Conjugated estrogens (Intravenous)

Generic name: Conjugated Estrogens
Drug class: Estrogens

Usage of Conjugated estrogens (Intravenous)

Conjugated estrogens is a medicine that contains a mixture of estrogen hormones. Conjugated estrogens injection is used to treat abnormal bleeding from your uterus caused by hormonal imbalance when your doctor has found no other cause of bleeding. This medicine is to be given for short-term use only, to provide a fast and temporary increase in your estrogen levels.

This medicine is to be given only by or under the direct supervision of a doctor.

Conjugated estrogens (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach cramps, pain, or tenderness

anxiety

backache

blistering, peeling, or loosening of the skin

bloody or clay-colored stools

changes in skin color

chest pain or discomfort

chills or fever

clear or bloody discharge from the nipple

cough or sore throat

darkened urine

difficulty with speaking

dizziness, lightheadedness, or confusion

double vision

fainting

fast heartbeat

fluid-filled skin blisters

headache, severe and throbbing

heartburn or indigestion

heavy bleeding

inability to move the arms, legs, or facial muscles

irregular heartbeats

joint or muscle pain

loss of appetite

loss of bladder control

lump in the breast or under the arm

muscle cramps in the hands, arms, feet, legs, or face

muscle spasm or jerking of all extremities

nausea, vomiting, or diarrhea

numbness and tingling around the mouth, fingertips, or feet

pain or discomfort in the arms, jaw, back, or neck

pain, redness, or swelling in the arm or leg

painful or tender cysts in the breasts

painful, red lumps under the skin, mostly on the legs

rash, hives or welts

rectal bleeding

red, irritated eyes

redness or swelling of the breast

sensitivity to the sun

sore on the skin of the breast that does not heal

sores, ulcers, or white spots in the mouth or on the lips

stomach discomfort or upset

sudden loss of consciousness

sudden shortness of breath or troubled breathing

sweating

swelling of the foot or leg

tremor

unusual tiredness or weakness

vomiting of blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Brown, blotchy spots on exposed skin

decreased interest in sexual intercourse

difficulty of wearing contact lenses

hair loss in the scalp

increase or decrease in weight

increased hair growth, especially on the face

mental depression

muscle pain or stiffness

pain or swelling at the injection site

twitching, uncontrolled movements of the tongue, lips, face, arms, or legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Conjugated estrogens (Intravenous)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Premarin® injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of Premarin® injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have breast cancer, stroke, or dementia, which may require caution in patients receiving this medicine.

Breast Feeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amifampridine

Bupropion

Donepezil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Etoricoxib

Ginseng

Levothyroxine

Licorice

Tipranavir

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

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How to use Conjugated estrogens (Intravenous)

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given into a vein or into a muscle. This medicine is not for long-term use.

This medicine comes with a patient information leaflet. Read the information carefully. Ask your doctor if you have any questions.

Warnings

It is very important that your doctor check you closely to make sure this medicine is working properly and does not cause unwanted effects. Pelvic exam, breast exam, and mammogram (breast x-ray) may be needed to check for unwanted effects, unless your doctor tells you otherwise.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Using this medicine may increase your risk of endometrial cancer, breast cancer, or uterine cancer. Talk with your doctor about this risk. If you still have your uterus (womb), ask your doctor if you should also use a progestin medicine. Check with your doctor immediately if your experience abnormal vaginal bleeding.

Using this medicine may increase your risk of dementia, especially in women 65 years of age and older.

Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. This risk may continue even after you stop using the medicine. Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol in your blood, diabetes, or are overweight or smoke cigarettes. Contact your doctor immediately if you experience confusion, difficulty speaking, double vision, headaches, an inability to move arms, legs or facial muscle, or an inability to speak.

This medicine may cause serious types of allergic reactions, including anaphylaxis and angioedema. Anaphylaxis and angioedema can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat while you are using this medicine.

Pancreatitis may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to stay in bed for an extended time. This medicine may affect the results of certain medical tests.

Check with your doctor immediately if severe headache or sudden loss of vision or any other change in vision occurs while you are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

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