Crizanlizumab

Generic name: Crizanlizumab
Brand names: Adakveo
Dosage form: intravenous solution (tmca 10 mg/mL)
Drug class: Miscellaneous uncategorized agents

Usage of Crizanlizumab

Crizanlizumab is used in people with sickle cell disease to reduce how often certain episodes (vaso-occlusive crises) occur.

Crizanlizumab is for use in adults and children at least 16 years old.

Crizanlizumab may also be used for purposes not listed in this medication guide.

Crizanlizumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur within 24 hours after you receive crizanlizumab. Call your doctor if you feel dizzy, nauseated, tired, itchy, chilled, sweaty, or have a fever, wheezing, or shortness of breath.

Common side effects of crizanlizumab may include:

stomach pain or tenderness;

nausea;

fever;

joint pain; or

back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Crizanlizumab

Tell your doctor if you are pregnant or plan to become pregnant. Having sickle cell disease during pregnancy may increase the risk of premature birth or low birth weight. The benefit of treating sickle cell disease may outweigh any risks to the baby.

Ask a doctor if it is safe to breastfeed while using crizanlizumab.

Relate drugs

How to use Crizanlizumab

Usual Adult Dose for Sickle Cell Anemia:

Initial dose: 5 mg/kg via IV infusion every 2 weeks for 2 doses, then Maintenance dose: 5 mg/kg via IV infusion every 4 weeks Comments:-This drug may be given with or without hydroxyurea. -Use patient's actual body weight for dose calculation. Use: To reduce the frequency of vasoocclusive crises in patients 16 years or older with sickle cell disease.

Usual Pediatric Dose for Sickle Cell Anemia:

16 years or older: Initial dose: 5 mg/kg via IV infusion every 2 weeks for 2 doses, then Maintenance dose: 5 mg/kg via IV infusion every 4 weeks Comments:-This drug may be given with or without hydroxyurea. -Use patient's actual body weight for dose calculation. Use: To reduce the frequency of vasoocclusive crises in patients 16 years or older with sickle cell disease.

Warnings

Some side effects may occur within 24 hours after you receive this medicine. Tell your caregiver if you feel dizzy, nauseated, tired, itchy, chilled, sweaty, or have a fever, wheezing, or shortness of breath.

What other drugs will affect Crizanlizumab

Other drugs may affect crizanlizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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