Cobicistat and darunavir
Generic name: Cobicistat And Darunavir
Brand names: Prezcobix
Dosage form: oral tablet (150 mg-800 mg)
Drug class:
Antiviral combinations
Usage of Cobicistat and darunavir
Cobicistat and darunavir is a combination medicine given with other medicines to treat human immunodeficiency virus (HIV) in adults, the virus that can cause acquired immunodeficiency syndrome (AIDS). cobicistat and darunavir is not a cure for HIV or AIDS.
Cobicistat and darunavir is for use in people who weigh at least 88 pounds (40 kilograms).
Cobicistat and darunavir may also be used for purposes not listed in this medication guide.
Cobicistat and darunavir side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, tiredness, muscle or joint pain, blisters or skin lesions, mouth sores or ulcers, red or inflamed eyes).
Cobicistat and darunavir may cause serious side effects. Call your doctor at once if you have:
Cobicistat and darunavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
Common side effects of cobicistat and darunavir may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Cobicistat and darunavir
You should not take cobicistat and darunavir if you are allergic to cobicistat or darunavir.
Some medicines can cause unwanted or dangerous effects when used with cobicistat and darunavir. Your doctor may change your treatment plan if you also use:
Tell your doctor if you have ever had:
Cobicistat and darunavir may not work as well if you take it during pregnancy. Do not start taking this medicine if you are pregnant, and tell your doctor if you become pregnant.
If you plan to get pregnant, ask your doctor for another antiviral medicine to use during pregnancy. Use all medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
If you do not plan to get pregnant, ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. Cobicistat and darunavir can increase certain side effects when taken with hormonal birth control (pills, injections, implants, skin patches, vaginal rings).
Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Cobicistat and darunavir should not be given to children younger than 3 years of age, or to people who weigh less than 88 pounds (40 kilograms).
Relate drugs
- AccessPak for HIV PEP Basic
- AccessPak for HIV PEP Expanded with Kaletra
- AccessPak for HIV PEP Expanded with Viracept
- Atazanavir and cobicistat
- Atripla
- Cobicistat and darunavir
- Cobicistat, darunavir, emtricitabine, and tenofovir
- Cobicistat, elvitegravir, emtricitabine, and tenofovir
- Combivir
- Complera
- Abacavir and lamivudine
- Abacavir, dolutegravir, and lamivudine
- Abacavir, lamivudine, and zidovudine
- Bictegravir, emtricitabine, and tenofovir
- Bictegravir, emtricitabine, and tenofovir alafenamide
- Biktarvy
- Cabenuva
- Cabotegravir and rilpivirine
- Casirivimab and imdevimab
- Cilgavimab and tixagevimab
- Cimduo
- Darunavir and cobicistat
- Darunavir, cobicistat, emtricitabine, and tenofovir alafenamide
- Dasabuvir, ombitasvir, paritaprevir, and ritonavir
- Delstrigo
- Descovy
- Descovy Blister Pack
- Dolutegravir and lamivudine
- Dolutegravir and rilpivirine
- Doravirine, lamivudine, and tenofovir
- Dovato
- Efavirenz, emtricitabine, and tenofovir
- Efavirenz, lamivudine, and tenofovir
- Elbasvir and grazoprevir
- Elvitegravir, cobicistat, emtricitabine, and tenofovir
- Elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide
- Emtricitabine and tenofovir
- Emtricitabine and tenofovir alafenamide
- Emtricitabine, lopinavir, ritonavir, and tenofovir
- Emtricitabine, nelfinavir, and tenofovir
- Emtricitabine, rilpivirine, and tenofovir
- Emtricitabine, rilpivirine, and tenofovir alafenamide
- Epclusa
- Epzicom
- Evotaz
- Evusheld
- Genvoya
- Glecaprevir and pibrentasvir
- Harvoni
- Juluca
- Lamivudine and tenofovir
- Lamivudine and zidovudine
- Ledipasvir and sofosbuvir
- Mavyret
- Nirmatrelvir and ritonavir
- Odefsey
- Ombitasvir, paritaprevir, and ritonavir
- Ombitasvir, paritaprevir, ritonavir and dasabuvir
- Paxlovid
- Prezcobix
- Regen-Cov
- Sofosbuvir and Velpatasvir
- Sofosbuvir, velpatasvir, and voxilaprevir
- Stribild
- Symfi
- Symfi Lo
- Symtuza
- Technivie
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- Triumeq
- Triumeq PD
- Trizivir
- Truvada
- Viekira
- Viekira Pak
- Viekira XR
- Vosevi
- Zepatier
How to use Cobicistat and darunavir
Usual Adult Dose for HIV Infection:
1 tablet orally once a day with foodComments:-This drug is not recommended during pregnancy due to considerably lower exposures of darunavir and cobicistat during the second and third trimesters of pregnancy.-This drug should not be started in pregnant patients; patients who become pregnant during therapy with this drug should be switched to an alternative regimen.Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in therapy-naive and therapy-experienced patients without darunavir resistance-associated substitutions (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, L89V)
Usual Pediatric Dose for HIV Infection:
At least 40 kg: 1 tablet orally once a day with foodComments:-This drug is not recommended during pregnancy due to considerably lower exposures of darunavir and cobicistat during the second and third trimesters of pregnancy.-This drug should not be started in pregnant patients; patients who become pregnant during therapy with this drug should be switched to an alternative regimen.Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in therapy-naive and therapy-experienced patients without darunavir resistance-associated substitutions (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, L89V)
Warnings
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Call your doctor at once if you have signs of a serious side effect--upper stomach pain, vomiting, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), fever, tiredness, eye redness, muscle or joint pain, skin sores, or a skin rash with blistering.
What other drugs will affect Cobicistat and darunavir
If you also take enteric-coated didanosine (Videx EC), take it 1 hour before or 2 hours after you take cobicistat and darunavir.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect cobicistat and darunavir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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