Dapagliflozin and saxagliptin

Generic name: Dapagliflozin And Saxagliptin
Brand names: Qtern
Dosage form: oral tablet (10 mg-5 mg; 5 mg-5 mg)
Drug class: Antidiabetic combinations

Usage of Dapagliflozin and saxagliptin

Dapagliflozin and Saxagliptin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Dapagliflozin and saxagliptin is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

dapagliflozin and saxagliptin is not for treating type 1 diabetes or diabetic ketoacidosis.

Dapagliflozin and saxagliptin may also be used for purposes not listed in this medication guide.

Dapagliflozin and saxagliptin side effects

Get emergency medical help if you have signs of an allergic Reaction: hives, itching, flaking or peeling skin; trouble swallowing, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Stop taking this medicine and call your doctor at once if you have:

  • severe or ongoing pain in your joints;
  • serious skin reaction--itching, blisters, breakdown of the outer layer of skin;
  • ketoacidosis (too much acid in the blood)--nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;
  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • dehydration symptoms--dizziness, weakness, feeling light-headed (like you might pass out); or
  • signs of a bladder infection--pain or burning when you urinate, increased urination, blood in your urine, pain in your pelvis or back.
  • Some people taking dapagliflozin have had bladder cancer, but it is not clear if this medicine was the actual cause.

    Common side effects of dapagliflozin and saxagliptin may include:

  • urination problems;
  • abnormal blood levels of cholesterol or triglycerides; or
  • runny nose, stuffy nose, sinus pain.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Dapagliflozin and saxagliptin

    You should not use dapagliflozin and saxagliptin if you have:

  • severe kidney disease (or if you are on dialysis); or
  • a history of severe allergic or skin reaction after taking dapagliflozin or saxagliptin.
  • Tell your doctor if you have ever had:

  • kidney disease;
  • diabetic ketoacidosis;
  • liver disease;
  • bladder cancer;
  • bladder infections or other urination problems;
  • problems with your pancreas, including surgery;
  • gallstones;
  • high triglycerides (a type of fat in the blood);
  • alcoholism;
  • if you are on a low salt diet; or
  • if you are 65 or older.
  • Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

    You should not use this medicine during the second or third trimester of pregnancy.

    You should not breastfeed while using this medicine.

    Dapagliflozin and saxagliptin is not approved for use by anyone younger than 18 years old.

    Relate drugs

    How to use Dapagliflozin and saxagliptin

    Usual Adult Dose for Diabetes Type 2:

    For patients not already taking dapagliflozin: Initial dose: dapagliflozin 5 mg/saxagliptin 5 mg orally once a day in the morning For patients tolerating dapagliflozin 5 mg and saxagliptin 5 mg once a day who require additional glycemic control: dapagliflozin 10 mg/saxagliptin 5 mg orally once a day in the morning Comments:-Volume depletion should be corrected prior to initiation. -This combination drug is not indicated for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

    Warnings

    You should not use dapagliflozin and saxagliptin if you have severe kidney disease or if you are on dialysis.

    Taking dapagliflozin and saxagliptin can make you dehydrated, which could cause you to feel weak or dizzy (especially when you stand up).

    Stop taking this medicine and call your doctor at once if you have signs of a pancreatitis, such as severe pain in your upper stomach spreading to your back, with or without vomiting,

    Dapagliflozin can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

    What other drugs will affect Dapagliflozin and saxagliptin

    Dapagliflozin and saxagliptin may not work as well when you use other medicines at the SAMe time. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all medicines you start or stop using.

    Disclaimer

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    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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