Ciprofloxacin (Intravenous)

Generic name: Ciprofloxacin
Drug class: Quinolones and fluoroquinolones

Usage of Ciprofloxacin (Intravenous)

Ciprofloxacin injection is used to treat bacterial infections in many different parts of the body. It is also used to treat anthrax infection after inhalational exposure. This medicine is also used to treat and prevent plague (including pneumonic and septicemic plague).

Ciprofloxacin belongs to the class of drugs known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the direct supervision of your doctor.

Ciprofloxacin (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Black, tarry stools

chest pain

chills

cough

fever

painful or difficult urination

sores, ulcers, or white spots on the lips or in the mouth

suicidal thoughts

unusual bleeding or bruising

unusual tiredness or weakness

Rare

Ankle, knee, or great toe joint pain

arm, back, or jaw pain

back or side pain

blistering, peeling, or loosening of the skin

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in walking and balance

changes in skin color, pain, tenderness, or swelling of the foot or leg

changes in urination

chest tightness or heaviness

cold, clammy, or pale skin

cough

darkening of the skin

diarrhea, watery and severe, which may also be bloody

difficulty with breathing, chewing, swallowing, or talking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

fast, slow, irregular, pounding, or racing heartbeat or pulse

flushing or redness of the skin, especially on the face and neck

headache, severe and throbbing

hoarseness

increased sensitivity of the skin to sunlight

indigestion

irregular heartbeat

itching skin

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

light-colored stools

loss of ability to use or understand speech or language

mood or mental changes

muscle spasm or jerking of the legs or arms

nausea

numbness of the hands

pain in the ankles or knees

pain or discomfort in the arms, jaw, back, or neck

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

seizures

severe constipation

severe sunburn

severe vomiting

shakiness in the legs, arms, hands, or feet

small red or purple spots on the skin

stomach cramps or pain

trouble concentrating

trouble sleeping

unsteadiness, trembling, or other problems with muscle control or coordination

vomiting

vomiting of blood

white patches in the mouth or on the tongue

yellow eyes and skin

Incidence not known

Bone pain

confusion as to time, place, or person

excessive muscle tone

increased sensitivity to pain or touch

rhythmic movement of muscles

seeing, hearing, or feeling things that are not there

swelling of the joints

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

runny nose

sneezing

Rare

Continuing ringing or buzzing or other unexplained noise in the ears

eye pain

hearing loss

loss of sense of smell

swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Ciprofloxacin (Intravenous)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ciprofloxacin injection in children. However, because of this medicine's toxicity, it should be used with caution, after other alternatives have been considered or found ineffective. Ciprofloxacin injection may be used in children to prevent anthrax infection after possible exposure, and to treat serious kidney infections.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ciprofloxacin injection in the elderly. However, elderly patients are more likely to have age-related heart or kidney problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving ciprofloxacin injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Agomelatine

Bepridil

Cisapride

Dronedarone

Eliglustat

Fezolinetant

Flibanserin

Levoketoconazole

Mesoridazine

Pimozide

Piperaquine

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Tizanidine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acalabrutinib

Acarbose

Acecainide

Adagrasib

Albiglutide

Alfentanil

Alfuzosin

Alogliptin

Alosetron

Alprazolam

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Anagrelide

Apomorphine

Aprepitant

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Artemether

Asenapine

Astemizole

Atazanavir

Avapritinib

Azimilide

Azithromycin

Bendamustine

Benzhydrocodone

Betamethasone

Bosutinib

Bretylium

Brigatinib

Budesonide

Buprenorphine

Bupropion

Buserelin

Canagliflozin

Ceritinib

Chlorpromazine

Chlorpropamide

Cholera Vaccine, Live

Cilostazol

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clothiapine

Clozapine

Codeine

Colchicine

Corticotropin

Cortisone

Cosyntropin

Crizotinib

Cyclobenzaprine

Dabrafenib

Dapagliflozin

Daridorexant

Dasatinib

Deflazacort

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexamethasone

Dexmedetomidine

Dihydrocodeine

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Dulaglutide

Duloxetine

Efavirenz

Elacestrant

Elexacaftor

Empagliflozin

Encorafenib

Entrectinib

Erlotinib

Ertugliflozin

Erythromycin

Escitalopram

Etrasimod

Exenatide

Fenfluramine

Fentanyl

Fexinidazole

Finerenone

Fingolimod

Flecainide

Fluconazole

Fludrocortisone

Fluocortolone

Fluoxetine

Formoterol

Fosaprepitant

Foscarnet

Fostemsavir

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Glimepiride

Glipizide

Glyburide

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Histrelin

Hydrocodone

Hydrocortisone

Hydroxychloroquine

Hydroxyzine

Ibrutinib

Ibutilide

Ifosfamide

Iloperidone

Imipramine

Infigratinib

Inotuzumab Ozogamicin

Insulin

Insulin Aspart, Recombinant

Insulin Bovine

Insulin Degludec

Insulin Detemir

Insulin Glulisine

Insulin Lispro, Recombinant

Ivacaftor

Ivosidenib

Ketoconazole

Lapatinib

Larotrectinib

Lefamulin

Leflunomide

Lemborexant

Lenvatinib

Leuprolide

Levofloxacin

Linagliptin

Liraglutide

Lixisenatide

Lofexidine

Lopinavir

Lumateperone

Lumefantrine

Lurasidone

Lurbinectedin

Macimorelin

Magnesium Sulfate

Mavacamten

Mefloquine

Meperidine

Metformin

Methadone

Methotrexate

Methylprednisolone

Metronidazole

Midazolam

Mifepristone

Miglitol

Mirtazapine

Mitapivat

Mobocertinib

Moricizine

Moxifloxacin

Mycophenolate Mofetil

Nafarelin

Naloxegol

Nateglinide

Nilotinib

Nitisinone

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Olaparib

Omaveloxolone

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Oxycodone

Ozanimod

Pacritinib

Paliperidone

Palovarotene

Panobinostat

Paroxetine

Pasireotide

Pazopanib

Pemigatinib

Pentazocine

Pexidartinib

Phenobarbital

Pimavanserin

Pioglitazone

Pirfenidone

Pitolisant

Pomalidomide

Ponesimod

Porfimer

Posaconazole

Pralsetinib

Pramlintide

Prednisolone

Prednisone

Primidone

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Ranolazine

Rasagiline

Relugolix

Repaglinide

Ribociclib

Rimegepant

Rosiglitazone

Saxagliptin

Selpercatinib

Selumetinib

Semaglutide

Sematilide

Sertraline

Sevoflurane

Simeprevir

Simvastatin

Siponimod

Sirolimus Protein-Bound

Sitagliptin

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sonidegib

Sorafenib

Sotalol

Sparsentan

Sufentanil

Sulpiride

Sunitinib

Tacrolimus

Tasimelteon

Tazemetostat

Tedisamil

Telavancin

Telithromycin

Teriflunomide

Tetrabenazine

Tezacaftor

Theophylline

Tolazamide

Tolbutamide

Tolvaptan

Toremifene

Tramadol

Trazodone

Triamcinolone

Triclabendazole

Trifluoperazine

Trimipramine

Triptorelin

Ubrogepant

Vandetanib

Vardenafil

Vemurafenib

Venetoclax

Venlafaxine

Vilanterol

Vinflunine

Voclosporin

Voglibose

Voriconazole

Warfarin

Zanubrutinib

Zolpidem

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Aminolevulinic Acid

Amlodipine

Chloroquine

Cyclosporine

Diclofenac

Dutasteride

Fosphenytoin

Itraconazole

Lanthanum Carbonate

Phenytoin

Probenecid

Rifapentine

Ropinirole

Ropivacaine

Sildenafil

Suvorexant

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Caffeine

Relate drugs

How to use Ciprofloxacin (Intravenous)

A nurse or other trained health professional will give you or your child this medicine. It is given through a needle placed into one of your veins. This medicine is given slowly, so the needle will have to remain in place for at least 60 minutes.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Warnings

It is very important that your doctor check your or your child's progress while receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Do not take tizanidine (Zanaflex®) while you are receiving this medicine. Tell your doctor if you or your child are also using theophylline (Theo-Dur®) or other products that contain caffeine (eg, coffee, soda, chocolate). Using these medicines together may increase risks for more serious side effects.

Ciprofloxacin may rarely cause inflammation (tendinitis) or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are receiving the medicine or after your last dose. The risk of having tendon problems may be increased if you are over 60 years of age, are using steroid medicines (eg, dexamethasone, prednisolone, prednisone, Medrol®), have severe kidney problems, have a history of tendon problems (eg, rheumatoid arthritis), or if you have ever received an organ transplant (eg, heart, kidney, or lung). Check with your doctor right away if you have sudden pain or swelling in a tendon after exercise (eg, ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are unable to bear weight or move the affected area. Refrain from exercise until your doctor says otherwise.

Tell your doctor right away if you or your child have any of the following symptoms while receiving this medicine: convulsions (seizures), feeling anxious, confused, or depressed, seeing, hearing, or feeling things that are not there, severe headache, trouble sleeping, or unusual thoughts or behaviors.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you receiving this medicine.

Check with your doctor right away if you or your child have dark urine, clay-colored stools, abdominal or stomach pain, or yellow eyes or skin. These maybe symptoms of a serious liver problem.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Ciprofloxacin injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you or your child start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

Some people who receive ciprofloxacin injection may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you or your child begin receiving this medicine:

Stay out of direct sunlight, especially between the hours of 10:00 AM and 3:00 PM, if possible.

Wear protective clothing, including a hat and sunglasses.

Apply a sun block product that has a sun protection factor (SPF) of at least 15. Some people may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.

Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Ciprofloxacin injection may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If these reactions are especially bothersome, check with your doctor.

If you are a diabetic patient taking diabetes medicine by mouth: Ciprofloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. If you or your child experience symptoms of low blood sugar, check with your doctor right away.

Symptoms of low blood sugar can include: anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty with concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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