Cimduo

Generic name: Lamivudine And Tenofovir
Drug class: Antiviral combinations

Usage of Cimduo

Cimduo contains a combination of lamivudine and tenofovir. Lamivudine and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body.

Cimduo is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

Cimduo is not a cure for HIV or AIDS.

Cimduo is used in adults and children who weigh at least 77 pounds.

Cimduo side effects

Get emergency medical help if you have signs of an allergic reaction to Cimduo: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

new or worsening bone pain;

muscle weakness;

pain in your arms, hands, legs, or feet;

swelling around your midsection;

kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

signs of liver or pancreas problems - loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Cimduo affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Cimduo side effects may include:

headache;

pain;

diarrhea;

rash;

depression; or

changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Cimduo

You should not use Cimduo if you are allergic to lamivudine or tenofovir.

Tell your doctor if you have ever had:

liver disease, including cirrhosis or hepatitis B or C (especially if you also use ribavirin or interferon alfa);

kidney disease (or if you are on dialysis);

a pancreas disorder; or

bone problems, including osteoporosis or a broken bone.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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How to use Cimduo

Usual Adult Dose of Cimduo for HIV Infection:

1 tablet orally once a day Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Pediatric Dose of Cimduo for HIV Infection:

At least 35 kg: 1 tablet orally once a day Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Warnings

Cimduo can cause serious side effects. Call your doctor at once if you have symptoms such as upper stomach pain, loss of appetite, dark urine, yellowing of your skin or eyes, bone pain, or muscle weakness.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

If you've ever had hepatitis B, it may become active or get worse after you stop using Cimduo. You may need frequent liver function tests for several months.

What other drugs will affect Cimduo

Cimduo can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including Advil, Motrin, and Aleve).

Tell your doctor about all your other medicines, especially other antivirals to treat HIV or hepatitis C.

Other drugs may interact with lamivudine and tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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