Cibinqo
Generic name: Abrocitinib
Dosage form: tablets (50mg, 100mg, 200mg)
Drug class:
Selective immunosuppressants
Usage of Cibinqo
Cibinqo (abrocitinib) tablets are used to treat eczema (atopic dermatitis) that is moderate to severe in patients who have not found relief with topical medications or are not able to use them. Cibinqo is a once-a-day tablet that can be used by adults and children over 12 years of age.
Eczema may be caused by an overactive immune system leading to inflammation which causes dry, itchy skin and eczema flare-ups. Janus kinase (JAK) is an enzyme thought to play a role in skin inflammation. Cibinqo works by blocking the JAK1 activity, decreasing inflammation which helps reduce itching and improves skin condition.
Cibinqo belongs to a class of medications called JAK inhibitors (Janus kinase inhibitors).
Cibinqo received FDA-approval on January 14, 2022.
Cibinqo side effects
Get emergency medical help if you have signs of an allergic reaction to Cibinqo: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common Cibinqo side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Cibinqo
You should not use Cibinqo with other medicines that prevent blood clots during the first 3 months of treatment. You can take aspirin (up to a dose of 81 mg each day) during this time if prescribed by your doctor.
To make sure Cibinqo is safe for you, tell your doctor if you:
Tell your doctor if you've had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.
Pregnancy
It is not known if Cibinqo will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of abrocitinib on the baby.
It may be harder for you to get pregnant while you are using Cibinqo.
Breastfeeding
Ask a doctor if it is safe to breastfeed while using this medicine.
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How to use Cibinqo
Usual Cibinqo Dose for Atopic Dermatitis:
Dose: 100 mg orally once a day.
Maximum dose: 200 mg/day.
Duration of therapy: If no adequate response is achieved with 100 mg/day after 12 weeks, the dose can be increased to 200 mg/day. Discontinue if inadequate response is seen after this dosage increase.
Comments: This drug should not be used in combination with other Janus kinase (JAK) inhibitors, biologic immunomodulators, or immunosuppressants. This drug can be used with or without topical corticosteroids.
Use: Refractory moderate to severe atopic dermatitis in patients 12 years of age and older, whose condition has not been adequately controlled with other systemic drug products.
Cibinqo tablets are available as: 50mg, 100mg, 200mg.
Click the link below for more detailed dose information.
Warnings
Cibinqo may increase your risk of certain cancers, such as lymphoma, lung cancer, and skin cancer. Ask your doctor about your risk.
Tell your doctor if you've had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.
Cibinqo is not recommended for use in combination with other JAK inhibitors, biologic immunomodulators, or with other immunosuppressants.
Cibinqo may cause serious side effects. Call your doctor at once if you have:
What other drugs will affect Cibinqo
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.
Cibinqo is not recommended for use in combination with other JAK inhibitors, biologic immunomodulators, or with other immunosuppressants.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may interact with abrocitinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Popular FAQ
Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid arthritis, ulcerative colitis, and psoriatic arthritis. They work by blocking enzymes that lead to overactivity of the immune system. Continue reading
List of JAK inhibitors approved in the United States include: Cibinqo (abrocitinib) Inrebic (fedratinib) Jakafi (ruxolitinib) Litfulo (ritlecitinib) Ojjaara (momelotinib) Olumiant (baricitinib) Opzelura (ruxolitinib) Rinvoq (upadacitinib) Vonjo (pacritinib) Xeljanz (tofacitinib) Continue reading
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