Dabigatran
Generic name: Dabigatran
Brand names: Pradaxa
Drug class:
Thrombin inhibitors
Usage of Dabigatran
Dabigatran is used to treat blood clots deep in the body (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) in adults who have received blood thinners by injection for 5 to 10 days.
Dabigatran is used to treat blood clots in children aged 3 months to less than 18 years of age who have been treated with an injectable blood thinner for at least 5 days.
Dabigatran is used in adults and children aged 3 months to less than 18 years of age to lower the risk of a blood clot coming back after receiving treatment for blood clots.
Dabigatran is also used after hip replacement surgery to prevent a blood clot deep in the body (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE).
Dabigatran is also used to lower the risk of stroke and blood clots in adults with atrial fibrillation (a heart rhythm disorder). dabigatran is used when the atrial fibrillation is not caused by a heart valve problem.
Dabigatran may also be used for purposes not listed in this medication guide.
Dabigatran side effects
Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Also seek emergency medical attention if you have symptoms of a spinal blood clot: back pain, numbness, tingling, muscle weakness in your lower body, or loss of bladder or bowel control.
Dabigatran may cause serious side effects. Call your doctor at once if you have:
Common side effects of dabigatran may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Dabigatran
You should not take dabigatran if you are allergic to it, or if you have:
Dabigatran can cause a serious blood clot if you undergo a procedure such as a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause permanent or long-term paralysis.
Dabigatran can make it easier for you to bleed, even from a minor injury. Call your doctor if you have bleeding that will not stop.
Tell your doctor if you have or have ever HAD:
It is not known if dabigatran will harm an unborn baby. Taking dabigatran during pregnancy may cause bleeding in the mother or the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while taking dabigatran.
Relate drugs
How to use Dabigatran
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Doses are based on weight in children and teenagers. Your child's dose may change if the child gains or loses weight.
Take dabigatran capsule with a full glass of water. You may take this capsule with or without food.
Take with food if dabigatran capsules upset your stomach.
Swallow the dabigatran capsule whole and do not crush, chew, break, or open it.
Give dabigatran oral pellets before a meal to make sure your child takes the full dose.
You may also mix the pellets with apple juice or soft food (apple sauce or apple juice, mashed carrots, or mashed bananas) at room temperature. Do not mix oral pellets with any other food, milk, milk products or any other liquid.
Mixed medicine should be used right away or within 30 minutes after mixing. Do not give dabigatran using a syringe or through a feeding tube.
This medicine can also make it easier for you to bleed, even from a minor injury such as a fall or a bump on the head. Tell your doctor or seek emergency medical attention if you fall or hit your head, or have any bleeding that will not stop.
Your kidney function may need to be checked often.
Your doctor will determine how long you should take dabigatran. Do not change your dose or stop taking this medication without your doctor's advice. Stopping suddenly can increase your risk of blood clots or stroke.
Tell any doctor who treats you that you are taking dabigatran. If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are taking this medication. If you need anesthesia for a medical procedure or surgery, you may need to stop taking dabigatran for a short time.
If your child does not take all of the dabigatran oral pellets, do not give another dose at that time and go back to the regular schedule.
Do not open more than one bottle of dabigatran capsules at a time. Only open a new bottle after all the capsules in the previous bottle are gone.
Store dabigatran capsule tightly closed at room temperature, away from moisture and heat. Keep the capsules in the original container or blister pack until you are ready to take the medicine. Do not put dabigatran capsules in a pill box or pill organizer.
Throw away any unused dabigatran capsules if it has been longer than 4 months since you first opened the bottle.
Store dabigatran oral pellets at room temperature, away from moisture and heat. Keep the medicine in the original silver aluminum bag and do not open until you are ready to use the medicine. Use the oral pellets within 6 months of opening the aluminum bag.
Warnings
Do not stop taking dabigatran without your doctor's advice. Stopping it suddenly can increase your risk of blood clots or stroke.
Some drugs can increase your risk of bleeding when used with dabigatran. Tell your doctor about all other medicines you use.
Call your doctor at once if you have signs of bleeding such as: headaches, joint pain or swelling, feeling very weak or dizzy, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood, vomit that looks like coffee grounds or any bleeding that will not stop.
Dabigatran can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). Tell any doctor who treats you that you are taking dabigatran.
What other drugs will affect Dabigatran
Tell your doctor about all your current medicines. Many drugs can affect dabigatran, especially:
This list is not complete and many other drugs may affect dabigatran. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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