DaxibotulinumtoxinA

Generic name: DaxibotulinumtoxinA (Daxxify)
Brand names: Daxxify
Dosage form: intramuscular powder for injection (lanm 100 units)
Drug class: Skeletal muscle relaxants

Usage of DaxibotulinumtoxinA

DaxibotulinumtoxinA (Daxxify) is used in adults to temporarily lessen the appearance of facial wrinkles.

DaxibotulinumtoxinA (Daxxify) is also used in adults to treat cervical dystonia (abnormal head position and neck pain).

DaxibotulinumtoxinA (Daxxify) may also be used for purposes not listed in this medication guide.

DaxibotulinumtoxinA side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

The botulinum toxin contained in daxibotulinumtoxinA (Daxxify) can spread to other body areas beyond where it was injected. This has caused serious life-threatening side effects in some people receiving botulinum toxin injections, even for cosmetic purposes.

Call your doctor at once if you have any of these side effects (up to several hours or several weeks after an injection):

hoarse voice, trouble breathing, talking, or swallowing;

vision changes, eye pain, blurred vision, drooping eyelids, severely dry or irritated eyes (your eyes may be more sensitive to light);

unusual or severe muscle weakness (especially in a body area that was not injected with the medication);

chest pain or pressure, pain spreading to your jaw or shoulder, irregular heartbeats; or

loss of bladder control.

Common side effects of daxibotulinumtoxinA may include:

cold symptoms such as stuffy nose, sneezing, sore throat;

pain, or redness where the medicine was injected;

muscle weakness;

drooping eyelids;

headache; or

loss of the ability to move the muscles in the face.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking DaxibotulinumtoxinA

You should not receive daxibotulinumtoxinA (Daxxify) if you have an infection in the area where the medicine will be injected or are allergic to botulinum toxin or to any other botulinum toxin injection, such as rimabotulinumtoxinB (MYOBLOC), OnabotulinumtoxinA (Botox, Botox Cosmetic), abobotulinumtoxinA (DYSPORT), IncobotulinumtoxinA (XEOMIN) or prabotulinumtoxinA-xvfs (JEUVEAU).

Tell your doctor if you have or ever had:

amyotrophic lateral sclerosis (ALS, or "Lou Gehrig's disease");

myasthenia gravis;

Lambert-Eaton syndrome;

a side effect after prior use of botulinum toxin;

a breathing disorder such as asthma or emphysema;

problems with swallowing;

heart problems;

bleeding problems;

facial muscle weakness (droopy eyelids, weak forehead, trouble raising your eyebrows);

dry eyes after receiving botulinum toxin in the past;

a planned surgery;

surgery on your face; or

received other botulinum toxin injection in the past 4 months.

It is not known whether daxibotulinumtoxinA (Daxxify) will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Relate drugs

How to use DaxibotulinumtoxinA

Usual Adult Dose for GlabEllar Lines:

Inject 8 units (0.1 mL) intramuscularly into each of 5 sites (two injections in each corrugator muscle and one injection in the procerus muscle) for a total dose of 40 unitsComments:-Refer to manufacturer information for specific administration instructions, including dilution, needle orientation, and injection site diagrams.-The safety and effectiveness of dosing more frequently than every 3 months have not been clinically evaluated.Use: For the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients

Usual Adult Dose for Cervical Dystonia:

Inject 125 to 250 units intramuscularly as a divided dose among affected musclesComments:-When selecting the first dose of this drug in patients who have previously been treated with another botulinum toxin, the prior dose, response to therapy, duration of effect, and adverse event history should be considered.-Dysphagia may be reduced by limiting the dosage injected into the sternocleidomastoid muscle.-Refer to manufacturer information for specific administration instructions, including dilution.Use: For the treatment of cervical dystonia in adult patients

Warnings

The botulinum toxin contained in daxibotulinumtoxinA (Daxxify) can spread to other body areas beyond where it was injected. This can cause serious life-threatening side effects.

Call your doctor at once if you have a hoarse voice, drooping eyelids, vision problems, severe muscle weakness, loss of bladder control, or trouble breathing, talking, or swallowing. Some of these effects can occur up to several weeks after a botulinum toxin injection.

What other drugs will affect DaxibotulinumtoxinA

Tell your doctor about all your other medicines, especially:

an antibiotic such as amikacin, Gentamicin, kanamycin, Neomycin, Paromomycin, streptomycin, tobramycin;

a muscle relaxer;

inhaled anesthetics;

bronchodilator asthma medication;

cold or allergy medicine (Benadryl and others);

medicine to treat overactive bladder;

medicine to treat Parkinson's disease;

medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; or

seizure medicine.

This list is not complete and many other drugs may affect daxibotulinumtoxinA (Daxxify). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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