D-Penamine

Generic name: Penicillamine
Drug class: Antirheumatics

Usage of D-Penamine

D-Penamine is a chelating (KEE-late-ing) agent that binds to excess copper and removes it from the blood stream. In certain conditions, excess copper can build up in the blood stream, leading to tissue damage throughout the body.

D-Penamine is used to remove excess copper in people with an inherited condition called Wilson's disease.

D-Penamine is also used to reduce urine levels of an amino acid called cystine, which can cause stones to form in the kidneys and bladder in people with an inherited condition called cystinuria.

D-Penamine is also used to treat severe rheumatoid arthritis after other medicines have been tried without success. This medicine is not approved to treat juvenile rheumatoid arthritis.

D-Penamine may also be used for purposes not listed in this medication guide.

D-Penamine side effects

Get emergency medical help if you have signs of an allergic reaction: hives, rash; swollen glands; difficult breathing; swelling of your face, lips, tongue, or throat.

D-Penamine may cause serious side effects. Call your doctor at once if you have:

new or worsening joint pain;

muscle weakness in your arms and legs;

muscle weakness in your face, drooping eyelids, double vision, trouble chewing or swallowing;

new or worsening cough, fever, trouble breathing;

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

skin rash, peeling, or watery blisters;

pain or burning when you urinate, foamy or bloody urine, lower back pain;

swelling in your hands, legs, and feet; or

low blood cell counts--fever, chills, tiredness, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects of D-Penamine may include:

decreased sense of taste;

skin changes such as wrinkling or pimples;

stomach pain, nausea, vomiting, diarrhea, loss of appetite;

numbness or tingly feeling;

ringing in your ears; or

a wound that will not heal.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking D-Penamine

You should not use D-Penamine if you are allergic to it, or if:

you are breast-feeding;

you have kidney disease (if using D-Penamine to treat rheumatoid arthritis); or

you have developed an infection or damaged blood cells after taking D-Penamine in the past.

Some medicines can cause unwanted or dangerous effects when used with D-Penamine. Your doctor may change your treatment plan if you also use:

gold injections;

medicine to treat or prevent malaria; or

cancer medicine.

Tell your doctor if you have ever had:

kidney disease;

liver disease;

an allergy to penicillin;

a stomach ulcer;

a weak immune system; or

if you are malnourished.

Follow your doctor's instructions about taking D-Penamine if you are pregnant. Do not start or stop taking D-Penamine without your doctor's advice, and tell your doctor right away if you become pregnant.

D-Penamine may cause harm to an unborn baby and should not be used to treat cystinuria or rheumatoid arthritis if you are pregnant.

D-Penamine may be used during pregnancy to prevent a relapse of Wilson's disease. Not treating this condition during pregnancy can cause harmful or fatal effects on the mother. The benefit of preventing a relapse of Wilson's disease may outweigh any risks to the baby.

You should not breast-feed while using this medicine.

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How to use D-Penamine

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take D-Penamine on an empty stomach, at least 1 hour before or 2 hours after a meal.

Drink plenty of liquids while you are taking D-Penamine.

Do not drink milk within 1 hour before or 1 hour after you take D-Penamine.

You will need frequent urine tests.

Your condition may seem to get worse for a short time when you first start taking this medicine. Do not change your doses or medication schedule without your doctor's advice. Every person taking D-Penamine should remain under the care of a doctor.

It may take up to 3 months before your rheumatoid arthritis symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

You may need to follow a special diet while using D-Penamine. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

If you do stop taking D-Penamine for any reason, do not start taking it again until you talk to your doctor.

Your doctor may want you to take a multivitamin or take extra iron or vitamin B6 while you are taking D-Penamine. Take only the amount of supplements that your doctor has prescribed.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Warnings

You should not use D-Penamine if you are breast-feeding, if you have ever had an infection or damaged blood cells caused by this medicine, or if you have kidney disease and you need this medicine to treat rheumatoid arthritis.

Every person taking D-Penamine should remain under the close supervision of a doctor.

What other drugs will affect D-Penamine

Other drugs may affect D-Penamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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