Combigan

Generic name: Brimonidine And Timolol Ophthalmic
Drug class: Ophthalmic glaucoma agents

Usage of Combigan

Combigan contains a combination of brimonidine and timolol.

Brimonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Timolol is a beta-blocker that also reduces pressure inside the eye.

Combigan eye drops are used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).

Combigan may also be used for purposes not listed in this medication guide.

Combigan side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Combigan: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

slow or uneven heart rate;

pounding heartbeats or fluttering in your chest;

shallow breathing, feeling like you might pass out;

severe swelling, redness, or discomfort in or around your eye;

eye pain or increased watering; or

numbness or tingly feeling in your hands or feet.

Common Combigan side effects may include:

drowsiness, tired feeling;

mild itching, redness, or irritation of your eyes; or

mild stinging or burning when using the eye drops.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Combigan

You should not use Combigan eye drops if you are allergic to brimonidine or timolol, or if you have:

a history of asthma or chronic obstructive pulmonary disease (COPD); or

a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint.

To make sure Combigan is safe for you, tell your doctor if you have:

congestive heart failure, coronary artery disease, history of stroke or blood clot;

high or low blood pressure, circulation problems (such as Raynaud's syndrome);

depression;

diabetes (using brimonidine and timolol ophthalmic may make it harder for you to tell when you have low blood sugar);

a thyroid disorder;

any allergies;

myasthenia gravis; or

a history of glaucoma or increased pressure inside your eye.

FDA pregnancy category C. It is not known whether Combigan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Timolol and brimonidine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give Combigan to a child without medical advice.

Relate drugs

How to use Combigan

Use Combigan exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not use this medication while wearing contact lenses. Combigan eye drops may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Wash your hands before using the eye drops.

To apply the Combigan eye drops:

Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.

Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the Combigan eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Tell your doctor right away if you have any eye injury or infection, or if you need to have any type of surgery, especially eye surgery.

Store Combigan eye drops at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

Warnings

You should not use Combigan eye drops if you have a history of asthma or chronic obstructive pulmonary disease (COPD), or a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint.

Combigan should not be given to a child younger than 2 years old.

What other drugs will affect Combigan

Using this medicine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before using Combigan with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Combigan, especially:

digoxin, digitalis;

reserpine;

an antidepressant--amitriptyline, bupropion, clomipramine, desipramine, doxepin, duloxetine, fluoxetine, imipramine, nortriptyline, paroxetine;

an MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine;

a beta blocker--atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol, and others; or

heart or blood pressure medicine--amlodipine, diltiazem, methyldopa, nifedipine, quinidine, verapamil, and others.

This list is not complete. Other drugs may interact with Combigan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.