Cromolyn (EENT)
Drug class: Antineoplastic Agents
Usage of Cromolyn (EENT)
Allergic Rhinitis
Self-medication for the symptomatic prevention and treatment of seasonal or perennial allergic rhinitis. Provides symptomatic relief of rhinorrhea, nasal congestion, sneezing, and postnasal drip.
Should not use as self-medication for the treatment of sinus infection† [off-label], asthma† [off-label], or cold symptoms† [off-label].
Allergic Ocular Disorders
Symptomatic treatment of certain allergic ocular disorders (e.g., vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis).
Has been used for the treatment of giant papillary conjunctivitis† [off-label].
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How to use Cromolyn (EENT)
General
Administration
Administer intranasally or topically to the eye.
Administer at regular intervals.
Intranasal Administration
Parents or care providers must supervise use by young children. In very young children, an adult should administer nasal solution. Use care when inserting the nozzle into the nose to avoid injury.
Prior to administration, clear nasal passages by blowing the nose; administration of a topical nasal decongestant may be necessary. Inhale through the nose during administration.
For maximum therapeutic effect, initiate therapy before (e.g., ≤1–2 weeks before) and continue at regular intervals during the period of allergen exposure.
Ophthalmic Administration
Applied topically to the eye as an ophthalmic solution just inside the lower eyelid; patients should avoid applying the solution directly on the cornea.
To avoid contamination of dropper tip and solution, avoid touching the tip of the dispensing dropper or container to the eye, fingers, or any other surface.
Dosage
Available as cromolyn sodium.
Nasal pump delivers 5.2 mg of cromolyn sodium per metered spray.
One drop of cromolyn sodium ophthalmic solution contains approximately 1.6 mg of cromolyn sodium.
Pediatric Patients
Allergic Rhinitis IntranasalChildren ≥2 years of age: 1 spray (5.2 mg) in each nostril 3 or 4 times daily given at regular intervals (morning, noon, dinner, bedtime) for ≤12 weeks. When necessary, may be used up to 6 times daily.
Allergic Ocular Disorders OphthalmicChildren ≥4 years of age: 1 or 2 drops in each eye 4–6 times daily at regular intervals.
Do not exceed recommended frequency of administration.
Adults
Allergic Rhinitis Intranasal1 spray (5.2 mg) in each nostril 3 or 4 times daily (morning, noon, dinner, bedtime) for ≤12 weeks. When necessary, may be used up to 6 times daily.
Allergic Ocular Disorders Ophthalmic1 or 2 drops in each eye 4–6 times daily at regular intervals.
Warnings
Contraindications
Warnings/Precautions
Warnings
General Precautions
Ocular EffectsOphthalmic solution: Transient stinging or burning sensation may occur.
Respiratory EffectsNasal solution: Transient nasal stinging and/or sneezing may occur immediately. Discontinue drug if nasal irritation occurs.
Specific Populations
PregnancyCategory B.
LactationNot known whether cromolyn is distributed into milk. Use ophthalmic solution with caution. With nasal spray, consult a clinician prior to use.
Pediatric UseSafety and efficacy of cromolyn sodium given as the nasal solution or ophthalmic solution not established in children <2 or <4 years of age, respectively.
Geriatric UseOphthalmic solution: No differences in safety or efficacy relative to younger adults.
Common Adverse Effects
Nasal solution: Nasal burning and stinging, nasal irritation, sneezing.
Ophthalmic solution: Transient ocular stinging or burning upon instillation.
Disclaimer
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