Daybue

Generic name: Trofinetide
Dosage form: oral solution
Drug class: Miscellaneous central nervous system agents

Usage of Daybue

Daybue is a prescription medicine used to treat a rare, genetic neurological disorder called Rett syndrome.

Daybue contains trofinetide, a synthetic version of a naturally occurring molecule known as the tripeptide glycine-proline-glUTAmate (GPE). The exact way by which Daybue works to treat Rett syndrome is not known, but it is thought to reduce inflammation and support synaptic function in the central nervous system.

Daybue side effects

Daybue may cause side effects, including:

Diarrhea. Diarrhea is a common side effect and it can sometimes be severe. Diarrhea may cause you to lose too much water from your body (dehydration). Tell your healthcare provider if you have diarrhea. Your healthcare provider may ask you to increase the amount you drink or take anti-diarrheal medicine as needed.

Weight loss. Daybue can cause weight loss. Tell your healthcare provider if you notice you are losing weight at any time during treatment.

The most common side effects include diarrhea and vomiting.

These are not all the possible side effects.Tell your healthcare provider if you have any side effects that bother you or do not go away. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Daybue

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

have kidney problems.

Pregnancy

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if Daybue will harm your unborn baby.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if Daybue passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Relate drugs

How to use Daybue

Usual Adult and Pediatric Dose for Rett Syndrome:

Patient Weight Dosage Volume 9 kg to less than 12 kg 5,000 mg twice daily 25 mL twice daily 12 kg to less than 20 kg 6,000 mg twice daily 30 mL twice daily 20 kg to less than 35 kg 8,000 mg twice daily 40 mL twice daily 35 kg to less than 50 kg 10,000 mg twice daily 50 mL twice daily 50 kg or more 12,000 mg twice daily 60 mL twice daily

Daybue is supplied as a pink to red, strawberry flavored oral solution containing 200 mg per mL.

Comments: - can be given orally or via gastrostomy (G) tube; doses administered via gastrojejunal (GJ) tubes must be administered through the G-port. Use: - treatment of Rett syndrome in adults and pediatric patients 2 years of age and older.

What other drugs will affect Daybue

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking Daybue with certain medicines may affect the way other medicines work and can cause serious side effects.

Especially tell your doctor if you take laxatives. Daybue can cause diarrhea, so you should stop taking laxatives before you start treatment.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.