Defitelio
Generic name: Defibrotide
Drug class:
Miscellaneous coagulation modifiers
Usage of Defitelio
Defitelio works by increasing the breakdown of clots in the blood.
Defitelio is used to treat severe veno-occlusive disease (VOD) in adults and children who have undergone chemotherapy and a stem-cell transplant. VOD happens when blood vessels in the liver become blocked, which decreases blood flow and can lead to liver damage.
Defitelio may also be used for purposes not listed in this medication guide.
Defitelio side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin rash; difficult breathing; swelling of your face, lips, tongue, or throat.
Defitelio may cause serious side effects. Call your doctor at once if you have:
Your treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of Defitelio may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Defitelio
You should not use Defitelio if you are allergic to it, or if:
To make sure Defitelio is safe for you, tell your doctor if you have:
It is not known whether Defitelio will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether defibrotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
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How to use Defitelio
Defitelio is injected into a vein through an IV. This medicine must be given slowly, and the IV infusion can last at least 2 hours.
You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
Defitelio is usually given for at least 21 days, to a maximum of 60 days if symptoms have not fully improved.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Defitelio must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Do not mix Defitelio with other medicines in the same IV line. Follow your doctor's instructions about flushing your IV line after each injection.
Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
After mixing Defitelio with a diluent, store in the refrigerator and use within 24 hours.
Mixed medicine must be used within 4 hours if you keep it at room temperature.
Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What other drugs will affect Defitelio
Other drugs may interact with defibrotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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