Dacomitinib

Generic name: Dacomitinib
Brand names: Vizimpro
Dosage form: oral tablet (15 mg; 30 mg; 45 mg)

Usage of Dacomitinib

Dacomitinib is used to treat non-small cell lung cancer that has spread to other parts of the body.

Dacomitinib is given only if your tumor has a specific genetic marker (an abnormal "EGFR" gene).

Dacomitinib may also be used for purposes not listed in this medication guide.

Dacomitinib side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dacomitinib may cause serious side effects. Call your doctor at once if you have:

  • new or worsening breathing problems (chest pain, wheezing, cough, feeling short of breath);
  • fever;
  • severe or ongoing diarrhea;
  • swelling, redness, or infection under or around your fingernails or toenails; or
  • a severe skin reaction--dry skin, redness, rash, acne, itching, peeling or blistering.

    • Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

    Common side effects of dacomitinib may include:

  • diarrhea, loss of appetite;
  • weight loss;
  • rash, itching, dry skin;
  • eye redness, dryness, or itching;
  • hair loss;
  • problems with your nails;
  • mouth sores, mouth pain; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Dacomitinib

    Tell your doctor if you have ever HAD:

  • frequent diarrhea; or
  • breathing problems (other than lung cancer).

    • May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using dacomitinib and for at least 17 days after your last dose. Tell your doctor if you become pregnant.

    Do not breastfeed while using dacomitinib, and for at least 17 days after your last dose.

    How to use Dacomitinib

    Usual Adult Dose for Non-Small Cell Lung Cancer:

    45 mg orally once a day until disease progression or uNACceptable toxicityUse: For the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mUTAtions as detected by an FDA-approved test

    Warnings

    Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

    What other drugs will affect Dacomitinib

    Take your dacomitinib dose 6 hours before or 10 hours after taking any of the following:

  • an antacid; or
  • a stomach acid reducer (such as Tagamet, Pepcid, Zantac).

    • This list is not complete. Other drugs may affect dacomitinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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