Demerol

Generic name: Meperidine
Drug class: Opioids (narcotic analgesics)

Usage of Demerol

Demerol is an opioid pain medication. An opioid is sometimes called a narcotic.

Demerol is a strong prescription pain medicine that is used to manage the relief short-term pain, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them.

Careless use of Demerol can put you at risk of overdose and death. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death.

Demerol side effects

Get emergency medical help if you have signs of an allergic reaction to Demerol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using this medicine and call your doctor at once if you have:

slow heartbeats, weak or shallow breathing, breathing that stops during sleep;

severe drowsiness, feeling like you might pass out;

confusion, mood changes;

severe constipation;

tremors, muscle movements you cannot control, or a seizure (convulsions); or

low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common Demerol side effects may include:

dizziness, drowsiness;

headache;

nausea, vomiting; or

sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Demerol

You should not use Demerol if you are allergic to Meperidine, or if you have:

severe asthma or breathing problems; or

a blockage in your stomach or intestines.

Do not use Demerol if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, Selegiline, tranylcypromine, and others.

To make sure Demerol is safe for you, tell your doctor if you have ever had:

a head injury, brain tumor, or seizures;

breathing problems, sleep apnea;

drug or alcohol addiction, or mental illness;

a blockage in your stomach or intestines;

urination problems;

liver or kidney disease;

problems with your gallbladder, adrenal gland, or thyroid;

sickle cell anemia; or

abnormal curvature of the spine that affects breathing.

If you use Demerol while you are pregnant, your baby could become Dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Do not breastfeed while using Demerol. Meperidine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby.

Relate drugs

How to use Demerol

Usual Adult Dose for Pain:

Oral: 50 to 150 mg orally every 3 to 4 hours as needed Maximum dose: 600 mg per day Parenteral: 50 to 150 mg IM or suBCutaneously every 3 to 4 hours as needed; IM administration is preferred when repeated dose are required -May be administered IV, however, lower doses are advised and administration should be very slow, preferably using a diluted solution Patient Controlled Analgesia (PCA): -Initial dose: 10 mg with a range of 1 to 5 mg per incremental dose; Lockout interval: 6 to 10 minutes; adjust dose based on patient response For continuous IV infusion, the usual adult dose is 15 to 35 mg per hour Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Usual Pediatric Dose for Pain:

Oral: Initial dose: 1.1 to 1.8 mg/kg orally every 3 to 4 hours as needed Maximum single dose: 50 to 150 mg Maximum daily dose: 600 mg Parenteral: Initial dose: 1.1 to 1.8 mg/kg IM or subcutaneously every 3 to 4 hours as needed; IM administration is preferred when repeated doses are required Maximum single dose: 50 to 150 mg -May be administered IV, however, lower doses are advised and administration should be very slow, preferably using a diluted solution Comments: -The American Pain Society (APS) does not recommend this drug be used as an analgesic in infants, children, and those with acute vaso-occlusive crisis pain associated with sickle-cell disease. -Due to the risks of addiction, abuse, and misuse, this drug should be reserved for use in patients for whom alternative treatment options have not been tolerated or are not expected to be tolerated or have not provided adequate analgesia, or are not expected to provide adequate analgesia. -This drug should not be used for the treatment of chronic pain. Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Warnings

You should not use Demerol if you have severe asthma or breathing problems.

Do not use Demerol if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Demerol can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Using this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use Demerol with alcohol, or with other drugs that cause drowsiness or slow your breathing.

What other drugs will affect Demerol

You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

other narcotic medications - opioid pain medicine or prescription cough medicine;

a sedative like Valium - Diazepam, alprazolam, Xanax, lorazepam, Ativan, Klonopin, Versed, and others;

drugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or

drugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting.

This list is not complete. Other drugs may interact with meperidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Disclaimer

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