Colchicine and probenecid

Generic name: Colchicine And Probenecid
Dosage form: oral tablet (0.5 mg-500 mg)
Drug class: Antigout agents

Usage of Colchicine and probenecid

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

Colchicine and probenecid is a combination medicine used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.

Colchicine and probenecid may also be used for purposes not listed in this medication guide.

Colchicine and probenecid side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Colchicine and probenecid may cause serious side effects. Stop using colchicine and probenecid and call your doctor at once if you have:

  • painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;
  • fever, severe muscle weakness, mood changes, seizure (convulsions);
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.

    • Common side effects of colchicine and probenecid may include:

  • mild nausea or stomach pain, loss of appetite;
  • headache;
  • dizziness;
  • hair loss; or
  • flushing (warmth, redness, or tingly feeling).

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Colchicine and probenecid

    This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

    To make sure colchicine and probenecid is safe for you, tell your doctor if you have:

  • heart disease;
  • kidney disease or a history of kidney stones;
  • liver disease;
  • a blood disease;
  • stomach problems such as an ulcer or severe intestinal disorder;
  • if you drink large amounts of alcohol; or
  • if you are receiving chemotherapy or radiation.

    • It is not known whether colchicine and probenecid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

    It is not known whether colchicine and probenecid passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

    Older adults may be more sensitive to the side effects of this medication.

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    How to use Colchicine and probenecid

    Usual Adult Dose for Gouty Arthritis:

    Initial: 1 tablet orally once a day for 1 weekMaintenance: 1 tablet orally twice a day-If symptoms of gouty arthritis are not controlled or 24-hour uric acid excretion is not above 700 mg, may increase dose in 1 tablet increments every 4 weeks as toleratedMaximum dose: 4 tablets per day Comments: -One tablet contains probenecid 500 mg-colchicine 0.5 mg.-Therapy should not be started until an acute gouty attack has subsided; if an acute attack is precipitated during therapy, this drug may be continued without changing the dose; additional colchicine or other appropriate therapy should be given to control the acute attack. -To prevent crystallization of uric acid in urine, a liberal fluid intake (2 L/day) and alkalization of the urine should be encouraged; alkalization of urine may be relaxed when serum urate levels return to normal limits and tophaceous deposits disappear.-The maintenance dose may be decreased in increments of 1 tablet every 6 months when acute attacks have been absent for 6 months or more and serum urate levels remain within normal limits; maintenance dosage should not be reduced to the point serum urate levels start to rise. Use: For the treatment of chronic gouty arthritis complicated by frequent, recurrent acute attacks of gout.

    Warnings

    This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

    What other drugs will affect Colchicine and probenecid

    Other drugs may interact with colchicine and probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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