Combogesic

Generic name: Acetaminophen And Ibuprofen
Dosage form: tablets
Drug class: Analgesic combinations

Usage of Combogesic

Combogesic is a combination prescription medicine that contains acetaminophen and ibuprofen (a nonsteroidal anti-inflammatory drug [NSAID]).

It is used in adults for the short-term management of mild to moderate acute pain.

Each Combogesic pill contains acetaminophen 325 mg and ibuprofen 97.5 mg. The combination has been shown to work faster and relieve pain more effectively than either acetaminophen or ibuprofen alone.

Combogesic side effects

Combogesic may cause serious side effects, including:

See Important information.

  • new or worse high blood pressure
  • heart failure
  • liver problems including liver failure
  • kidney problems including kidney failure
  • low potassium level in your blood (hyperkalemia)
  • life-threatening allergic reactions
  • life-threatening skin reactions
  • low red blood cells (anemia)
  • changes in your vision

    • Other side effects include: nausea, vomiting, headache, dizziness, sleepiness, bleeding after medical procedures, swelling of the face.

    Get emergency help right away if you get any of the following symptoms:

  • shortness of breath or trouble breathing
  • slurred speech
  • chest pain
  • swelling of the face or throat
  • weakness in one part or side of your body

    • Stop treatment and call your healthcare provider right away if you get any of the following symptoms:

  • nausea
  • vomit blood
  • more tired or weaker than usual
  • there is blood in your bowel movement or it is black and sticky like tar
  • diarrhea
  • itching
  • unusual weight gain
  • your skin or eyes look yellow
  • skin rash or blisters with fever (including rash with hives, sores in your mouth or eyes, or your skin blisters and peels)
  • indigestion or stomach pain
  • swelling of the arms, legs, hands, and feet
  • flu-like symptoms

    • These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Combogesic

    You should not take Combogesic:

  • If you are allergic to acetaminophen, ibuprofen, other NSAIDs, or to any of the ingredients. See the end of this page for a complete list of ingredients.
  • If you have had an asthma attack, hives, or other allergic reactions after taking aspirin or any other NSAIDs.
  • Right before or after heart bypass surgery.

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    How to use Combogesic

    Usual Adult Dose for Pain

    Three tablets (each tablet contains acetaminophen 325 mg and ibuprofen 97.5 mg) every 6 hours as needed for pain relief, up to a maximum of 12 tablets per day.

    Comments: - Use the lowest effective dosage for shortest duration consistent with individual patient treatment goals. - Do not administer with other acetaminophen-containing products.

    Use: - short term management of mild to moderate acute pain in adults.

    Warnings

    Combogesic may cause serious side effects, including:

  • Severe liver problems. Acetaminophen, one of the active ingredients, has caused severe and life threatening acute liver failure which caused the need for a liver transplant and has caused death.
  • Taking Combogesic with other products that contain acetaminophen can lead to serious severe liver problems and death. Do not take this medicine with other acetaminophen containing products.
  • You should not take more than 3 Combogesic tablets in one dose or more than 12 tablets in one day.
  • If you take too much Combogesic or acetaminophen, call your healthcare provider or Poison Control Center at 1-800-222-1222, or go to the nearest hospital emergency room right away.
  • Increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment and may increase:
  • with increasing doses of medicines containing NSAIDs
  • with longer use of medicines containing NSAIDs Do not take this medicine right before or after a heart surgery called a “coronary artery bypass graft (CABG)." Avoid taking Combogesic after a recent heart attack unless your healthcare provider tells you to. You may have an increased risk of another heart attack.
  • Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines:
  • anytime during use
  • without warning symptoms
  • that may cause death

    • The risk of getting an ulcer or bleeding increases with:

  • past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs
  • taking medicines called "corticosteroids", "anticoagulants", "SSRIs", or "SNRIs"
  • increasing doses of NSAIDs
  • longer use of NSAIDs
  • smoking
  • drinking alcohol
  • older age
  • poor health
  • advanced liver disease
  • bleeding problems

    • Combogesic should only be taken exactly as prescribed, at the lowest dose possible for your treatment, and for the shortest time needed.

    What other drugs will affect Combogesic

    Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    Combogesic and some other medicines can interact with each other and cause serious side effects. Do not start taking any new medicine without talking to your healthcare provider first.

    Tell your doctor if you take any of the following medicines:

  • anticoagulants (e.g., warfarin)
  • antiplatelet agents (e.g., aspirin)
  • selective serotonin reuptake inhibitors (SSRIs)
  • serotonin norepinephrine reuptake inhibitors (SNRIs)
  • angiotensin converting enzyme (ACE) inhibitors
  • angiotensin receptor blockers (ARBs)
  • beta-blockers (including propranolol)
  • loop diuretics (e.g., furosemide)
  • thiazide diuretics
  • digoxin
  • lithium
  • methotrexate
  • cyclosporine
  • other NSAIDs or salicylates (e.g., diflunisal, salsalate)
  • pemetrexed

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