Cubicin

Generic name: Daptomycin
Drug class: Miscellaneous antibiotics

Usage of Cubicin

Cubicin is an antibiotic that fights bacteria in the body.

Cubicin is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream.

Cubicin is used for complicated infections, including MRSA or "super bug" infections. MRSA stands for methicillin-resistant Staphylococcus aureus.

Cubicin side effects

Get emergency medical help if you have signs of an allergic reaction to Cubicin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

fever, flu symptoms, mouth and throat ulcers, rapid heart rate, shallow breathing;

pain or burning when you urinate;

numbness, tingling, or burning pain in your hands or feet;

easy bruising, unusual bleeding;

new or worsening cough, fever, trouble breathing; or

unexplained muscle pain, tenderness, or weakness.

Common Cubicin side effects may include:

chest pain, trouble breathing;

headache, dizziness;

stomach pain, vomiting;

swelling;

abnormal liver function tests;

rash, itching, sweating;

trouble sleeping;

sore throat; or

increased blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Cubicin

You should not use Cubicin if you are allergic to daptomycin.

To make sure Cubicin is safe for you, tell your doctor if you have ever had:

kidney disease; or

a nerve or muscle disorder.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using Cubicin. Ask your doctor about any risk.

Relate drugs

How to use Cubicin

Usual Adult Dose of Cubicin for Skin and Structure Infection:

4 mg/kg IV every 24 hours for 7 to 14 days Use: For the treatment of complicated skin and skin structure infections (cSSSI) due to susceptible isolates of Staphylococcus aureus (including methicillin-resistant isolates), Streptococcus pyogenes, S agalactiae, S dysgalactiae subspecies equisimilis, and Enterococcus faecalis (vancomycin-susceptible isolates only)

Usual Adult Dose of Cubicin for Bacteremia:

6 mg/kg IV every 24 hours for 2 to 6 weeks Comments: -This drug should not be used for the treatment of left-sided infective endocarditis due to S aureus; in the clinical trial, outcomes were poor. -This drug has not been studied in patients with prosthetic valve endocarditis. -Limited safety data regarding use of this drug beyond 28 days Uses: For the treatment of patients with S aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis, due to methicillin-susceptible and methicillin-resistant isolates

Usual Adult Dose for Endocarditis:

Usual Pediatric Dose for Skin and Structure Infection:

1 to less than 2 years: 10 mg/kg IV every 24 hours 2 to 6 years: 9 mg/kg IV every 24 hours 7 to 11 years: 7 mg/kg IV every 24 hours 12 to 17 years: 5 mg/kg IV every 24 hours Duration of therapy: Up to 14 days Use: For the treatment of cSSSI due to susceptible isolates of S aureus (including methicillin-resistant isolates), S pyogenes, S agalactiae, S dysgalactiae subspecies equisimilis, and E faecalis (vancomycin-susceptible isolates only)

Usual Pediatric Dose for Bacteremia:

1 to 6 years: 12 mg/kg IV every 24 hours 7 to 11 years: 9 mg/kg IV every 24 hours 12 to 17 years: 7 mg/kg IV every 24 hours Duration of therapy: Up to 42 days Use: For the treatment of S aureus bloodstream infections (bacteremia)

Warnings

To be sure Cubicin is helping your condition, your blood may need to be tested often. Your kidney function may also need to be tested. Visit your doctor regularly.

If you are using Cubicin at home, be sure you understand how to properly mix and store the medication.

Call your doctor at once if you have a new or worsening cough, fever, trouble breathing, diarrhea that is watery or bloody, muscle pain or weakness, tingly feeling, fever or flu symptoms, dark colored urine, mouth sores, pain or burning when you urinate, urinating less than usual or not at all, pale skin, or feeling light-headed.

What other drugs will affect Cubicin

Tell your doctor about all your other medicines, especially a "statin" cholesterol medicine such as:

atorvastatin (Lipitor, Caduet);

fluvastatin (Lescol);

lovastatin (Mevacor, Altoprev, Advicor);

pitavastatin (Livalo);

pravastatin (Pravachol);

rosuvastatin (Crestor); or

simvastatin (Zocor, Simcor, Vytorin);

This list is not complete. Other drugs may interact with daptomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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