Corn Cockle

Generic name: Agrostemma Githago L.
Brand names: Cockle, Corn Campion, Corn Cockle, Corn Rose, Corn-pink, Crown-of-the-field, Purple Cockle

Usage of Corn Cockle

Cytotoxic effects

Animal data

The synergistic effect of agrostin and saponin is now considered the likely mechanism of cytotoxicity. Saponins are known to alter cell membrane permeability, while agrostin has been determined to be a ribosome-inactivating protein. The combined effect of these 2 constituents has been shown to inhibit proliferation of human leukemic cells and tumor cells in mouse models.Chiu 2001, Heisler 205, Koz 2010 Activity against viruses, including the HIV virus, has also been attributed to this effect.Au 2000, Stirpe 1983, Wang 2001

Clinical data

There are no clinical data regarding the use of corn cockle for its cytotoxic effect.

Other uses

Extracts of the aerial plant parts reduced cholesterol and low-density lipoprotein in hypercholesterolemic mice.Avci 2006

Corn Cockle side effects

No recent clinical studies of corn cockle provide a basis for information on adverse effects due to toxicity concerns (see Toxicology).

Before taking Corn Cockle

Avoid use. Documented embryotoxic effects.Chan 2001

How to use Corn Cockle

No recent clinical studies of corn cockle provide a basis for dosage recommendations due to toxicity concerns. Traditionally, doses 2 to 3 g of seeds have been described; higher doses are considered toxic.Duke 2002

Warnings

Poisoning has been described, including GI irritation, severe muscle pain and cramping, vertigo, respiratory depression, vomiting, diarrhea, and salivation followed by depression and coma. A disease known as githagism is believed to be due to poisoning by corn cockle seeds and affects humans, goats, cattle, and poultry, with githagi the active toxin.Stedman 2006 The oral median lethal dose for saponins in rodents ranges from 50 to 750 mg/kg.Duke 2002

What other drugs will affect Corn Cockle

None well documented.

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