pain or tightness

confusion

constipation

cough

decrease urine output

diarrhea

difficulty in speaking

difficulty swallowing

dilated neck veins

dizziness

double vision

fast heartbeat

headache

heartburn

hives, itching, skin rash

inability to speak

inability to move the arms, legs, or facial muscles

indigestion

irregular breathing

nausea

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe stomach pain, cramping, or burning

swelling of the face, fingers, feet, or lower legs

trouble breathing

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Nervousness

trouble sleeping

unusual excitement, especially in children

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Chlorpheniramine, ibuprofen, and phenylephrine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of chlorpheniramine, ibuprofen, and phenylephrine combination in children 12 years of age and older. This medicine should not be used in children younger than 12 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlorpheniramine, ibuprofen, and phenylephrine combination in the elderly. However, elderly patients more likely to develop age-related stomach problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

ChlorpheniraminePhenylephrine

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Ibuprofen

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Dihydroergotamine

Ketorolac

Linezolid

Potassium Citrate

Rasagiline

Selegiline

Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

ABCiximab

Aceclofenac

Acemetacin

Acenocoumarol

Alfentanil

Almotriptan

Amantadine

Amifampridine

Amiloride

Amineptine

Amitriptyline

Amitriptylinoxide

Amoxapine

Amphetamine

Amtolmetin Guacil

Anagrelide

Apixaban

Ardeparin

Argatroban

Aspirin

Balsalazide

Bemetizide

Bemiparin

Bendroflumethiazide

Benzhydrocodone

Benzphetamine

Benzthiazide

Betamethasone

Betrixaban

Bismuth Subsalicylate

Bivalirudin

Bromfenac

Budesonide

Bufexamac

Bumetanide

Buprenorphine

Bupropion

Butorphanol

Cangrelor

Celecoxib

Certoparin

Chlorothiazide

Chlorthalidone

Choline Magnesium Trisalicylate

Choline Salicylate

Cilostazol

Citalopram

Clomipramine

Clonixin

Clopamide

Clopidogrel

Clozapine

Codeine

Cortisone

Cyclopenthiazide

Cyclosporine

Cyclothiazide

Dabigatran Etexilate

Dalteparin

Danaparoid

Deflazacort

Desipramine

Desirudin

Desmopressin

Desvenlafaxine

Dexamethasone

Dexibuprofen

Dexketoprofen

Dextroamphetamine

Dextromethorphan

Diazoxide

Dibenzepin

Diclofenac

Diflunisal

Digoxin

Dihydrocodeine

Dipyridamole

Dipyrone

Dolasetron

Donepezil

Dothiepin

Doxepin

Droxicam

Duloxetine

Edoxaban

Emtricitabine

Enoxaparin

Eplerenone

Epoprostenol

Eptifibatide

Ergonovine

Escitalopram

Ethacrynic Acid

Etodolac

Etofenamate

Etoricoxib

Etozolin

Felbinac

Fenfluramine

Fenoprofen

Fentanyl

Fepradinol

Feprazone

Feverfew

Floctafenine

Fluconazole

Flufenamic Acid

Fluocortolone

Fluoxetine

Flurbiprofen

Fluvoxamine

Fondaparinux

Fosphenytoin

Furosemide

Gepirone

Ginkgo

Glucagon

Glycopyrrolate

Glycopyrronium Tosylate

Gossypol

Granisetron

Heparin

Hydrochlorothiazide

Hydrocodone

Hydrocortisone

Hydroflumethiazide

Hydromorphone

Hydroxyamphetamine

Hydroxytryptophan

Iloprost

Imipramine

Indapamide

Indomethacin

Inotersen

Iobenguane I 123

Iobenguane I 131

Ketoprofen

Lasmiditan

Lepirudin

Levomilnacipran

Levorphanol

Lisdexamfetamine

Lithium

Lofepramine

Lorcaserin

Lornoxicam

Loxoprofen

Lumacaftor

Lumiracoxib

Mavacamten

Meadowsweet

Meclofenamate

Mefenamic Acid

Melitracen

Meloxicam

Melphalan

Meperidine

Mesalamine

Metaxalone

Methacholine

Methadone

Methamphetamine

Methotrexate

Methyclothiazide

Methylene Blue

Methylergonovine

Methylprednisolone

Metolazone

Midodrine

Milnacipran

Mirtazapine

Morniflumate

Morphine

Morphine Sulfate Liposome

Nabumetone

Nadroparin

Nalbuphine

Naproxen

Nefazodone

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Nortriptyline

Olsalazine Sodium

Ondansetron

Opipramol

Oxaprozin

Oxycodone

Oxymorphone

Oxyphenbutazone

Palonosetron

Paramethasone

Parecoxib

Parnaparin

Paroxetine

Pemetrexed

Pentazocine

Pentosan Polysulfate Sodium

Pentoxifylline

Phenindione

Phenprocoumon

Phenylbutazone

Phenytoin

Piketoprofen

Piretanide

Piroxicam

Pitolisant

Polythiazide

Potassium Citrate

Pranoprofen

Prasugrel

Prednisolone

Prednisone

Proglumetacin

Propyphenazone

Proquazone

Protein C

Protriptyline

Quetiapine

Quinethazone

Remifentanil

Revefenacin

Reviparin

Rivaroxaban

Rofecoxib

Salicylic Acid

Salsalate

Scopolamine

Secretin Human

Selexipag

Sertraline

Sibutramine

Sodium Salicylate

Spironolactone

Sufentanil

Sulfasalazine

Sulfinpyrazone

Sulindac

Sulodexide

Tacrolimus

Tapentadol

Tenofovir Alafenamide

Tenofovir Disoproxil Fumarate

Tenoxicam

Tianeptine

Tiaprofenic Acid

Ticagrelor

Ticlopidine

Tinzaparin

Tiotropium

Tirofiban

Tocilizumab

Tolfenamic Acid

Tolmetin

Torsemide

Tramadol

Trazodone

Treprostinil

Triamterene

Trichlormethiazide

Trimipramine

Valdecoxib

Venlafaxine

Vilazodone

Vorapaxar

Vortioxetine

Warfarin

Xipamide

Zavegepant

Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Amikacin

Atenolol

Azilsartan

Azilsartan Medoxomil

Benazepril

Betaxolol

Bisoprolol

Candesartan

Captopril

Carteolol

Carvedilol

Celiprolol

Enalapril

Enalaprilat

Eprosartan

Esmolol

Fosinopril

Irbesartan

Labetalol

Levobunolol

Lisinopril

Losartan

Metipranolol

Metoprolol

Moexipril

Nadolol

Nebivolol

Olmesartan

Oxprenolol

Penbutolol

Perindopril

Pindolol

Propranolol

Quinapril

Ramipril

Sotalol

Spirapril

Telmisartan

Timolol

Trandolapril

Valsartan

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Tobacco

Relate drugs

How to use Chlorpheniramine, ibuprofen, and phenylephrine

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Follow the instructions on the medicine label if you are using this medicine without a prescription.

You may take this medicine with milk or food to avoid stomach upset.

Do not drink 3 or more alcoholic drinks while you are using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For symptoms of allergies and cold:

Adults and children 12 years of age and older—1 tablet every 4 hours a day. Do not take more than 6 tablets per day. Each tablet contains 4 milligrams (mg) chlorpheniramine, 200 mg ibuprofen, and 10 mg phenylephrine.

Children younger than 12 years of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

If your or your child's symptoms do not improve within a few days (eg, fever for more than 3 days, stuffy nose or pain for more than 7 days), or if they become worse, check with your doctor.

Using this medicine during late pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use this medicine if you have used an MAO inhibitor (MAOI), including Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 2 weeks.

This medicine may cause a serious allergic reaction, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.

This medicine may cause bleeding in your stomach or bowels. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or using certain other medicines (eg, NSAIDs, steroid, blood thinner). Call your doctor right away if you have severe stomach pain, black, tarry stools, or are vomiting blood or material that looks like coffee grounds.

This medicine may increase your risk of having a heart attack, heart failure, or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. Some signs of serious heart problems are chest pain or tightness, fast or irregular heartbeat, or unusual flushing or warmth of the skin. Check with your doctor right away if you notice any of these warning signs.

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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