Deflazacort

Generic name: Deflazacort
Brand names: Emflaza
Drug class: Glucocorticoids

Usage of Deflazacort

Deflazacort is a steroid that is used to treat Duchenne muscular dystrophy in adults and children at least 2 years old.

Deflazacort is not a cure for muscular dystrophy, but deflazacort may improve muscle strength and slow the progression of disability.

Deflazacort may also be used for purposes not listed in this medication guide.

Deflazacort side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Deflazacort may cause serious side effects. Call your doctor at once if you have:

  • fever, chills, sore throat, weakness;
  • severe or ongoing diarrhea;
  • any skin rash, no matter how mild;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • swelling in your hands, feet, or lower legs;
  • severe muscle weakness;
  • decreased adrenal gland hormones--weakness, diarrhea, nausea, menstrual changes, skin discoloration, craving salty foods, and feeling light-headed;
  • increased adrenal gland hormones--weight gain in your face and upper back, slow wound healing, skin discoloration, acne, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
  • Deflazacort can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

    Common side effects of deflazacort may include:

  • increased appetite;
  • weight gain;
  • increased growth of body hair;
  • sleep problems;
  • cold symptoms such as stuffy nose, sneezing, sore throat, cough;
  • frequent urge to urinate; or
  • changes in the shape or location of body fat (especially in your face and back).
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Deflazacort

    You should not use deflazacort if you are allergic to it.

    Deflazacort should not be given to a child younger than 2 years old. Deflazacort oral suspension (liquid) contains an ingredient that can cause serious side effects or death in very young or premature babies.

    Tell your doctor if you have ever had:

  • any type of bacterial, fungal, viral, or parasite infection;
  • heart problems, high blood pressure;
  • a stroke or blood clot;
  • fluid retention;
  • kidney disease;
  • liver disease (especially hepatitis B);
  • a stomach or intestinal disorder;
  • a colostomy or ileostomy;
  • cataracts, glaucoma, or herpes infection of the eyes;
  • diabetes;
  • a nerve-muscle disorder, such as myasthenia gravis;
  • low bone mineral density; or
  • a problem with your thyroid, pituitary gland, or adrenal gland.
  • You should be current on all vaccines. Tell your doctor if you have recently received a vaccine or if you are scheduled for a booster dose.

    Long-term use of steroids may lead to bone loss (osteoporosis), especially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis.

    Taking deflazacort during early pregnancy may increase the risk of cleft lip and palate in a newborn. Tell your doctor if you are pregnant or plan to become pregnant.

    Taking deflazacort at any time during pregnancy may affect adrenal gland hormones in the newborn baby. Tell your doctor if your baby has symptoms such as dry skin, weakness, feeding problems, or vomiting.

    It may not be safe to breastfeed while using deflazacort. Ask your doctor about any risk.

    Relate drugs

    How to use Deflazacort

    Usual Adult Dose for Muscular Dystrophy:

    Approximately 0.9 mg/kg orally once a dayComments:-If tablets are used, rounding up to the nearest possible dose is recommended.-If the oral suspension is used, rounding up to the nearest tenth of a mL is recommended.-If this drug has been administered for more than a few days, the dosage should be decreased gradually.Use: For the treatment of Duchenne muscular dystrophy (DMD)

    Usual Pediatric Dose for Muscular Dystrophy:

    2 years or older: Approximately 0.9 mg/kg orally once a dayComments:-If tablets are used, rounding up to the nearest possible dose is recommended.-If the oral suspension is used, rounding up to the nearest tenth of a mL is recommended.-If this drug has been administered for more than a few days, the dosage should be decreased gradually.Use: For the treatment of DMD

    Warnings

    Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

    What other drugs will affect Deflazacort

    Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

    When you start or stop taking deflazacort, your doctor may need to adjust the doses of any other medicines you take on a regular basis.

    Many drugs can affect deflazacort. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

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